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SUPD SIGNED

Sizing Up PD: Cavity-enhanced Characterisation of Single Biomarkers in Human Biofluids

Total Cost €

EC-Contrib. €

Partnership

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SUPD project word cloud

Explore the words cloud of the SUPD project. It provides you a very rough idea of what is the project "SUPD" about.

turn spectroscopy movement tools caused pathogenic intermediates therapeutic synuclein monomeric patients cerebral molecular disorder tool clinically protein size causes implicated differ diagnostic proteinaceous intervention misfolds species biophysical disease origins enhanced spinal human employing measuring cure aggregation exceedingly modifying aggregates single structural combining forms form toxicity fluid structure abundance technologies accepted cavity accumulates lewy inclusions molecule healthy cellular disordered parkinson fluorescence techniques brain generate oligomers alpha intrinsically neurodegeneration variability stability bodies termed

Project "SUPD" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	289˙732 €
EC max contribution	289˙732 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2019
Funding Scheme	MSCA-IF-GF
Starting year	2020
Duration (year-month-day)	from 2020-10-01 to 2023-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	289˙732.00
2	THE BOARD OF REGENTS OF THE UNIVERSITY OF WISCONSIN SYSTEM THE BOARD OF REGENTS OF THE UNIVERSITY OF WISCONSIN SYSTEM Organization address address: LINDEN DRIVE 1220 VANHISE HALL 1860 city: MADISON WI postcode: 53706 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (MADISON WI)	partner	0.00

Map

Project objective

Parkinson’s disease is the most common movement disorder caused by neurodegeneration, for which there is no cure, no way of modifying the disease and no clinically accepted diagnostic tool. In the brain, the intrinsically disordered monomeric protein α-synuclein misfolds, aggregates and accumulates to form proteinaceous inclusions termed Lewy bodies. This process forms ‘oligomers’, intermediates in the aggregation pathway that are strongly implicated in the cellular toxicity that causes the disease. Oligomers are exceedingly challenging to study with traditional biophysical techniques because of their low abundance and variability in size, structure and stability. My research proposal aims to develop a new method capable of measuring the size and structural properties of single oligomers in human cerebral spinal fluid. By employing technologies in the field of cavity-enhanced spectroscopy and combining these with existing tools in single-molecule fluorescence I will investigate how the properties of oligomers in cerebral spinal fluid differ between healthy and Parkinson’s disease patients. In order to determine the molecular origins of Parkinson’s disease we need a comprehensive understanding of these pathogenic species. Achieving this goal will enable us to develop an early diagnostic tool which in turn will generate opportunities for therapeutic intervention.

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