Opendata, web and dolomites

CESYDE SIGNED

Ceramide Synthases in Diabetic Beta Cell Demise

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 CESYDE project word cloud

Explore the words cloud of the CESYDE project. It provides you a very rough idea of what is the project "CESYDE" about.

translational    animal    roles    synthase    building    functional    chain    ceramide    proteins    protective    beta    400    protein    combine    lipidomics    expressed    generate    cell    post    nutrients    tissue    biology    metabolism    functionally    secretion    mouse    mechanisms    localisation    diabetes    lengths    crosslinking    novo    membranes    inhibition    sum    unknown    synthases    modulators    manner    messenger    pancreatic    stress    insulin    dynamically    blocks    dependent    worldwide    regulatory    six    downstream    suffer    inhibitors    enzymes    indicate    human    mediating    prevent    events    modifications    genomics    patients    molecules    proteomics    deleterious    pharmacological    sphingolipids    data    tested    biosynthesis    medical    intracellular    regulated    de    specificity    lipid    interacting    cers    impair    ameliorate    synthesis    modulating    subcellular    dysfunction    turn    determined    proliferation    cells    death    total    validate    act    function    ceramides    million    systemic   

Project "CESYDE" data sheet

The following table provides information about the project.

Coordinator
DEUTSCHE DIABETES FORSCHUNGSGESELLSCHAFT EV 

Organization address
address: AUF M HENNEKAMP 65
city: DUESSELDORF
postcode: 40225
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙492˙313 €
 EC max contribution 1˙492˙313 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DEUTSCHE DIABETES FORSCHUNGSGESELLSCHAFT EV DE (DUESSELDORF) coordinator 1˙492˙313.00

Map

 Project objective

Sphingolipids including ceramides are building blocks of cell membranes, but also act as regulated intracellular messenger molecules. Emerging data indicate that sphingolipids are dynamically regulated by nutrients, and in turn control systemic metabolism, for example, by modulating insulin secretion, proliferation and cell death of pancreatic beta cells. Dysfunction and death of beta cells are key events during the development of diabetes, from which more than 400 million patients suffer worldwide. While pharmacological inhibition of general ceramide biosynthesis is protective against diabetes in animal studies, side effects of total loss of ceramides prevent medical implementation. The de novo synthesis of ceramides is fully dependent on six ceramide synthase enzymes (CerS 1-6), which are expressed in a tissue specific manner, and generate ceramides with different chain lengths. Currently, the functional roles and regulatory modulators of each CerS are unknown in pancreatic beta cells. Importantly, the downstream mechanisms by which ceramides impair beta cell function and eventually cause diabetes are not defined. Here, I propose to combine genomics, proteomics and lipidomics to assess the function of ceramide synthases expressed in mouse and human beta cells. Furthermore, both the subcellular localisation and the post-translational modifications of CerS will be determined. The ceramide-interacting proteins mediating the deleterious effects of ceramides will be identified by lipid-protein crosslinking and functionally tested. Finally, in a translational approach, we will test the ability of recently generated novel specific CerS inhibitors with improved specificity to ameliorate beta cell stress, and improve insulin secretion in mouse and human beta cells. In sum, we will identify, characterize, validate and target ceramide synthases involved in beta cell biology and development of diabetes.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CESYDE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CESYDE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

CONT-END (2018)

Attempts to Control the End of Life in People with Dementia: Two-level Approach to Examine Controversies

Read More  

CohoSing (2019)

Cohomology and Singularities

Read More  

SECURITY FLOWS (2019)

Enacting border security in the digital age: political worlds of data forms, flows and frictions.

Read More