Explore the words cloud of the Amygdala Circuits project. It provides you a very rough idea of what is the project "Amygdala Circuits" about.
The following table provides information about the project.
Coordinator |
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Organization address contact info |
Coordinator Country | Switzerland [CH] |
Total cost | 2˙497˙200 € |
EC max contribution | 2˙497˙200 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2014-ADG |
Funding Scheme | ERC-ADG |
Starting year | 2016 |
Duration (year-month-day) | from 2016-01-01 to 2020-12-31 |
Take a look of project's partnership.
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1 | FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION | CH (BASEL) | coordinator | 2˙497˙200.00 |
The project outlined here addresses the fundamental question how the brain encodes and controls behavior. While we have a reasonable understanding of the role of entire brain areas in such processes, and of mechanisms at the molecular and synaptic levels, there is a big gap in our knowledge of how behavior is controlled at the level of defined neuronal circuits.
In natural environments, chances for survival depend on learning about possible aversive and appetitive outcomes and on the appropriate behavioral responses. Most studies addressing the underlying mechanisms at the level of neuronal circuits have focused on aversive learning, such as in Pavlovian fear conditioning. Understanding how activity in defined neuronal circuits mediates appetitive learning, as well as how these circuitries are shared and interact with aversive learning circuits, is a central question in the neuroscience of learning and memory and the focus of this grant application.
Using a multidisciplinary approach in mice, combining behavioral, in vivo and in vitro electrophysiological, imaging, optogenetic and state-of-the-art viral circuit tracing techniques, we aim at dissecting the neuronal circuitry of appetitive Pavlovian conditioning with a focus on the amygdala, a key brain region important for both aversive and appetitive learning. Ultimately, elucidating these mechanisms at the level of defined neurons and circuits is fundamental not only for an understanding of memory processes in the brain in general, but also to inform a mechanistic approach to psychiatric conditions associated with amygdala dysfunction and dysregulated emotional responses including anxiety and mood disorders.
year | authors and title | journal | last update |
---|---|---|---|
2016 |
Elisabeth Vogel, Sabine Krabbe, Jan Gründemann, Jaclyn I. Wamsteeker Cusulin, Andreas Lüthi Projection-Specific Dynamic Regulation of Inhibition in Amygdala Micro-Circuits published pages: 644-651, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2016.06.036 |
Neuron 91/3 | 2019-07-04 |
2016 |
Chun Xu, Sabine Krabbe, Jan Gründemann, Paolo Botta, Jonathan P. Fadok, Fumitaka Osakada, Dieter Saur, Benjamin F. Grewe, Mark J. Schnitzer, Edward M. Callaway, Andreas Lüthi Distinct Hippocampal Pathways Mediate Dissociable Roles of Context in Memory Retrieval published pages: 961-972.e16, ISSN: 0092-8674, DOI: 10.1016/j.cell.2016.09.051 |
Cell 167/4 | 2019-07-04 |
2017 |
Jonathan P. Fadok, Sabine Krabbe, Milica Markovic, Julien Courtin, Chun Xu, Lema Massi, Paolo Botta, Kristine Bylund, Christian Müller, Aleksandar Kovacevic, Philip Tovote, Andreas Lüthi A competitive inhibitory circuit for selection of active and passive fear responses published pages: 96-100, ISSN: 0028-0836, DOI: 10.1038/nature21047 |
Nature 542/7639 | 2019-07-04 |
2018 |
Karen Lavi, Gilad A. Jacobson, Kobi Rosenblum, Andreas Lüthi Encoding of Conditioned Taste Aversion in Cortico-Amygdala Circuits published pages: 278-283, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.06.053 |
Cell Reports 24/2 | 2019-07-04 |
2017 |
Benjamin F. Grewe, Jan Gründemann, Lacey J. Kitch, Jerome A. Lecoq, Jones G. Parker, Jesse D. Marshall, Margaret C. Larkin, Pablo E. Jercog, Francois Grenier, Jin Zhong Li, Andreas Lüthi, Mark J. Schnitzer Neural ensemble dynamics underlying a long-term associative memory published pages: 670-675, ISSN: 0028-0836, DOI: 10.1038/nature21682 |
Nature 543/7647 | 2019-07-04 |
2018 |
Sabine Krabbe, Jan Gründemann, Andreas Lüthi Amygdala Inhibitory Circuits Regulate Associative Fear Conditioning published pages: 800-809, ISSN: 0006-3223, DOI: 10.1016/j.biopsych.2017.10.006 |
Biological Psychiatry 83/10 | 2019-07-04 |
2018 |
Jonathan P Fadok, Milica Markovic, Philip Tovote, Andreas Lüthi New perspectives on central amygdala function published pages: 141-147, ISSN: 0959-4388, DOI: 10.1016/j.conb.2018.02.009 |
Current Opinion in Neurobiology 49 | 2019-03-18 |
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The information about "AMYGDALA CIRCUITS" are provided by the European Opendata Portal: CORDIS opendata.