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VIVO_MECH_COLL_MIGRA

Biomechanical analysis of in vivo directional collective migration

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

VIVO_MECH_COLL_MIGRA project word cloud

Explore the words cloud of the VIVO_MECH_COLL_MIGRA project. It provides you a very rough idea of what is the project "VIVO_MECH_COLL_MIGRA" about.

chemical era vivo model cellular molecular me beneficial countless embryonic substrate translated nothing mechanosensors performed interact nc interacts biophysics migration signalling mechanisms population independent line skills cues cells regulate tools appears host complement interaction signals environment nedd9 largely multidisciplinary managerial migratory nature neural regulating created poorly screening physiology researcher contribution mechanical sensed career accumulated mechanism collaborations biomechanics directional guidance pathology cell mutually biochemical crest questions interplay

Project "VIVO_MECH_COLL_MIGRA" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.researchgate.net/profile/Elias_Barriga
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-02-02 to 2018-02-01

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	183˙454.00

Map

Project objective

Directional cell migration is important in physiology and pathology. Molecular mechanisms regulating directional migration are largely studied; but the role of mechanical cues and their interplay with biochemical signals during directional migration is poorly understood. To address this we will use Neural Crest (NC) cells, a highly migratory embryonic cell population. Evidence about how chemical cues regulate NC migration has accumulated, but nothing is known about the biomechanics of NC migration. This proposal focuses on understanding how NC interacts with the mechanical cues from its environment during directional migration in vivo, as well as understanding the molecular nature of this interaction. Thus, our aims are: Aim 1) to study the role of mechanical cues in vivo and their interplay with chemical signals during in vivo NC migration. Aim 2) identify the molecular mechanism by which the mechanical properties of the substrate are sensed and translated as signals into the NC, and to test the role of Nedd9 as a key component of this process. (Nedd9 appears in a screening that I performed to identify potential NC mechanosensors). These studies will provide new tools and information on the role of mechanical cues during directional migration in vivo, how these cues interact with chemical guidance, how are they integrated as cellular signalling within cells? These questions are poorly studied aspects of cell migration, thus our results will be a real contribution to the state-of-the-art in cell migration. This multidisciplinary proposal is will be mutually beneficial, providing the host and me with new collaborations. A research line will be created in ERA with NC as a model to study biophysics of migration in vivo. I will complement my current skills with new knowledge in biophysics of cell migration and managerial skills; this will have a countless impact in the career that I project as an independent researcher in the cell migration field.

Publications

List of publications.
year	authors and title	journal	last update
2017	Isabel Bahm, Elias H. Barriga, Antonina Frolov, Eric Theveneau, Paul Frankel, Roberto Mayor PDGF controls contact inhibition of locomotion by regulating N-cadherin during neural crest migration published pages: 2456-2468, ISSN: 0950-1991, DOI: 10.1242/dev.147926	Development 144/13	2019-06-14
2018	Mansour Alkobtawi, Heather Ray, Elias H Barriga, Mauricio Moreno, Ryan Kerney, Anne-Helene Monsoro-Burq, Jean-Pierre Saint-Jeannet, Roberto Mayor Characterization of Pax3 and Sox10 transgenic Xenopus laevis embryos as tools to study neural crest development published pages: , ISSN: 0012-1606, DOI: 10.1016/j.ydbio.2018.02.020	Developmental Biology	2019-06-14
2018	Elias H. Barriga, Kristian Franze, Guillaume Charras, Roberto Mayor Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo published pages: 523-527, ISSN: 0028-0836, DOI: 10.1038/nature25742	Nature 554/7693	2019-06-14
2017	Elias Barriga, Kristian Franze, Guillaume Charras, Roberto Mayor How mechanics orchestrate morphogenesis: Mesodermal stiffening triggers neural crest migration in vivo published pages: S46, ISSN: 0925-4773, DOI: 10.1016/j.mod.2017.04.080	Mechanisms of Development 145	2019-06-14

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