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SZ_TEST SIGNED

Towards Early Molecular Diagnostics of Schizophrenia

Total Cost €

0

EC-Contrib. €

0

Partnership

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Outcomes and
results

SZ_TEST project word cloud

Explore the words cloud of the SZ_TEST project. It provides you a very rough idea of what is the project "SZ_TEST" about.

cohorts ideally overarching fourth poorly clinical human exceeds substantially treat schizophrenia onset unbiased direr expertise situation prior candidate quality disabling training worldwide hypothesis arsenal omic underlying 3 neurodevelopment manner lifestyle exposure relative chronic underscores countries detect socioeconomic vulnerabilities diagnostic total 7 regional combining possibilities critical psychiatry adult devastating regions finland patient pathogens disability cell care marker man efforts corresponding efficient compound burden epigenetics reducing subjects western status animal diagnostics national severe sweden multivariate immune population considerable disorder complementary systematic northern life biotech tools risk prevalence detection molecular throughput psychosis immunology disease test healthcare globe difficult illnesses health nature genetic screens mental averages neurodevelopmental sz limited models budget defects mechanisms choices genetics degree times network aetiology emotionally

Project "SZ_TEST" data sheet

The following table provides information about the project.

Coordinator	PROTOBIOS OU Organization address address: MAEALUSE 4 city: TALLINN postcode: 12618 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Estonia [EE]
Project website	https://sztest.eu/
Total cost	990˙000 €
EC max contribution	990˙000 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2016
Funding Scheme	MSCA-RISE
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	PROTOBIOS OU PROTOBIOS OU Organization address address: MAEALUSE 4 city: TALLINN postcode: 12618 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EE (TALLINN)	coordinator	414˙000.00
2	HELSINGIN YLIOPISTO HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINGIN YLIOPISTO)	participant	139˙500.00
3	SYSTASY BIOSCIENCE GMBH SYSTASY BIOSCIENCE GMBH Organization address address: BALANSTR. 6 city: MUNCHEN postcode: 81669 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	103˙500.00
4	OU QURETEC OU QURETEC Organization address address: ULIKOOLI 6A city: TARTU postcode: 51003 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EE (TARTU)	participant	85˙500.00
5	KING'S COLLEGE LONDON KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	76˙500.00
6	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 website: www.uni-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	58˙500.00
7	TARTU ULIKOOL TARTU ULIKOOL Organization address address: ULIKOOLI 18 city: TARTU postcode: 51005 website: www.ut.ee contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EE (TARTU)	participant	49˙500.00
8	TALLINNA TEHNIKAULIKOOL TALLINNA TEHNIKAULIKOOL Organization address address: Ehitajate tee 5 city: TALLINN postcode: 12616 website: www.ttu.ee contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EE (TALLINN)	participant	27˙000.00
9	LINKOPINGS UNIVERSITET LINKOPINGS UNIVERSITET Organization address address: CAMPUS VALLA city: LINKOPING postcode: 581 83 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LINKOPING)	participant	22˙500.00
10	SIHTASUTUS TARTU ULIKOOLI KLIINIKUM SIHTASUTUS TARTU ULIKOOLI KLIINIKUM Organization address address: PUUSEPA 1A city: TARTU postcode: 50406 website: http://www.kliinikum.ee/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EE (TARTU)	participant	9˙000.00
11	ELVESYS ELVESYS Organization address address: 1-3 BIS RUE ROBERT ET SONIA DELAUNAY city: PARIS postcode: 75011 website: www.elvesys.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	4˙500.00
12	HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ Organization address address: STENBACKINKATU 9 city: HELSINKI postcode: 29 website: www.hus.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINKI)	participant	0.00

Map

Project objective

Schizophrenia (SZ) is a severe mental disorder affecting more than 0.7% of the adult population. One of the most disabling and emotionally devastating illnesses known to man, SZ is also associated with considerable socioeconomic burden. In general, the chronic nature and the high degree of patient disability make SZ the fourth leading cause of disease burden across the globe with the management costs making up ~3% of the total healthcare budget in the Western countries. The situation is even direr in some regions, including northern Sweden and Finland, where relative prevalence of SZ exceeds two to three times corresponding national or regional averages. Poorly understood aetiology and limited diagnostic arsenal make it difficult to detect and treat SZ in a timely and efficient manner. This underscores a critical need for better understanding of the mechanisms underlying SZ and development of new diagnostic possibilities allowing its early detection, ideally prior to the onset of psychosis. The SZ_TEST will address these challenges by coordinating efforts with complementary areas of expertise in genetics, epigenetics, neurodevelopment, molecular psychiatry, clinical immunology and biotech R&D. The overarching hypothesis underlying our work is that genetic vulnerabilities, neurodevelopmental defects, exposure to pathogens, immune system status and specific lifestyle choices may compound the risk of SZ and that a systematic multivariate analysis of these factors should result in substantially improved diagnostic tools. SZ_TEST will work towards the development of molecular diagnostics tools for early detection of SZ, by using relevant cohorts of human subjects, unique animal and cell models, and combining unbiased high-throughput omic screens with knowledge-based candidate marker analyses. SZ_TEST training network is expected to have a major impact on improving the quality of life and reducing the health care costs in Europe and worldwide.

