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MyPeBS SIGNED

International Randomized Study Comparing personalized, Risk-Stratified to Standard Breast Cancer Screening In Women Aged 40-70

Total Cost €

EC-Contrib. €

Partnership

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MyPeBS project word cloud

Explore the words cloud of the MyPeBS project. It provides you a very rough idea of what is the project "MyPeBS" about.

recalls randomized levels incidence stratified ing estimation france possibly reducing potentially false models trial inferior treatments cancers strategies positives unnecessary bases demonstrated breast superior overdiagnoses followed diagnoses efficacy mammographic harms older substantial risk individual intensive coverage larger biopsies stage largely belgium 20 care ones detection uk aged age alone conduct strategy mean least validate 85000 cumulative health recommendations question clinical primarily countries israel earlier despite mortality mypebs positive women standard entry variables screening international accepted polymorphisms questioned personalized cancer diagnosis genetic final density disease reduces ratio insurances italy benefit components scientific hypothesis

Project "MyPeBS" data sheet

The following table provides information about the project.

Coordinator	UNICANCER Organization address address: 101 RUE DE TOLBIAC city: PARIS postcode: 75013 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	12˙498˙983 €
EC max contribution	12˙436˙858 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SC1-2017-Two-Stage-RTD
Funding Scheme	RIA
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2025-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNICANCER UNICANCER Organization address address: 101 RUE DE TOLBIAC city: PARIS postcode: 75013 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	2˙915˙337.00
2	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 website: www.cea.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS 15)	participant	1˙328˙125.00
3	AZIENDA UNITA SANITARIA LOCALE DI REGGIO EMILIA AZIENDA UNITA SANITARIA LOCALE DI REGGIO EMILIA Organization address address: VIA AMENDOLA 2 city: REGGIO EMILIA postcode: 42100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (REGGIO EMILIA)	participant	1˙000˙220.00
4	ASSUTA MEDICAL CENTERS LTD ASSUTA MEDICAL CENTERS LTD Organization address address: HABARZEL ST 20 RAMAT HACHAYIL city: TEL AVIV postcode: 69710 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (TEL AVIV)	participant	985˙000.00
5	FONDATION JEAN DAUSSET CENTRE D'ETUDE DU POLYMORPHISME HUMAIN FONDATION FONDATION JEAN DAUSSET CENTRE D'ETUDE DU POLYMORPHISME HUMAIN FONDATION Organization address address: RUE JULIETTE DODU 27 city: PARIS 10 postcode: 75010 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS 10)	participant	946˙875.00
6	INSTITUT JULES BORDET INSTITUT JULES BORDET Organization address address: RUE HEGER BORDET 1 city: BRUXELLES postcode: 1000 website: www.bordet.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	660˙000.00
7	AZIENDA OSPEDALIERA CITTA DELLA SALUTE E DELLA SCIENZA DI TORINO AZIENDA OSPEDALIERA CITTA DELLA SALUTE E DELLA SCIENZA DI TORINO Organization address address: CORSO BRAMANTE 88 90 city: TORINO postcode: 10126 website: www.cittadellasalute.to.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TORINO)	participant	593˙400.00
8	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	545˙431.00
9	INSTITUT GUSTAVE ROUSSY INSTITUT GUSTAVE ROUSSY Organization address address: Rue Camille Desmoulins 39 city: VILLEJUIF postcode: 94805 website: http://www.igr.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VILLEJUIF)	participant	540˙750.00
10	EONIX EONIX Organization address address: BOULEVARD INITIALIS 10 city: MONS postcode: 7000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (MONS)	participant	520˙000.00
11	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	394˙312.00
12	THE UNIVERSITY OF MANCHESTER THE UNIVERSITY OF MANCHESTER Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL website: www.manchester.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MANCHESTER)	participant	310˙622.00
13	PREDILIFE PREDILIFE Organization address address: 39 RUE C. DESMOULINS 1 BAT M. TUBIANA INSTITUT G. ROUSSY IGR CAMPUS CANCER city: VILLEJUIF postcode: 94800 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VILLEJUIF)	participant	304˙181.00
14	ISTITUTO SCIENTIFICO ROMAGNOLO PERLO STUDIO E LA CURA DEI TUMORI SRL ISTITUTO SCIENTIFICO ROMAGNOLO PERLO STUDIO E LA CURA DEI TUMORI SRL Organization address address: VIA MARONCELLI 40 city: MELDOLA postcode: 47014 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MELDOLA)	participant	250˙000.00
15	ISTITUTO PER LO STUDIO E LA PREVENZIONE E LA RETE ONCOLOGICA ISTITUTO PER LO STUDIO E LA PREVENZIONE E LA RETE ONCOLOGICA Organization address address: VIA COSIMO IL VECCHIO 2 city: FIRENZE postcode: 50139 website: www.ispo.toscana.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (FIRENZE)	participant	249˙432.00
16	UNIVERSITE PARIS 13 UNIVERSITE PARIS 13 Organization address address: AVENUE JEAN-BAPTISTE CLEMENT 99 city: VILLETANEUSE postcode: 93430 website: www.univ-paris13.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VILLETANEUSE)	participant	163˙735.00
17	THE UNIVERSITY OF NOTTINGHAM THE UNIVERSITY OF NOTTINGHAM Organization address address: University Park city: NOTTINGHAM postcode: NG7 2RD website: www.nottingham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NOTTINGHAM)	participant	159˙538.00
18	UNIVERSITE LYON 1 CLAUDE BERNARD UNIVERSITE LYON 1 CLAUDE BERNARD Organization address address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43 city: VILLEURBANNE CEDEX postcode: 69622 website: www.univ-Iyon1.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VILLEURBANNE CEDEX)	participant	158˙735.00
19	QUEEN MARY UNIVERSITY OF LONDON QUEEN MARY UNIVERSITY OF LONDON Organization address address: 327 MILE END ROAD city: LONDON postcode: E1 4NS website: http://www.qmul.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	103˙940.00
20	ASSOCIATION EUROPEENNE DES LIGUES CONTRE LE CANCER ASBL ASSOCIATION EUROPEENNE DES LIGUES CONTRE LE CANCER ASBL Organization address address: CHAUSSEE DE LOUVAIN 479 city: BRUXELLES postcode: 1030 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	86˙450.00
21	INTUITIM INTUITIM Organization address address: RUE PIERRE DUPONT 200 B1 city: EVERE postcode: 1140 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (EVERE)	participant	77˙706.00
22	COLLEGE NATIONAL DES GENERALISTES ENSEIGNANTS COLLEGE NATIONAL DES GENERALISTES ENSEIGNANTS Organization address address: 3 RUE PARMENTIER city: MONTREUIL postcode: 93100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (MONTREUIL)	participant	70˙250.00
23	INDEPENDENT CANCER PATIENTS' VOICE INDEPENDENT CANCER PATIENTS' VOICE Organization address address: 17 WOODBRIDGE STREET city: LONDON postcode: EC1R 0LL website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	25˙000.00
24	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Organization address address: FRANKLIN STREET 1111, 12 FLOOR city: OAKLAND CA postcode: 94607 website: http://www.universityofcalifornia.edu/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (OAKLAND CA)	participant	25˙000.00
25	AGENCE NATIONALE DE SANTE PUBLIQUE AGENCE NATIONALE DE SANTE PUBLIQUE Organization address address: 12 RUE DU VAL D'OSNE city: SAINT MAURICE postcode: 94415 website: www.santepubliquefrance.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (SAINT MAURICE)	participant	12˙500.00
26	FONDATION ARC POUR LA RECHERCHE SUR LE CANCER FONDATION ARC POUR LA RECHERCHE SUR LE CANCER Organization address address: RUE GUY MOQUET 9 city: VILLEJUIF postcode: 94800 website: www.fondation-arc.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VILLEJUIF)	participant	6˙250.00
27	LOUGHBOROUGH UNIVERSITY LOUGHBOROUGH UNIVERSITY Organization address address: ASHBY ROAD city: LOUGHBOROUGH postcode: LE11 3TU website: www.lboro.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LOUGHBOROUGH)	participant	4˙066.00
28	IM3D SPA IM3D SPA Organization address address: PIAZZA SOLFERINO 20 city: TORINO postcode: 10121 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TORINO)	participant	0.00

