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MycoSynVac SIGNED

Engineering of Mycoplasma pneumoniae as a broad-spectrum animal vaccine

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MycoSynVac project word cloud

Explore the words cloud of the MycoSynVac project. It provides you a very rough idea of what is the project "MycoSynVac" about.

point engineering gallisepticum peptide difficult multimillion aside reproducible ie vaccines pathogen msd small foreseeable industry wall genome cell humans create rationally acquired highlights sme living display risks euros animal position medium world ideal designing pets mycoplasmas organism meet prepare viruses ultimate metabolic care microorganisms biology cows industrial probably material antibiotics vaccinate free pneumoniae infection hyopneumoniae guided cheap screening pipeline losses specialized 860 infecting starting pigs media data kb livestock contamination species axenic poultry grow irreproducibility mycoplasma bovis culture training resistant synoviae usa commercialization caused vaccine modeling grown lack vaccination animals serum public chassis ethical smallest cow privileged universal infections farm

Project "MycoSynVac" data sheet

The following table provides information about the project.

Coordinator	FUNDACIO CENTRE DE REGULACIO GENOMICA Organization address address: CARRER DOCTOR AIGUADER 88 city: BARCELONA postcode: 8003 website: www.crg.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://www.mycosynvac.eu
Total cost	8˙056˙677 €
EC max contribution	8˙056˙677 € (100%)
Programme	1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
Code Call	H2020-LEIT-BIO-2014-1
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-04-01 to 2020-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACIO CENTRE DE REGULACIO GENOMICA FUNDACIO CENTRE DE REGULACIO GENOMICA Organization address address: CARRER DOCTOR AIGUADER 88 city: BARCELONA postcode: 8003 website: www.crg.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	coordinator	2˙128˙507.00
2	INTERVET INTERNATIONAL BV INTERVET INTERNATIONAL BV Organization address address: WIM DE KORVERSTRAAT 35 city: BOXMEER postcode: 5831 AN website: http://www.intervet.com/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (BOXMEER)	participant	1˙476˙250.00
3	ATG:BIOSYNTHETICS GMBH ATG:BIOSYNTHETICS GMBH Organization address address: WEBERSTRASSE 40 city: MERZHAUSEN postcode: 79249 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MERZHAUSEN)	participant	897˙493.00
4	WAGENINGEN UNIVERSITY WAGENINGEN UNIVERSITY Organization address address: DROEVENDAALSESTEEG 4 city: WAGENINGEN postcode: 6708 PB website: http://www.wageningenur.nl/nl.htm contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (WAGENINGEN)	participant	860˙008.00
5	INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 website: www.inra.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 07)	participant	850˙300.00
6	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	699˙977.00
7	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	591˙750.00
8	BIOFACTION KG BIOFACTION KG Organization address address: KUNDMANNGASSE 39/12 city: WIEN postcode: 1030 website: www.biofaction.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	552˙392.00

Map

Project objective

Mycoplasmas are the smallest cell wall less, free-living microorganisms. The lack of a cell wall makes them resistant to many of the common antibiotics. Every year, infections caused by Mycoplasmas in poultry, cows, and pigs, result in multimillion euros losses in USA and Europe. Currently, there are vaccines against M hyopneumoniae in pigs and M gallisepticum and M synoviae in poultry. However, there is no vaccination against many Mycoplasma species infecting pets, humans and farm animals (ie M bovis cow infection). Mycoplasma species in many cases are difficult to grown in axenic culture and those that grow need a complex media with animal serum. In large scale production of Mycoplasma species for vaccination aside from the high cost of animal serum, more important is the high irreproducibility in the production process and the possible contamination with animal viruses. All this together highlights what European industry needs:i) a defined cheap reproducible medium that is animal serum free and ii) an universal Mycoplasma chassis that could be used in a pipeline to vaccinate against Mycoplasma species, as well as any pathogen. M pneumoniae is an ideal starting point for designing such a vaccine chassis. It has a small genome (860 kb) and it is probably the organism with the most comprehensive systems biology data acquired so far. By genome comparison, metabolic modeling and rationally engineering its genome, we will create a vaccine chassis that will be introduced into an industrial pipeline. The process will be guided by the second world largest industry on animal vaccination (MSD), as well as a SME specialized on peptide display and screening. This will ensure the exploitation and commercialization of our work contributing to maintain Europe privileged position in this field. Our ultimate goal is to meet the needs of the livestock industry,taking care of ethical issues, foreseeable risks, and prepare effective dissemination and training material for the public.

