Opendata, web and dolomites

CESYDE SIGNED

Ceramide Synthases in Diabetic Beta Cell Demise

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 CESYDE project word cloud

Explore the words cloud of the CESYDE project. It provides you a very rough idea of what is the project "CESYDE" about.

nutrients    ceramide    functionally    localisation    specificity    prevent    functional    modifications    pancreatic    subcellular    dependent    six    medical    tested    impair    synthesis    systemic    tissue    insulin    blocks    determined    protein    animal    stress    mediating    proteins    downstream    messenger    translational    dysfunction    manner    genomics    inhibitors    validate    proteomics    lipid    enzymes    beta    cell    modulating    suffer    worldwide    molecules    unknown    sphingolipids    deleterious    crosslinking    death    protective    total    intracellular    indicate    400    act    novo    dynamically    proliferation    chain    human    synthase    membranes    diabetes    roles    generate    cers    lipidomics    modulators    synthases    ameliorate    patients    function    secretion    metabolism    expressed    regulated    biology    mechanisms    million    sum    pharmacological    cells    combine    data    regulatory    interacting    ceramides    mouse    building    events    post    de    turn    biosynthesis    lengths    inhibition   

Project "CESYDE" data sheet

The following table provides information about the project.

Coordinator
DEUTSCHE DIABETES FORSCHUNGSGESELLSCHAFT EV 

Organization address
address: AUF M HENNEKAMP 65
city: DUESSELDORF
postcode: 40225
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙492˙313 €
 EC max contribution 1˙492˙313 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DEUTSCHE DIABETES FORSCHUNGSGESELLSCHAFT EV DE (DUESSELDORF) coordinator 1˙492˙313.00

Map

 Project objective

Sphingolipids including ceramides are building blocks of cell membranes, but also act as regulated intracellular messenger molecules. Emerging data indicate that sphingolipids are dynamically regulated by nutrients, and in turn control systemic metabolism, for example, by modulating insulin secretion, proliferation and cell death of pancreatic beta cells. Dysfunction and death of beta cells are key events during the development of diabetes, from which more than 400 million patients suffer worldwide. While pharmacological inhibition of general ceramide biosynthesis is protective against diabetes in animal studies, side effects of total loss of ceramides prevent medical implementation. The de novo synthesis of ceramides is fully dependent on six ceramide synthase enzymes (CerS 1-6), which are expressed in a tissue specific manner, and generate ceramides with different chain lengths. Currently, the functional roles and regulatory modulators of each CerS are unknown in pancreatic beta cells. Importantly, the downstream mechanisms by which ceramides impair beta cell function and eventually cause diabetes are not defined. Here, I propose to combine genomics, proteomics and lipidomics to assess the function of ceramide synthases expressed in mouse and human beta cells. Furthermore, both the subcellular localisation and the post-translational modifications of CerS will be determined. The ceramide-interacting proteins mediating the deleterious effects of ceramides will be identified by lipid-protein crosslinking and functionally tested. Finally, in a translational approach, we will test the ability of recently generated novel specific CerS inhibitors with improved specificity to ameliorate beta cell stress, and improve insulin secretion in mouse and human beta cells. In sum, we will identify, characterize, validate and target ceramide synthases involved in beta cell biology and development of diabetes.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CESYDE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CESYDE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

CohoSing (2019)

Cohomology and Singularities

Read More  

Neuro-UTR (2019)

Mechanism and functional impact of ultra-long 3’ UTRs in the Drosophila nervous system

Read More  

PROTECHT (2020)

Providing RObust high TECHnology Tags based on linear carbon nanostructures

Read More