MAMBA

Marine Metagenomics for New Biotechnological Applications

Coordinatore	BANGOR UNIVERSITY    more  Organization address address: COLLEGE ROAD city: BANGOR postcode: LL57 2DG contact info Titolo: Mr. Nome: Dyfan Cognome: Griffith Email: send email Telefono: +44-1248-38 3264 Fax: +44 1248 38 2042
Nazionalità Coordinatore	United Kingdom [UK]
Sito del progetto	http://mamba.bangor.ac.uk/
Totale costo	4˙978˙203 €
EC contributo	2˙875˙245 €
Programma	FP7-KBBE Specific Programme "Cooperation": Food, Agriculture and Biotechnology
Code Call	FP7-KBBE-2008-2B
Funding Scheme	CP-FP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-07-01   -   2013-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	BANGOR UNIVERSITY  Organization address address: COLLEGE ROAD city: BANGOR postcode: LL57 2DG contact info Titolo: Mr. Nome: Dyfan Cognome: Griffith Email: send email Telefono: +44-1248-38 3264 Fax: +44 1248 38 2042	UK (BANGOR)	coordinator	621˙144.00
2	UNIVERSITE DE BRETAGNE OCCIDENTALE  Organization address address: RUE DES ARCHIVES 3 city: BREST CEDEX 3 postcode: 29238 contact info Titolo: Dr. Nome: Joel Cognome: Querellou Email: send email Telefono: 33-2-98224686 Fax: 33-2-98498705	FR (BREST CEDEX 3)	participant	369˙828.00
3	HEINRICH-HEINE-UNIVERSITAET DUESSELDORF  Organization address address: UNIVERSITAETSSTRASSE 1 city: DUSSELDORF postcode: 40225 contact info Titolo: Mr. Nome: Uwe Cognome: Droste Email: send email Telefono: -12488 Fax: -11652	DE (DUSSELDORF)	participant	369˙750.00
4	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Mr. Nome: Carlos Manuel Cognome: Abad Ruiz Email: send email Telefono: +34 91 566 8852 Fax: +34 91 566 8913	ES (MADRID)	participant	366˙858.00
5	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Mr. Nome: Jean-Michel Cognome: Portefaix Email: send email Telefono: -67613506 Fax: -67043207	FR (PARIS)	participant	363˙089.00
6	CONSIGLIO NAZIONALE DELLE RICERCHE  Organization address address: Piazzale Aldo Moro 7 city: ROMA postcode: 185 contact info Titolo: Ms. Nome: Gaetana Cognome: Irrera Email: send email Telefono: -669054 Fax: -669058	IT (ROMA)	participant	357˙549.00
7	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Ms. Nome: Heike Cognome: Wojack Email: send email Telefono: -2911 Fax: -2990	DE (MUENCHEN)	participant	277˙027.00
8	"PHARMAMAR, S.A.U."  Organization address address: "Avda. de los Reyes , Poligono Industrial La Mina 1" city: COLMENAR VIEJO (MADRID) postcode: 28770 contact info Titolo: Mr. Nome: Guillermo Cognome: Jimenez Díaz Email: send email Telefono: + 34 91 823 4526 Fax: + 34 91 846 6001	ES (COLMENAR VIEJO (MADRID))	participant	50˙000.00
9	evocatal GmbH  Organization address address: Merowingerplatz 1a city: Duesseldorf postcode: 40225 contact info Titolo: Dr. Nome: Thorsten Cognome: Eggert Email: send email Telefono: +49 211 15760950 Fax: -+49 211 15760959	DE (Duesseldorf)	participant	50˙000.00
10	INSTITUT DE RECHERCHE PIERRE FABRESAS  Organization address address: PLACE ABEL GANCE 45 city: BOULOGNE BILLANCOURT postcode: 92100 contact info Titolo: Mr. Nome: Vincent Cognome: Denoel Email: send email Telefono: -534321392 Fax: -534321344	FR (BOULOGNE BILLANCOURT)	participant	50˙000.00
11	THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO  Organization address address: KINGS COLLEGE CIRCLE 27 city: TORONTO postcode: M5S 1A1 contact info Titolo: Ms. Nome: Jennifer Cognome: Macinnis Email: send email Telefono: 416-978-5557 Fax: 416-798-5821	CA (TORONTO)	participant	0.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'The Project aims at the mining of individual enzymes and metabolic pathways from extremophilic marine organisms and the metagenomes from microbial communities from peculiar marine environments and consequent funnelling the new enzymatic reactions and processes towards the new biotechnological applications. Project builds up on the scientific and technological excellence of individual academic and industrial partners, and beyond that, on application of the state-of-the-art technologies for archiving, molecular screening for the activities (using a unique Surface Plasmon Resonance screening platform), protein structure elucidation, enzyme engineering and directed evolution and establishing new biotechnological processes (biocatalysis, synthesis of fine chemicals, etc.). Marine sampling hotspots to produce the metagenomic resources for their further exploration will cover the whole diversity of marine microbial life at its limits (hypersaline, low and high temperature, high pressure and low water activity conditions, etc.). Individual enzymes interacting with the substrates will be identified, and in case they are new, hyperexpressed and crystallized and their structures will be elucidated. Consequently, the most promising candidates will be scored against the chiral substrates of relevance for biocatalysis and their ability to perform in water-free systems will be evaluated, the directed evolution will be implemented to improve the performance, and specificity of the enzymes. A comprehensive bioinformatic survey throughout the whole tree of cellular life will reveal and suggest the new candidates homologous to the discovered new proteins, from other organisms to be cloned and assayed. The implementation of the set of new enzymes in the biotechnological processes for fine chemical synthesis and drug discovery will be conducted in a strong alliance with competent industrial partners.'

Introduzione (Teaser)

Marine microorganisms are a promising and still mostly untapped source of enzymes for commercial use. Now, researchers have developed a way to screen for enzyme activity, finding hundreds of new enzymes in the process.