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Access to chiral pyridine derivatives via catalytic asymmetric synthesis

Total Cost €


EC-Contrib. €






Project "ChirPyr" data sheet

The following table provides information about the project.


Organization address
address: Broerstraat 5
postcode: 9712CP

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2019-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Pyridine and its derivatives are abundant structural motives in nature and widely used in medicinal chemistry. In this research program we propose to develop catalytic enantioselective methods for the synthesis of chiral pyridines with tertiary and quaternary stereocenters through the catalytic addition of readily available and highly reactive organometallics to conjugated alkenyl pyridines. Furthermore, the proposed methodology will be used for the generation of contiguous stereocenters via sequential conjugate addition/Mg-aza-enolate trapping strategies. The synthesis of this kind of chiral compounds will permit further functionalization of pyridine products through the partial or total hydrogenation reactions of aromatic pyridine rings, or the introduction of different electrophiles in various positions of the aromatic ring.


year authors and title journal last update
List of publications.
2019 Denisa Vargová, Juana M. Pérez, Syuzanna R. Harutyunyan, Radovan Šebesta
Trapping of chiral enolates generated by Lewis acid promoted conjugate addition of Grignard reagents to unreactive Michael acceptors by various electrophiles
published pages: 11766-11769, ISSN: 1359-7345, DOI: 10.1039/c9cc05041h
Chemical Communications 55/78 2020-04-08
2019 Francesco Lanza, Juana Pérez, Ravindra Jumde, Syuzanna Harutyunyan
Lewis Acid Promoted Trapping of Chiral Aza-enolates
published pages: 1253-1262, ISSN: 0039-7881, DOI: 10.1055/s-0037-1611657
Synthesis 51/05 2020-04-08

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