MAGNEURON SIGNED
Hijacking cell signalling pathways with magnetic nanoactuators for remote-controlled stemcell therapies of neurodegenerative disorders
Total Cost €
0EC-Contrib. €
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Explore the words cloud of the MAGNEURON project. It provides you a very rough idea of what is the project "MAGNEURON" about.
Project "MAGNEURON" data sheet
The following table provides information about the project.
| Coordinator |
INSTITUT CURIE
Organization address contact info |
| Coordinator Country | France [FR] |
| Project website | http://magneuron.eu/ |
| Total cost | 3˙473˙026 € |
| EC max contribution | 3˙473˙026 € (100%) |
| Programme |
1. H2020-EU.1.2.1. (FET Open) |
| Code Call | H2020-FETOPEN-2014-2015-RIA |
| Funding Scheme | RIA |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-01-01 to 2019-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | INSTITUT CURIE | FR (PARIS) | coordinator | 638˙750.00 |
| 2 | UNIVERSITY OF KEELE | UK (KEELE) | participant | 860˙125.00 |
| 3 | RUHR-UNIVERSITAET BOCHUM | DE (BOCHUM) | participant | 681˙875.00 |
| 4 | UNIVERSITAET OSNABRUECK | DE (OSNABRUECK) | participant | 654˙000.00 |
| 5 | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS | FR (PARIS) | participant | 488˙276.00 |
| 6 | EFFICIENT INNOVATION SAS | FR (CASTELNAU LE LEZ) | participant | 150˙000.00 |
Map
Project objective
Neurodegenerative diseases, such as Parkinson’s disease, are a major public health issue given the aging population in Europe and beyond. While curative pharmacological treatment of these diseases is not in sight, cell replacement therapies (CTs) are considered very promising, in particular with the advent of stem-cell reprogramming technologies. However, a fundamental challenge in the medical application of CTs in the brain of patients lies in the lack of control of cell behaviour at the site of transplantation, and particularly their differentiation and oriented growth. The aim of this project is to introduce a fundamentally new concept for remote control of cellular functions by means of magnetic manipulation. The technology is based on magnetic nanoparticles functionalized with proteins involved in cellular signalling cascades. These biofunctionalized MNPs (bMNPs) will be delivered into target cells, where they act as intracellular signalling platforms activatable in a spatially and temporally controlled manner by external magnetic fields. The project will focus on engineering these tools for the control of neuronal cell programming and fibre outgrowth by hijacking Wnt and neurotrophin signalling, respectively, with the ulti-mate objective of advancing cell replacement therapies for PD using dopaminergic precursor neurons. To achieve this ambitious goal, we have gathered an interdisciplinary consortium interfacing scientists having cutting-edge know-how in bMNP engineering, surface functionalization and cellular nanobiophysics with renowned experts in neuronal cell differentiation, stem-cell reprogramming and regenerative (nano-)medicine. By exploiting this complementary expertise, a novel, versatile technology for magnetic control of intracellular signalling is envis-aged, which will be a breakthrough for remote actuation of cellular functions and its successful implementation in CTs for neurodegenerative diseases and injuries within the following decade.
Deliverables
| Consolidated Data Management Plan | Open Research Data Pilot | 2020-04-16 13:47:52 |
| Identification and assessment of neuronal differentiation and axonal outgrowth | Documents, reports | 2020-04-16 13:47:35 |
| Dissemination Strategy report 2 | Documents, reports | 2020-04-16 13:49:00 |
| Systematic analysis of the cell differentiation response to signalling perturbations | Documents, reports | 2020-04-16 13:47:25 |
| Protocols for activation of neuronal differentiation through key receptor tags | Documents, reports | 2020-04-16 13:47:14 |
| Final workshop | Documents, reports | 2020-04-16 13:46:52 |
| Device for parallelized stimulation and high-throughput assay | Demonstrators, pilots, prototypes | 2020-04-16 13:47:03 |
| Final Dissemination Strategy report | Documents, reports | 2020-04-16 13:46:41 |
| Characterization of magnetic manipulation in cells | Documents, reports | 2020-04-07 20:22:13 |