Deliverables

List of deliverables.
Science game	Websites, patent fillings, videos etc.	2020-04-22 09:58:36
Public and expert concerns	Documents, reports	2020-04-22 09:58:36
Ethical framework	Documents, reports	2020-04-22 09:58:36
Empirical and ethical studies	Documents, reports	2020-04-22 09:58:35
Lorentz Workshop on Whole Cell modeling	Documents, reports	2020-04-22 09:58:35
Project website	Websites, patent fillings, videos etc.	2020-04-22 09:58:35

Take a look to the deliverables list in detail: detailed list of MycoSynVac deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	Eva Yus, Jae-Seong Yang, AdriÃ Sogues, Luis Serrano A reporter system coupled with high-throughput sequencing unveils key bacterial transcription and translation determinants published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00239-7	Nature Communications 8/1	2020-04-22
2017	Marie Trussart, Eva Yus, Sira Martinez, Davide BaÃ¹, Yuhei O. Tahara, Thomas Pengo, Michael Widjaja, Simon Kretschmer, Jim Swoger, Steven Djordjevic, Lynne Turnbull, Cynthia Whitchurch, Makoto Miyata, Marc A. Marti-Renom, Maria Lluch-Senar, LuÃs Serrano Defined chromosome structure in the genome-reduced bacterium Mycoplasma pneumoniae published pages: 14665, ISSN: 2041-1723, DOI: 10.1038/ncomms14665	Nature Communications 8	2020-04-22
2018	Robert W. Smith, Rik P. van Rosmalen, Vitor A. P. Martins dos Santos, Christian Fleck DMPy: a Python package for automated mathematical model construction of large-scale metabolic systems published pages: , ISSN: 1752-0509, DOI: 10.1186/s12918-018-0584-8	BMC Systems Biology 12/1	2020-04-22
2018	Niels Zondervan, Jesse van Dam, Peter Schaap, Vitor Martins dos Santos, Maria Suarez-Diez Regulation of Three Virulence Strategies of Mycobacterium tuberculosis: A Success Story published pages: 347, ISSN: 1422-0067, DOI: 10.3390/ijms19020347	International Journal of Molecular Sciences 19/2	2020-04-22
2017	Tjerko Kamminga, Simen-Jan Slagman, Jetta J. E. Bijlsma, Vitor A. P. Martins dos Santos, Maria Suarez-Diez, Peter J. Schaap Metabolic modeling of energy balances in Mycoplasma hyopneumoniae shows that pyruvate addition increases growth rate published pages: , ISSN: 0006-3592, DOI: 10.1002/bit.26347	Biotechnology and Bioengineering	2020-04-22
2015	Maria Lluch-Senar, Luca Cozzuto, Jaime Cano, Javier Delgado, VerÃ³nica LlÃ³rens-Rico, Sabine Pereyre, CÃ©cile Bebear, Luis Serrano Comparative â€œ-omicsâ€ in Mycoplasma pneumoniae Clinical Isolates Reveals Key Virulence Factors published pages: e0137354, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0137354	PLOS ONE 10/9	2020-04-22
2016	Iason Tsarmpopoulos, GÃ©raldine Gourgues, Alain Blanchard, Sanjay Vashee, Joerg Jores, Carole Lartigue, Pascal Sirand-Pugnet In-Yeast Engineering of a Bacterial Genome Using CRISPR/Cas9 published pages: 104-109, ISSN: 2161-5063, DOI: 10.1021/acssynbio.5b00196	ACS Synthetic Biology 5/1	2020-04-22
2016	Ivan Junier, E.Â Besray Unal, Eva Yus, VerÃ³nica LlorÃ©ns-Rico, Luis Serrano Insights into the Mechanisms of Basal Coordination of Transcription Using a Genome-Reduced Bacterium published pages: 391-401, ISSN: 2405-4712, DOI: 10.1016/j.cels.2016.04.015	Cell Systems 2/6	2020-04-22
2017	Tjerko Kamminga, Jasper J. Koehorst, Paul Vermeij, Simen-Jan Slagman, Vitor A. P. Martins dos Santos, Jetta J. E. Bijlsma, Peter J. Schaap Persistence of Functional Protein Domains in Mycoplasma Species and their Role in Host Specificity and Synthetic Minimal Life published pages: , ISSN: 2235-2988, DOI: 10.3389/fcimb.2017.00031	Frontiers in Cellular and Infection Microbiology 7	2020-04-22
2016	Maria Lluch-Senar, Francesco M. Mancuso, HÃ©ctor Climente-GonzÃ¡lez, Marcia I. PeÃ±a-Paz, Eduard Sabido, Luis Serrano Rescuing discarded spectra: Full comprehensive analysis of a minimal proteome published pages: 554-563, ISSN: 1615-9853, DOI: 10.1002/pmic.201500187	PROTEOMICS 16/4	2020-04-22
2016	Wei-Hua Chen, Vera vanÂ Noort, Maria Lluch-Senar, Marco L. Hennrich, Judith A. H.Â Wodke, Eva Yus, Andreu AlibÃ©s, Guglielmo Roma, Daniel R. Mende, Christina Pesavento, Athanasios Typas, Anne-Claude Gavin, Luis Serrano, Peer Bork Integration of multi-omics data of a genome-reduced bacterium: Prevalence of post-transcriptional regulation and its correlation with protein abundances published pages: 1192-1202, ISSN: 0305-1048, DOI: 10.1093/nar/gkw004	Nucleic Acids Research 44/3	2020-04-22
2018	Rienk A. Rienksma, Peter J. Schaap, Vitor A. P. Martins dos Santos, Maria Suarez-Diez Modeling the Metabolic State of Mycobacterium tuberculosis Upon Infection published pages: , ISSN: 2235-2988, DOI: 10.3389/fcimb.2018.00264	Frontiers in Cellular and Infection Microbiology 8	2020-04-22
2018	Lei Pei, Markus Schmidt Fast-Growing Engineered Microbes: New Concerns for Gain-of-Function Research? published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00207	Frontiers in Genetics 9	2020-04-22

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