Explore the words cloud of the Desiccation Survival project. It provides you a very rough idea of what is the project "Desiccation Survival" about.
The following table provides information about the project.
Coordinator |
UNITED KINGDOM RESEARCH AND INNOVATION
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Total cost | 212˙933 € |
EC max contribution | 212˙933 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2018 |
Funding Scheme | MSCA-IF-EF-ST |
Starting year | 2019 |
Duration (year-month-day) | from 2019-04-01 to 2021-03-31 |
Take a look of project's partnership.
# | ||||
---|---|---|---|---|
1 | UNITED KINGDOM RESEARCH AND INNOVATION | UK (SWINDON) | coordinator | 212˙933.00 |
Desiccation is a form of stress wherein extremely dry conditions cause intracellular proteins to unfold and aggregate irreversibly, resulting in cell-death. How do cells and organisms survive desiccation is a fundamental question in biology. Cytosolic Abundant Heat Soluble (CAHS) proteins, a family of intrinsically disordered proteins (IDPs) in tardigrades (a phylum of micro-animals), have been shown to be important for their survival during long periods of dryness. Under desiccation condition, CAHS proteins undergo glass-transition and gelation to form vitrified solids that protect intracellular proteins from unfolding and aggregation. However, the features of CAHS proteins that confer protection are unknown. Here, I aim to unravel the sequence determinants of CAHS protein functions, by addressing 3 specific questions:
Aim 1: What are the sequence features that promote glass-transition and gelation in CAHS proteins? Aim 2: Can we discover new sequences that can rescue cells from desiccation? Aim 3: What is the sequence-to-function paradigm underlying IDP-mediated desiccation survival?
I will (i) perform computational analysis of existing CAHS proteins to extract their sequence features to design a library for adequate sampling of the sequence space; (ii) screen the library with a high-throughput survival-based assay and validate the hits both in vitro and in vivo; (iii) analyse the results with machine learning algorithms to generate characteristic sequence features underlying protective glass-transition. The learned features will be tested by rationally designing and screening a new sequence library for desiccation survival. This project will provide fundamental sequence-level understanding of how IDPs promote stress response, specifically via glass-transition during desiccation. Moreover, the materials and pipeline generated and the findings of this study will aid in engineering functional biomaterials.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DESICCATION SURVIVAL" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "DESICCATION SURVIVAL" are provided by the European Opendata Portal: CORDIS opendata.
The effect of future global climate and land-use change on greenhouse gas fluxes and microbial processes in salt marshes
Read MoreThe Role of the Metabolism in Mosquito Immunity against Dengue virus in Aedes aegypti
Read MoreThe Comedy of Political Philosophy. Democratic Citizenship, Political Judgment, and Ideals in Political Practice.
Read More