Opendata, web and dolomites
DNACom SIGNED
Compartmentalized DNA Computers for In-Vitro Diagnostic Applications
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0DNACom project word cloud
Explore the words cloud of the DNACom project. It provides you a very rough idea of what is the project "DNACom" about.
decreases
drugs
grant
serum
microrna
technological
portable
multiplex
improves
sized
complexity
levels
monitoring
human
proof
mirna
circuits
care
therapeutic
classification
quantitative
compartments
qpcr
polymer
efficacy
revealed
distributed
shown
speed
vitro
inside
pcr
signature
compartmentalizing
compartmentalized
commercial
answers
bsa
point
clinical
biocircuit
dna
diseases
detected
sensing
clinicians
dnacom
magnitude
computation
interpretable
signatures
molecular
transcription
computers
strands
experimental
starting
leakiness
classify
conjugate
semipermeable
computational
rt
erc
diagnosis
reverse
diagnostics
detection
prevents
platform
micrometer
breakthrough
made
albumin
validate
ivds
data
rna
combine
of
perform
bovine
setting
changes
compartmentalization
Project "DNACom" data sheet
The following table provides information about the project.
| Coordinator |
TECHNISCHE UNIVERSITEIT EINDHOVEN
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 149˙770 € |
| EC max contribution | 149˙770 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2018-PoC |
| Funding Scheme | ERC-POC |
| Starting year | 2019 |
| Duration (year-month-day) | from 2019-04-01 to 2020-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | TECHNISCHE UNIVERSITEIT EINDHOVEN | NL (EINDHOVEN) | coordinator | 149˙770.00 |
Map
Project objective
Changes in human microRNA (miRNA) levels are associated with several important human diseases. Monitoring changes in miRNA levels would enable clinicians to perform diagnosis and evaluate therapeutic efficacy of drugs. In principle, changes in a miRNA signature could be detected by existing methods such as quantitative reverse transcription PCR (RT-qPCR). However, the experimental complexity and computational analysis of the data prevents the measurements of miRNA signatures in a clinical setting. DNA-based molecular computers combine multiplex detection of DNA and RNA strands with molecular computation and are thus able to process and classify miRNA signatures into easy interpretable answers. In my ERC starting grant BioCircuit, we have made a technological breakthrough by compartmentalizing DNA-based molecular computers inside semipermeable micrometer-sized compartments made from a Bovine serum albumin (BSA) polymer conjugate. We have shown that compartmentalization of DNA circuits improves their speed by an order of magnitude and decreases their overall leakiness. Importantly, our work has revealed that this platform is capable of distributed sensing and processing of DNA and RNA strands. In 'DNACom' we will 1) establish the technical proof of concept of compartmentalized DNA computers for in-vitro molecular diagnostics (IVDs) and 2) validate the commercial application of compartmentalized DNA circuits as low-cost, portable point-of-care devices for detection and classification of microRNA signatures.
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The information about "DNACOM" are provided by the European Opendata Portal: CORDIS opendata.
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