Explore the words cloud of the ChirPyr project. It provides you a very rough idea of what is the project "ChirPyr" about.
The following table provides information about the project.
|Coordinator Country||Netherlands [NL]|
|Total cost||177˙598 €|
|EC max contribution||177˙598 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-10-01 to 2019-09-30|
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|1||RIJKSUNIVERSITEIT GRONINGEN||NL (GRONINGEN)||coordinator||177˙598.00|
Pyridine and its derivatives are abundant structural motives in nature and widely used in medicinal chemistry. In this research program we propose to develop catalytic enantioselective methods for the synthesis of chiral pyridines with tertiary and quaternary stereocenters through the catalytic addition of readily available and highly reactive organometallics to conjugated alkenyl pyridines. Furthermore, the proposed methodology will be used for the generation of contiguous stereocenters via sequential conjugate addition/Mg-aza-enolate trapping strategies. The synthesis of this kind of chiral compounds will permit further functionalization of pyridine products through the partial or total hydrogenation reactions of aromatic pyridine rings, or the introduction of different electrophiles in various positions of the aromatic ring.
|year||authors and title||journal||last update|
Denisa VargovÃ¡, Juana M. PÃ©rez, Syuzanna R. Harutyunyan, Radovan Å ebesta
Trapping of chiral enolates generated by Lewis acid promoted conjugate addition of Grignard reagents to unreactive Michael acceptors by various electrophiles
published pages: 11766-11769, ISSN: 1359-7345, DOI: 10.1039/c9cc05041h
|Chemical Communications 55/78||2020-04-08|
Francesco Lanza, Juana PÃ©rez, Ravindra Jumde, Syuzanna Harutyunyan
Lewis Acid Promoted Trapping of Chiral Aza-enolates
published pages: 1253-1262, ISSN: 0039-7881, DOI: 10.1055/s-0037-1611657
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The information about "CHIRPYR" are provided by the European Opendata Portal: CORDIS opendata.
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