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TWIST

TOF PET With Strip SiPMs

Total Cost €

EC-Contrib. €

Partnership

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TWIST project word cloud

Explore the words cloud of the TWIST project. It provides you a very rough idea of what is the project "TWIST" about.

units radiotracer forms least substantially photomultiplier molecular generating enhanced tomography possibilities fundamental detection technique strip close cellular sub plan emission successful tool tests ct kev position scans area modules occurring image radio pet background point biological diseases images body interaction investigation tical operates sensitivity powerful business creation stage positron time precise subject reactions resolution sensitive basis clearer biomarkers breakthrough scanned x5 gamma building lower commercial emitters functioning imaging multiple silicon diagnosing diagnostic alter reduce crystals chemical active dosage ssipm create medical mounted determined injection erc longer tracer laboratory scanners 511 twist detector subjects move manufacture advantage

Project "TWIST" data sheet

The following table provides information about the project.

Coordinator	EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH Organization address address: ESPLANADE DES PARTICULES 1 PARCELLE 11482 DE MEYRIN BATIMENT CADASTRAL 1046 city: GENEVA 23 postcode: 1211 website: www.cern.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-PoC
Funding Scheme	ERC-POC
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2019-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH Organization address address: ESPLANADE DES PARTICULES 1 PARCELLE 11482 DE MEYRIN BATIMENT CADASTRAL 1046 city: GENEVA 23 postcode: 1211 website: www.cern.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (GENEVA 23)	coordinator	150˙000.00

Map

Project objective

TWIST will build detector modules for PET scanners that offer high sensitivity together with precise position and time resolution. TWIST will deliver high-resolution PET images with low background using a lower dosage of radio-tracer. The breakthrough is obtained due to the successful development of the new Strip Silicon PhotoMultiplier (SSiPM) within the ERC TICAL project. PET (Positron Emission Tomography) scanners create images of the distribution of positron emitters in the body of subjects under investigation. PET scans have a fundamental advantage over other forms of medical imaging, such as CT scans; since they are sensitive to the functioning of biological processes. Biomarkers are involved in chemical reactions active in molecular pathways of interest for diagnosing diseases; the image will alter according to molecular changes occurring within the area of interest. Since the imaging technique operates at the sub-cellular and molecular level of the body, it is known as molecular imaging. Although PET imaging is a very powerful diagnostic tool, an injection of a radiotracer is required. The precise time resolution of the TWIST modules with substantially reduce the background generating clearer images. The image resolution will be further enhanced due to the determination of the 511 keV gamma interaction point (including the depth of interaction). Since the depth of interaction is well determined, longer crystals can be used and the detection modules can be mounted close to the subject being scanned. This results in higher resolution images with a significant reduction (at least x5) use of radio tracer. For all developments, it is important to move from tests in the laboratory to building a system of multiple units, because this is the stage that these new developments become useful and open up commercial possibilities. The creation of a business plan to manufacture modules on a commercial basis is integrated within this proposal.

Publications

List of publications.
year	authors and title	journal	last update
2019	K. Doroud, Z. Liu, M.C.S. Williams A new geometry of scintillating crystals with strip SiPMs: a PET detector with precise position and time determination published pages: P01016-P01016, ISSN: 1748-0221, DOI: 10.1088/1748-0221/14/01/p01016	Journal of Instrumentation 14/01	2020-02-13

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The information about "TWIST" are provided by the European Opendata Portal: CORDIS opendata.