TRIFORC
"A pipeline for the discovery, sustainable production and commercial utilisation of known and novel high-value triterpenes with new or superior biological activities."
| Coordinatore | KOBENHAVNS UNIVERSITET
Organization address
postcode: 1017 contact info |
| Nazionalità Coordinatore | Denmark [DK] |
| Totale costo | 8˙875˙839 € |
| EC contributo | 6˙882˙055 € |
| Programma | FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology |
| Code Call | FP7-KBBE-2013-7-single-stage |
| Funding Scheme | CP-TP |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-10-01 - 2017-09-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 | KOBENHAVNS UNIVERSITET | DK | coordinator | 1˙270˙960.00 |
| 2 |
SPICER CONSULTING LIMITED
Organization address
address: EDEN LABORATORY - BROADMEAD ROAD contact info |
UK (STEWARTBY) | participant | 778˙440.00 |
| 3 |
JOHN INNES CENTRE
Organization address
address: "Norwich Research Park, Colney" contact info |
UK (NORWICH) | participant | 705˙097.00 |
| 4 |
VIB
Organization address
address: Rijvisschestraat 120 contact info |
BE (ZWIJNAARDE - GENT) | participant | 660˙817.00 |
| 5 |
STOCKTON ISRAEL LTD
Organization address
address: HAMEFALSIM 17 contact info |
IL (PETACH TIKVA) | participant | 658˙640.00 |
| 6 |
ALKION BIOPHARMA SAS
Organization address
address: RUE PIERRE FONTAINE 4 contact info |
FR (EVRY) | participant | 650˙720.00 |
| 7 |
VIVACELL BIOTECHNOLOGY ESPANA SL
Organization address
address: CALLE ASTRONOMA CECILIA PAYNE S/N PLANTA 1 - EDIFICIO CENTAURO - PARQUE CIENTIFICO TECNOLOGICO DE CORDOBA 21 contact info |
ES (CORDOBA) | participant | 590˙181.00 |
| 8 |
WEIZMANN INSTITUTE OF SCIENCE
Organization address
address: HERZL STREET 234 contact info |
IL (REHOVOT) | participant | 481˙520.00 |
| 9 |
PANEPISTIMIO THESSALIAS (UNIVERSITY OF THESSALY)
Organization address
address: ARGONAFTON & FILELLINON contact info |
EL (VOLOS) | participant | 400˙160.00 |
| 10 |
EXTRASYNTHESE SAS
Organization address
address: IMPASSE JACQUARD ZI LYON NORD contact info |
FR (GENAY) | participant | 362˙880.00 |
| 11 |
UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Organization address
address: DUOMO 6 contact info |
IT (VERCELLI) | participant | 322˙640.00 |
Mappa
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Obiettivo del progetto (Objective)
'Mankind is continually screening low-molecular-weight compounds from a plethora of synthetic and natural sources in the search for molecules with novel or superior pharmaceutical, agrochemical or other biological activities. In this regard, plants are a potentially rich source of bioactive molecules. Because of their extreme diversity and complex chemistry, however, plant metabolism is still underexplored. Consequently, the full potential of plant-derived, low-molecular weight, bioactive compounds is still largely untapped. The TriForC consortium will tackle this issue by establishing an integrative and innovative pipeline for the exploitation of plant triterpenes, one of the largest classes of plant bioactive compounds with an astonishing array of structural diversity and spectrum of biological activities. The TriForC partners each bring to the consortium the necessary tools, resources, methods and production systems required to assemble the pipeline and produce high value plant bioactives for commercialisation for use as e.g. new drugs or agrochemicals. The TriForC consortia will identify new bioactive triterpenes from natural resources by exploring biodiversity. To increase diversity and bioactivity, new-to-nature triterpenes will be derived by semi-synthesis and by an elaborate metabolic engineering platform in plant and microalgal bioreactor-based production systems. To unleash the potential of triterpenes for green biotechnology, structure-activity relationships for triterpenoids will be explored via high throughput screenings for novel chemical entities with potential agrochemical and pharmacological applications. TriForC will further develop and upscale plant-based bioreactors for sustainable commercial production and bio-refining of high-value triterpenes. The TriForC project will guarantee a sustainable and industrially exploitable supply of high value plant compounds with new or superior biological activities ready for commercialisation.'