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Human Glymphatics SIGNED

Effects of sleep deprivation and adrenergic inhibition on glymphatic flow in humans

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Human Glymphatics project word cloud

Explore the words cloud of the Human Glymphatics project. It provides you a very rough idea of what is the project "Human Glymphatics" about.

carvedilol    world    risks    noise    severe    cardiac    glymphatic    facilitates    gs    slow    trait    pulsations    brain    demonstrating    forms    integrate    data    determinant    delay    me    function    perfectly    situated    manipulation    sufficient    disease    linked    cognitive    distorted    flow    experts    neuroimaging    alzheimer    rodents    secondly    macroscopic    drive    completion    aliasing    hz    detection    clearance    career    molecular    time    nevertheless    infrastructure    neuropsychology    adrenergic    impairments    exceptional    analyzing    gf    wakefulness    removal    provides    fmri    metabolites    skill    first    foundation    treating    dependent    human    skills    mechanisms    beta    reveal    mri    patient    health    previously    expertise    host    antagonist    sequences    regulation    reduce    independent    respiration    fast    neuroscience    amyloid    disorders    preliminary    ultra    sleep    mr    imaging    chosen   

Project "Human Glymphatics" data sheet

The following table provides information about the project.

Coordinator
REGION HOVEDSTADEN 

Organization address
address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400
website: www.regionh.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-09-23

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 200˙194.00

Map

 Project objective

Sufficient sleep is a key determinant of health, and sleep loss is associated with severe health risks. Nevertheless, the reason for why we sleep is not yet understood. Recently, a molecular function of sleep was described in rodents. The ‘glymphatic system’ (GS) is a sleep dependent macroscopic pathway of the brain that facilitates the removal of metabolites, including amyloid-beta. This project will for the first time reveal a sleep-driven human GS and show whether glymphatic flow (GF) can be linked to cognitive impairments associated with sleep loss. Secondly, I will promote GF with the adrenergic antagonist Carvedilol. This manipulation of glymphatic clearance may define new approaches for treating sleep-disorders and Alzheimer’s disease, or reduce or delay our need for sleep. I will investigate the human GS by applying state of the art, 5-10 Hz, ultra-fast MR sequences across sleep and wakefulness. Preliminary data show that these sequences enable the detection of cardiac, respiration, and slow pulsations, previously considered noise in fMRI imaging and distorted by aliasing effects. These pulsations are now believed to drive GF. The project will be a major step forward for sleep and neuroscience research, but also provide a key step in my career, demonstrating independent work and allowing me to learn advanced data-analysis skills and develop a novel imaging method, which I can apply in future studies. The chosen host institution is perfectly situated for the project, as they have established expertise and an exceptional skill-set in analyzing novel neuroimaging data including ultra-fast MRI. Secondly, my host provides unique infrastructure that allows for completion of the study, with key personnel in neuropsychology and data-analysis, as well as the world leading experts in glymphatic mechanisms. The project forms a foundation for a more general approach to integrate imaging of sleep-regulation and glymphatic mechanisms with patient or trait specific data.

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The information about "HUMAN GLYMPHATICS" are provided by the European Opendata Portal: CORDIS opendata.

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