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Trojan SIGNED

Redefining Tsetse symbiont bacteria: A Trojan horse against Trypanosome transmission

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Trojan project word cloud

Explore the words cloud of the Trojan project. It provides you a very rough idea of what is the project "Trojan" about.

identification    conceptual    vivo    stability    animals    continent    time    sustainable    interaction    infected    heterologous    idea    expression    france    therapeutic    innovative    parasitology    methodology    microbiology    eliminate    peptides    transmission    advantage    drug    fusion    nagana    entomology    antimicrobial    health    domesticated    vector    endosymbionts    overexpressed    trypanosoma    blocking    sp    expertise    evaluation    agriculture    worst    sickness    insecticidal    causes    netherlands    reduce    interference    university    methodological    sodalis    flies    groups    claim    humans    inherency    disease    solid    fluorescent    french    responsible    characterization    biology    promoters    historic    complementary    trypanosome    fly    symbionts    parasite    african    kill    competence    molecular    groningen    fighting    scourge    poverty    drastically    sleeping    secretion    avoids    trypanosomiasis    skills    active    national    tsetse    assays    progeny    rna    proteins    paratransgenesis   

Project "Trojan" data sheet

The following table provides information about the project.

Coordinator
RIJKSUNIVERSITEIT GRONINGEN 

Organization address
address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP
website: www.rug.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) coordinator 187˙572.00

Map

 Project objective

African trypanosomiasis has been a historic scourge on the African continent and one of the major causes of poverty. It is responsible for sleeping sickness in humans and it avoids the development of agriculture based on domesticated animals where it causes Nagana. It is a neglected disease with the worst drug control according to WHO. In this project, I propose a conceptual change in the therapeutic approach against Trypanosoma sp., being the goal of the proposal to eliminate the parasite in its vector, the tsetse fly, thus fighting both, sleeping sickness and Nagana. Taking advantage of the current methodological advances, the claim of this innovative proposal is the design of a new expression system to reduce or eliminate the vector competence, using for it one of the endosymbionts of the fly, Sodalis sp. The development of this idea involves a work of entomology, microbiology, parasitology and molecular biology. For this study, 2 research groups with solid and complementary expertise and skills are required: The French National Research Institute for Sustainable Development (France) and the University of Groningen (The Netherlands). The methodology implemented in this project will be: (i) characterization of proteins secretion pathways in Sodalis for heterologous expression of peptides, (ii) identification of promoters overexpressed in Sodalis upon interaction with Trypanosoma, and their characterization by fusion to fluorescent proteins, iii) paratransgenesis assays in flies and evaluation of the in vivo activity in infected and non-infected flies, stability across time and inherency to progeny, iv) analysis of the vector competence, using the new expression system by the production of antimicrobial peptides active against Trypanosoma, production of insecticidal peptides to kill the flies infected and RNA interference with the fly/symbionts. Blocking parasite transmission, we will contribute to drastically reduce the impact of trypanosome on African health.

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The information about "TROJAN" are provided by the European Opendata Portal: CORDIS opendata.

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