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Multiple Sclerosis SIGNED

Development of a Functionalised Biomaterial Scaffold to Treat Multiple Sclerosis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Multiple Sclerosis project word cloud

Explore the words cloud of the Multiple Sclerosis project. It provides you a very rough idea of what is the project "Multiple Sclerosis" about.

bioactivity    symptoms    patients    completion    establishing    slice    antibody    anti    hollow    central    international    release    network    translate    collagen    dea    modifying    plan    benefit    affairs    strategy    modify    goals    evaluation    communication    skills    efficacy    maturity    model    nervous    demyelinating    optimize    secondment    professional    collaborative    functionalized    healthcare    progress    700    diversity    modest    cultures    pathology    interventions    fabricate    motivation    immune    treatments    annual    mimics    trial    multiple    preclinical    critically    dr    complementary    disease    reimbursement    leadership    billion    effect    clinic    licensed    career    people    organotypic    27    me    group    ms    multifunctional    strategies    responsive    treatment    neurodegenerative    cerebral    discipline    sectorial    mediated    chronic    inter    device    diseases    progressive    spheres    position    cns    clinical    john    inflammatory    independence    tnfr1    total    medical    prof    intellectual    training    neuroprotective    relapse    limited    progression    academic    transferable    pandit    property    regulatory    crospon    therapeutic    ros    setting    innovative    profile    loading    biocompatibility    sclerosis   

Project "Multiple Sclerosis" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2020-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 175˙866.00

Map

 Project objective

Multiple sclerosis (MS) is a chronic inflammatory immune-mediated demyelinating disease of the central nervous system (CNS), which affects 700,000 people in Europe, with total annual healthcare costs of over €27.3 billion. Current available treatments for progressive MS have modest effects on relapse symptoms but do not modify disease progression. Critically there are currently no licensed disease-modifying treatments for progressive MS. My strategy will represent a disease modifying treatment for progressive MS. I will fabricate and optimize the loading and release profile of the an anti-TNFR1 antibody from ROS-responsive collagen spheres, I will assess the biocompatibility, bioactivity, and neuroprotective effect of the anti-TNFR1 antibody functionalized ROS-responsive collagen hollow spheres in organotypic cerebral slice cultures. I will evaluate the efficacy of the anti-TNFR1 multifunctional spheres against chronic neurodegenerative pathology in a preclinical model of progressive MS that mimics the pathology seen in progressive MS patients. Progress to completion will be reviewed by a Research and Professional Development Plan which will provide both discipline-specific and complementary technical training and generic and complementary transferable skills training (intellectual property, leadership skills, motivation skills, communication skills, regulatory affairs, clinical trial design, reimbursement strategies, medical device evaluation and regulatory affairs). I will benefit from Prof Pandit’s and Dr John O’Dea’s (Crospon Limited) (inter-sectorial secondment) international collaborative network in the field of neurodegenerative diseases. This training will facilitate me to achieve my future career goals of achieving a position of professional maturity, diversity and independence by establishing my own research group at a leading European academic institution and enable me to translate innovative therapeutic interventions to the clinic setting.

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The information about "MULTIPLE SCLEROSIS" are provided by the European Opendata Portal: CORDIS opendata.

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