Opendata, web and dolomites
VacTrack SIGNED
Dissecting the protection mechanism of new generation vaccines by synchronizing systems biology with in vivo imaging
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0VacTrack project word cloud
Explore the words cloud of the VacTrack project. It provides you a very rough idea of what is the project "VacTrack" about.
advancing
transform
vesicles
save
combining
exposure
blue
potentially
vaccine
route
dissect
spatio
health
resolution
print
protection
innovatively
particle
blood
designed
validated
despite
correlates
vaccines
public
pneumococcal
vactrack
devise
holds
direction
triggered
biology
assisted
lives
protective
infection
mechanism
besides
affordable
outer
formulations
utilizing
successful
membrane
host
human
omvs
ex
antigens
transcriptome
models
diseases
burden
safety
vaccination
murine
imaging
inside
model
mouse
stimulation
comprehension
scarce
generate
grafted
temporal
global
acquire
improvement
vivo
expression
insights
immunological
efficacy
infectious
gene
Project "VacTrack" data sheet
The following table provides information about the project.
| Coordinator |
STICHTING KATHOLIEKE UNIVERSITEIT
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 281˙358 € |
| EC max contribution | 281˙358 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2019 |
| Funding Scheme | MSCA-IF-EF-CAR |
| Starting year | 2021 |
| Duration (year-month-day) | from 2021-03-01 to 2024-02-29 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | STICHTING KATHOLIEKE UNIVERSITEIT | NL (NIJMEGEN) | coordinator | 281˙358.00 |
Map
Project objective
Despite successful reduction of the burden of many infectious diseases by vaccination and the strong improvement of vaccine safety, there is a strong need to improve existing vaccines and to develop new affordable vaccines with greater efficacy. Particle-based vaccines are one of the recent advances, with potentially a promising impact on global public health. Besides being investigated for their protective potential, the knowledge about their mechanism of protection is still scarce. VacTrack is designed to investigate this by innovatively combining state of the art in vivo imaging with global transcriptome analyses. I aim to dissect the route vaccines acquire inside the host along with the spatio-temporal changes in gene expression following vaccine exposure to the host, by utilizing pneumococcal antigens grafted to outer membrane vesicles (OMVs) as model formulations in imaging-assisted in vivo mouse vaccination and challenge infection models. VacTrack is expected to generate insights about novel pathways triggered in host following vaccination which will be further validated by an ex vivo approach via stimulation of murine and human whole blood. By exploiting systems biology, high resolution in vivo imaging and immunological approaches VacTrack will provide a blue print for the approach to study mechanism of protection of vaccines in general. Comprehension of correlates of protection by combining in vivo and ex vivo analyses will 1) help devise new pneumococcal vaccines, 2) improve existing vaccine formulations, 3) transform the direction of vaccine research by allowing targeting of specific novel pathways identified via VacTrack. Taken together, this proposal holds great potential in advancing the vaccine research to devise new and better vaccines to save and improve human lives on a global level.
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The information about "VACTRACK" are provided by the European Opendata Portal: CORDIS opendata.
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