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CyGenTiG SIGNED

Cypergenetic Tissue Engineering

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CyGenTiG project word cloud

Explore the words cloud of the CyGenTiG project. It provides you a very rough idea of what is the project "CyGenTiG" about.

industrial inefficient machine conferred tissues connect manual network manipulate computer correcting consuming inhibited techniques academic wealth signalling biological engineered loop sensitivity social plans skills intensive feedback implications cells template alter differentiation core vision dimensional light bottleneck optogenetics molecules introduces manipulation capitalize finished impacts precisely relieving closed toward laboratories clinical synthetic labour limitation health building combines sensitive normal optical stimulated variability engineering demonstrations serious time tissue self

Project "CyGenTiG" data sheet

The following table provides information about the project.

Coordinator	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Project website	https://cygentig.ethz.ch
Total cost	4˙696˙250 €
EC max contribution	4˙696˙250 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2018
Duration (year-month-day)	from 2018-10-01 to 2023-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	coordinator	2˙506˙250.00
2	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	1˙132˙500.00
3	HEINRICH-HEINE-UNIVERSITAET DUESSELDORF HEINRICH-HEINE-UNIVERSITAET DUESSELDORF Organization address address: UNIVERSITAETSSTRASSE 1 city: DUSSELDORF postcode: 40225 website: www.uni-duesseldorf.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DUSSELDORF)	participant	818˙750.00
4	KIRKSTALL LIMITED KIRKSTALL LIMITED Organization address address: YORK HOUSE, OUTGANG LANE, OSBALDWIC, YORK city: NORTH YORKSHIRE postcode: YO19 5UP website: www.kirkstall.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NORTH YORKSHIRE)	participant	238˙750.00
5	WAGENINGEN UNIVERSITY WAGENINGEN UNIVERSITY Organization address address: DROEVENDAALSESTEEG 4 city: WAGENINGEN postcode: 6708 PB website: http://www.wageningenur.nl/nl.htm contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (WAGENINGEN)	participant	0.00

Map

Project objective

This project addresses a serious bottleneck to the widespread availability of engineered tissues for clinical use: Currently, building of new tissues requires inefficient, manual manipulation that is time-consuming, labour-intensive and introduces high variability in the finished products. Relieving this limitation has implications for both health and wealth. The project will capitalize on the skills of its network of laboratories to build and demonstrate a technology for controlling the development of engineered tissues by optogenetics and closed-loop, self-correcting control. The core technology combines machine vision and computer modelling with optical feedback, through which the computer can alter the behaviour of precisely those cells that need to be stimulated/inhibited, for the tissue to develop toward the planned template. Optical sensitivity will be conferred on cells by synthetic biological techniques. One set of demonstrations will manipulate the growth and differentiation of these cells directly. A more advanced set will use light-sensitive production of signalling molecules by engineered cells to connect optical control to the control of normal, non-engineered cells as could be used for clinical tissue engineering, in 2- and in 3-dimensional systems. Our proposal includes plans for dissemination and academic, industrial and social impacts.

Deliverables

List of deliverables.
Construction plans for optogenetic synthetic modules	Documents, reports	2020-01-14 14:24:25
Characterization of light-regulated gene expression systems	Documents, reports	2020-01-14 14:23:48
Kick-off meeting	Documents, reports	2020-01-14 14:23:13

Take a look to the deliverables list in detail: detailed list of CyGenTiG deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	David Golonka, Patrick Fischbach, Siddhartha G. Jena, Julius R. W. Kleeberg, Lars-Oliver Essen, Jared E. Toettcher, Matias D. Zurbriggen, Andreas MÃ¶glich Deconstructing and repurposing the light-regulated interplay between Arabidopsis phytochromes and interacting factors published pages: , ISSN: 2399-3642, DOI: 10.1038/s42003-019-0687-9	Communications Biology 2/1	2020-01-30

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The information about "CYGENTIG" are provided by the European Opendata Portal: CORDIS opendata.