DIVINOCELL

Exploiting Gram-negative cell division targets in the test tube to obtain anti-microbial compounds

Coordinatore	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS    more  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Mr. Nome: Alberto Sereno Cognome: Alvarez Email: send email Telefono: +34 91 5681704 Fax: +34 91 5668960
Nazionalità Coordinatore	Spain [ES]
Totale costo	8˙149˙653 €
EC contributo	5˙956˙086 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-B
Funding Scheme	CP-FP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-03-01   -   2013-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Mr. Nome: Alberto Sereno Cognome: Alvarez Email: send email Telefono: +34 91 5681704 Fax: +34 91 5668960	ES (MADRID)	coordinator	1˙231˙767.00
2	UNIVERSITY OF NEWCASTLE UPON TYNE  Organization address address: Kensington Terrace 6 city: NEWCASTLE UPON TYNE postcode: NE1 7RU contact info Titolo: Ms. Nome: Nicola Cognome: Place Email: send email Telefono: +44 191 2225324 Fax: +44 191 2225920	UK (NEWCASTLE UPON TYNE)	participant	722˙144.00
3	EVOLVA BIOTECH A/S	DK	participant	673˙160.00
4	UNIVERSITEIT VAN AMSTERDAM  Organization address address: SPUI 21 city: AMSTERDAM postcode: 1012WX contact info Titolo: Mr. Nome: Allard Cognome: De Haart Email: send email Telefono: +31 20 5257261 Fax: +31 20 5257934	NL (AMSTERDAM)	participant	627˙501.00
5	MEDICAL RESEARCH COUNCIL  Organization address address: NORTH STAR AVENUE POLARIS HOUSE city: SWINDON postcode: SN2 1FL contact info Titolo: Ms. Nome: Elizabeth Cognome: Culter Email: send email Telefono: +44 0 1223 402357 Fax: +44 1223 412515	UK (SWINDON)	participant	522˙039.00
6	DEMURIS LIMITED  Organization address address: "c/o FEL ACCOUNTS, THE CRESCENT 23" city: WHITLEY BAY postcode: NE26 2JG contact info Titolo: Dr. Nome: Phillip Cognome: Elstob Email: send email Telefono: +44 191 2464574	UK (WHITLEY BAY)	participant	489˙700.00
7	STICHTING VU-VUMC  Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV contact info Titolo: Dr. Nome: Yvonne Cognome: Kops Email: send email Telefono: 31205987304	NL (AMSTERDAM)	participant	446˙904.00
8	BIOMOL-INFORMATICS SL  Organization address address: CALLE FARADAY -Parque Cientifico- 7 city: MADRID postcode: 28049 contact info Titolo: Ms. Nome: Milagros Cognome: Ruiz Del Peso Email: send email Telefono: +34 647504634 Fax: +34 91 4972401	ES (MADRID)	participant	409˙100.00
9	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Ms. Nome: Liliane Cognome: Flabbée Email: send email Telefono: +33 1 42349454 Fax: +33 1 42349508	FR (PARIS)	participant	346˙630.00
10	VICHEM CHEMIE KUTATO KFT  Organization address address: HERMANN OTTO UTCA 15 city: BUDAPEST postcode: 1022 contact info Titolo: Mr. Nome: Zoltán Cognome: Dobai Email: send email Telefono: +36 1 4872080 Fax: +36 1 4872081	HU (BUDAPEST)	participant	333˙940.00
11	UNIVERSIDAD DE CHILE  Organization address address: Av. Libertador Bernardo O'Higgins 1058 city: SANTIAGO postcode: 10 contact info Titolo: Mr. Nome: Pedro Cognome: Arancibia Email: send email Telefono: +56 2 9787206 Fax: +56 2 2763467	CL (SANTIAGO)	participant	153˙201.00
12	VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG  Organization address address: De Boelelaan 1105 city: AMSTERDAM postcode: 1081 HV contact info Titolo: Mr. Nome: Jaap Cognome: Roos Email: send email Telefono: +31 20 5987234	NL (AMSTERDAM)	participant	0.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'The DIVINOCELL project will identify novel Gram-negative targets by exploiting the components of the divisome, their activities and interactions. It will also design selective assays for screening and will obtain a new class of antimicrobials: compounds to block bacterial division. New medicines to attack Gram-negative pathogens will decrease the burden of infectious disease and have a highly beneficial social and economic impact in Europe and beyond. Cell division is an essential and still underexploited process with excellent properties to yield new inhibitors to attack infection by blocking the proliferation of pathogens. Inhibitors directed against bacterial division targets, that are not present in eukaryotic cells, will be both effective and innocuous to humans and animals. In addition, as many of their structures will be based on interaction domains and synthetic scaffolds, they will generate resistance at levels lower than the present antibiotics. DIVINOCELL will apply existing and new knowledge on the molecular biology of Gram-negative cell division as well as novel analytical (nanodiscs), bioinformatic (molecular dynamics), structural (membrane protein crystals) and imaging (lanthanide staining) tools to exploit in the test tube the structures and interactions of targets in the divisome and the septum. DIVINOCELL will develop potent systematic screening assays and will use them to select compounds specifically tailored to inhibit the division of Gram-negatives (not precluding broad spectrum ones). Secondary activity and cell assays, based on the properties of bacterial division, will be generated to validate hits and advance them to leads. The medicinal properties of selected leads will be improved. The translational steps of the project will be developed by 4 SMEs in close collaboration with the 8 academic partners having well-proven expertise in molecular microbiology, protein chemistry, structural biology, biophysics, imaging and bioinformatics.'

Introduzione (Teaser)

Cell division is an essential process with potential to yield new inhibitors of infection by blocking the proliferation of pathogens. Inhibitors against bacterial targets, that are not present in eukaryotic cells, are both effective and specific.