Map

Project objective

MyPeBS addresses the crucial and timely question of the future of breast cancer screening in Europe. Indeed current standard mammographic screening, with entry stratified by age alone, has recently been largely questioned. Despite a demonstrated mean 20% reduction in breast cancer-specific mortality, together with reduction of late-stage disease in women older than 50, it is associated with potential harms including false positive recalls and over-diagnosis. Individual breast cancer risk estimation, through models including clinical variables, mammographic breast density and more than 100 genetic polymorphisms, now has substantial clinical and scientific bases. Personalized screening strategies, based on individual risk levels, could potentially improve the individual benefit/harms ratio of screening (earlier cancer detection and less intensive treatments in high risk women, less false positives and over-diagnoses in low risk ones), and increase the cost-efficacy for health insurances. MyPEBS will conduct an international randomized phase III trial to validate this hypothesis. It will primarily assess the ability of an individual risk-based screening strategy to be non-inferior, and possibly superior, to the standard of care screening, in reducing the cumulative incidence of stage II breast cancers. The trial, conducted in 5 countries (France, Italy, UK, Belgium and Israel) will include 85000 European women aged 40-70, all followed for 4 years. MyPEBS will also evaluate if an individual risk-based screening strategy, compared with the standard, reduces screening-related harms (unnecessary biopsies, overdiagnoses) in low-risk women, is overall at least as cost-effective as well as more accepted by women resulting in a larger screening coverage. After analyses of all components, the final objective of MyPEBS is to deliver recommendations for the best future breast cancer screening strategy in Europe.

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