| Recombinant ferritin-based MNPs | Documents, reports | 2020-04-07 20:22:13 |
| Intermediate workshop | Documents, reports | 2020-04-07 20:22:13 |
| Dispersions of silica core shell MNPs | Documents, reports | 2020-04-07 20:22:13 |
| Activation of intracellular membrane-anchored small G-proteins by cytosolic MNPs | Documents, reports | 2020-04-07 20:22:13 |
| Dispersions of stabilized MNPs | Documents, reports | 2020-04-07 20:22:13 |
| Dissemination Strategy report 1 | Documents, reports | 2020-04-07 20:22:13 |
| Data Management Plan | Documents, reports | 2020-04-07 20:22:13 |
| MAGNEURON website | Websites, patent fillings, videos etc. | 2020-04-07 20:22:13 |
| Dissemination Strategy plan | Documents, reports | 2020-04-07 20:22:13 |
| MAGNEURON brochure | Documents, reports | 2020-04-07 20:22:13 |
Take a look to the deliverables list in detail: detailed list of MAGNEURON deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Marie Kappen, Domenik Liße, Jacob Piehler Nanowerkzeuge für regeneratives Nervenwachstum. published pages: 16, ISSN: , DOI: |
Gesundheit für Mensch, Tier und Pflanze 2019 | 2020-04-07 |
| 2019 |
Manon Debayle, Elie Balloul, Fatimata Dembele, Xiangzhen Xu, Mohamed Hanafi, Francois Ribot, Cornelia Monzel, Mathieu Coppey, Alexandra Fragola, Maxime Dahan, Thomas Pons, Nicolas Lequeux Zwitterionic polymer ligands: an ideal surface coating to totally suppress protein-nanoparticle corona formation? published pages: 119357, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.119357 |
Biomaterials 219 | 2020-04-07 |
| 2018 |
Loïc Toraille, Koceila Aïzel, Élie Balloul, Chiara Vicario, Cornelia Monzel, Mathieu Coppey, Emilie Secret, Jean-Michel Siaugue, João Sampaio, Stanislas Rohart, Nicolas Vernier, Louise Bonnemay, Thierry Debuisschert, Loïc Rondin, Jean-François Roch, Maxime Dahan Optical Magnetometry of Single Biocompatible Micromagnets for Quantitative Magnetogenetic and Magnetomechanical Assays published pages: 7635-7641, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.8b03222 |
Nano Letters 18/12 | 2020-04-07 |
| 2019 |
Michael Rotherham, Tasmin Nahar, Timothy Goodman, Neil Telling, Monte Gates, Alicia El Haj Magnetic Mechanoactivation of Wnt Signaling Augments Dopaminergic Differentiation of Neuronal Cells published pages: 1900091, ISSN: 2366-7478, DOI: 10.1002/adbi.201900091 |
Advanced Biosystems | 2020-04-07 |
| 2019 |
Hendrik Schöneborn, Fabian Raudzus, Emilie Secret, Nils Otten, Aude Michel, Jérome Fresnais, Christine Ménager, Jean-Michel Siaugue, Holm Zaehres, Irmgard D. Dietzel, Rolf Heumann Novel Tools towards Magnetic Guidance of Neurite Growth: (I) Guidance of Magnetic Nanoparticles into Neurite Extensions of Induced Human Neurons and In Vitro Functionalization with RAS Regulating Proteins published pages: 32, ISSN: 2079-4983, DOI: 10.3390/jfb10030032 |
Journal of Functional Biomaterials 10/3 | 2020-04-07 |
| 2018 |
Hendrik Schöneborn, Fabian Raudzus, Mathieu Coppey, Sebastian Neumann, Rolf Heumann Perspectives of RAS and RHEB GTPase Signaling Pathways in Regenerating Brain Neurons published pages: 4052, ISSN: 1422-0067, DOI: 10.3390/ijms19124052 |
International Journal of Molecular Sciences 19/12 | 2020-04-07 |
| 2018 |
Meray Serdar, Josephine Herz, Karina Kempe, Elke Winterhager, Holger Jastrow, Rolf Heumann, Ursula Felderhoff-Müser, Ivo Bendix Protection of Oligodendrocytes Through Neuronal Overexpression of the Small GTPase Ras in Hyperoxia-Induced Neonatal Brain Injury published pages: , ISSN: 1664-2295, DOI: 10.3389/fneur.2018.00175 |
Frontiers in Neurology 9 | 2020-04-07 |
| 2016 |
Panagiotis S. Athanasopoulos, Wright Jacob, Sebastian Neumann, Miriam Kutsch, Dirk Wolters, Eng K. Tan, Zoë Bichler, Christian Herrmann and Rolf Heumann Identification of protein phosphatase 2A as an interacting protein of leucine-rich repeat kinase 2 published pages: 541-554, ISSN: 1437-4315, DOI: 10.1515/hsz-2015-0189 |
Biological Chemistry 397(6) February 19, 2016 | 2020-04-07 |
| 2016 |
Drees, C.
Raj, A. N.
Kurre, R.
Busch, K. B.
Haase, M.
Piehler, J. Engineered Upconversion Nanoparticles for Resolving Protein Interactions inside Living Cells published pages: 11668-11672, ISSN: 1433-7851, DOI: 10.1002/anie.201603028 |
Angew. Chem. Int. Ed. Engl. 55 (38) Sep 12 | 2020-04-07 |
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