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MesoBrainMicr SIGNED

Novel high speed and high resolution microscopy setup for cytoarchitectonic studies of mesoscale sized human brain tissues, healthy and affected by Focal Cortical Dysplasia

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MesoBrainMicr project word cloud

Explore the words cloud of the MesoBrainMicr project. It provides you a very rough idea of what is the project "MesoBrainMicr" about.

models    massively    sized    huge    progress    personality    competitiveness    mesoscale    speed    brain    cold    hierarchy    emotions    morphology    neurobiology    view    strengthen    launch    recognition    anatomy    image    unwrapping    centimeters    optics    rounded    degenerative    machine    algorithm    perform    acquired    medical    physics    leveraging    neuroinformatics    building    focal    atom    programs    expert    atlases    setup    ranging    inverted    stimulated    pathologies    functioning    microscopy    instrument    sub    researcher    transfer    microscope    learning    contributed    cellular    tightly    cytoarchitectonic    healthy    foundation    shine    investigation    resolution    acquisition    functional    interplay    intricate    decision    cortical    resolving    regions    match    dual    organization    millimiters    hardware    data    light    neuro    consequently    dysplasia    slit    mysteries    skill    international    levels    science    inside    neurobiological    tissues    host    centimeter    human    emerge    perfect    structure    memory    confocal    sheet    fruitful    neuroanatonomy   

Project "MesoBrainMicr" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITA DEGLI STUDI DI FIRENZE 

Organization address
address: Piazza San Marco 4
city: Florence
postcode: 50121
website: http://www.unifi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Italy [IT]
 Total cost 180˙277 €
 EC max contribution 180˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) coordinator 180˙277.00

Map

 Project objective

The human brain is a massively complex information processing system with a hierarchy of different yet tightly integrated levels of organization. From such intricate interplay emerge our personality, emotions, memory and decision making capabilities, but unwrapping the mysteries of the brain functioning represents a huge challenge. Recent progress in microscopy, neurobiology and neuroinformatics has stimulated the launch of large research programs such as Human Brain Project and BRAIN. An open problem is how to investigate with both high resolution and high speed the brain structure over mesoscale (millimiters to centimeters) sized regions, which would provide unique insight on the neuroanatonomy across different functional areas. This research project will develop a novel dual-view inverted dual-slit confocal light sheet microscope, capable of resolving sub-cellular morphology over centimeter-sized tissues at beyond state of the art acquisition speed. This instrument will be used to perform a comparative cytoarchitectonic investigation of mesoscale human brain tissues, both healthy and affected by Focal Cortical Dysplasia, leveraging an advanced machine learning image analysis algorithm. Such study will greatly advance the medical and neurobiological understanding of the effects of neuro-degenerative pathologies and the obtained data will be contributed to existing human brain atlases as a foundation for brain models. The applicant’s well-rounded skill set, acquired in cold atom physics and ranging from optics to hardware control, is a perfect match for building the proposed setup and for a fruitful two-way transfer of knowledge with the host, expert in advanced neuro microscopy. This research project will strengthen the competitiveness of European science and shine new light on the human brain anatomy, consequently it will raise the applicant's international recognition, and establish him inside Europe as a leading researcher in this quickly evolving field.

 Publications

year authors and title journal last update
List of publications.
2019 Giuseppe Sancataldo, Vladislav Gavryusev, Giuseppe de Vito, Lapo Turrini, Massimiliano Locatelli, Chiara Fornetto, Natascia Tiso, Francesco Vanzi, Ludovico Silvestri, Francesco Saverio Pavone
Flexible Multi-Beam Light-Sheet Fluorescence Microscope for Live Imaging Without Striping Artifacts
published pages: , ISSN: 1662-5129, DOI: 10.3389/fnana.2019.00007 		Frontiers in Neuroanatomy 13 2019-06-03

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