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SPERMAGE

No country for old sperm: male aging, sperm aging, and external stressors as determinants of sperm quality and fertility

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SPERMAGE project word cloud

Explore the words cloud of the SPERMAGE project. It provides you a very rough idea of what is the project "SPERMAGE" about.

age causing skills offers deteriorating animal personal biosciences phenomena model provides pivotal responsible career exeter males expertise infertility brings declining levels putative fitness benefiting aging worldwide integration stored fellowship full applicants drosophila ideal world group relevance breeding evolution health mechanisms reproductive socio costing fundamental opportunity university excellent understand deterioration match ecology delayed declines benefit unclear conserved evolutionary organs melanogaster human msc time annum thought epidemic economic poorly prominent animals quality physiology near fertility groups billion sperm disentangle independent hosken pi reached turn tourmente male fatherhood toward

Project "SPERMAGE" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF EXETER Organization address address: THE QUEEN'S DRIVE NORTHCOTE HOUSE city: EXETER postcode: EX4 4QJ website: www.ex.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://biosciences.exeter.ac.uk/staff/profile/index.php
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-06-01 to 2019-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF EXETER THE UNIVERSITY OF EXETER Organization address address: THE QUEEN'S DRIVE NORTHCOTE HOUSE city: EXETER postcode: EX4 4QJ website: www.ex.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EXETER)	coordinator	195˙454.00

Map

Project objective

Deterioration in sperm quality with age is a major cause of male infertility. This has particular socio-economic relevance for Europe where fatherhood is increasingly delayed and infertility has reached near epidemic levels, costing the EU €4 billion per annum. The mechanisms causing, and the full consequences of declining sperm quality with age remain very poorly understood. For example, it is unclear how much of the reduction in sperm quality is due to advanced male age or the time sperm are stored within males reproductive organs, and we do not understand the mechanisms responsible for deteriorating sperm quality with increasing male age. The general aim of this project is to disentangle the effects of male aging and sperm aging on sperm quality, fertility and reproductive fitness using Drosophila melanogaster as a model. We will also test putative mechanisms thought to cause age-related fertility declines and test two possible general pathways through which sperm age. This proposal is a much needed integration of evolutionary ecology and sperm physiology, benefiting from the ideal match of skills and expertise of the Applicant (Tourmente - physiology), and the PI (Hosken - evolution). Since the mechanisms and phenomena studied are conserved across animals, the research proposed has high potential to produce results relevant to fundamental and applied research in human aging and reproductive health and animal breeding. The MSC fellowship will be pivotal for Applicants development toward independent research and offers the unique opportunity to work in one of the most prominent evolutionary ecology groups worldwide. The Biosciences Department at the University of Exeter is world-leading and provides excellent opportunities for the personal career development of the Applicant, who in turn brings novel skills to Exeter that will greatly benefit this group.

Publications

List of publications.
year	authors and title	journal	last update
2019	Maximiliano Tourmente, C. Ruth Archer, David J. Hosken Complex interactions between sperm viability and female fertility published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-51672-1	Scientific Reports 9/1	2019-11-18

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The information about "SPERMAGE" are provided by the European Opendata Portal: CORDIS opendata.