Deliverables

List of deliverables.
Promotional materials including a dedicated website	Websites, patent fillings, videos etc.	2020-03-20 18:46:13
Dissemination and communication plan	Other	2020-03-20 18:46:14

Take a look to the deliverables list in detail: detailed list of SZ_TEST deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Eli-Eelika Esvald, JÃ¼rgen Tuvikene, Alex Sirp, Sudarshan Patil, Clive R. Bramham, TÃµnis Timmusk CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons published pages: 0367-19, ISSN: 0270-6474, DOI: 10.1523/jneurosci.0367-19.2019	The Journal of Neuroscience	2020-03-20
2020	Yaroslav A. Kainov, Eugene V. Makeyev A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-14204-z	Nature Communications 11/1	2020-03-20
2017	Mari Sepp, Hanna Vihma, Kaja Nurm, Mari Urb, Stephanie Cerceo Page, Kaisa Roots, Anu Hark, Brady J. Maher, Priit Pruunsild, TÃµnis Timmusk The Intellectual Disability and Schizophrenia Associated Transcription Factor TCF4 Is Regulated by Neuronal Activity and Protein Kinase A published pages: 10516-10527, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.1151-17.2017	The Journal of Neuroscience 37/43	2020-03-20
2017	Enzo Scifo, Giulio Calza, Martin Fuhrmann, Rabah Soliymani, Marc Baumann, Maciej Lalowski Recent advances in applying mass spectrometry and systems biology to determine brain dynamics published pages: 545-559, ISSN: 1478-9450, DOI: 10.1080/14789450.2017.1335200	Expert Review of Proteomics 14/6	2020-03-20
2018	Mehroz Ehsan, Matthew Kelly, Charlotte Hooper, Arash Yavari, Julia Beglov, Mohamed Bellahcene, Kirandeep Ghataorhe, Giulia Poloni, Anuj Goel, Theodosios Kyriakou, Karin Fleischanderl, Elisabeth Ehler, Eugene Makeyev, Stephan Lange, Houman Ashrafian, Charles Redwood, Benjamin Davies, Hugh Watkins, Katja Gehmlich Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion published pages: 287-296, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2018.07.248	Journal of Molecular and Cellular Cardiology 121	2020-03-20
2017	Dan Lindholm, Laura Korhonen, Ove Eriksson, Sulev KÃµks Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease published pages: , ISSN: 2296-634X, DOI: 10.3389/fcell.2017.00048	Frontiers in Cell and Developmental Biology 5	2020-03-20
2018	Helle Sadam, Arno Pihlak, Anri Kivil, Susan Pihelgas, Mariliis Jaago, Priit Adler, Jaak Vilo, Olli Vapalahti, Toomas Neuman, Dan Lindholm, Markku Partinen, Antti Vaheri, Kaia Palm Prostaglandin D2 Receptor DP1 Antibodies Predict Vaccine-induced and Spontaneous Narcolepsy Type 1: Large-scale Study of Antibody Profiling published pages: 47-59, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2018.01.043	EBioMedicine 29	2020-03-20
2018	Karina Karis, Kattri-Liis Eskla, Maria Kaare, Karin TÃ¤ht, Jana Tuusov, Tanel Visnapuu, JÃ¼rgen Innos, Mohan Jayaram, TÃµnis Timmusk, Cynthia S. Weickert, Marika VÃ¤li, Eero Vasar, Mari-Anne Philips Altered Expression Profile of IgLON Family of Neural Cell Adhesion Molecules in the Dorsolateral Prefrontal Cortex of Schizophrenic Patients published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2018.00008	Frontiers in Molecular Neuroscience 11	2020-03-20
2018	Karen Yap, Svetlana Mukhina, Gen Zhang, Jason S. C. Tan, Hong Sheng Ong, and Eugene V. Makeyev A short tandem repeat-enriched RNA assembles a nuclear compartment to control alternative splicing and promote cell survival published pages: , ISSN: , DOI:	MolCell	2020-03-20

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