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NOVA SIGNED

Non-coding RNA in Vascular Ageing

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

NOVA project word cloud

Explore the words cloud of the NOVA project. It provides you a very rough idea of what is the project "NOVA" about.

functions cardiovascular attenuate age molecular vitro rising lncrnas coding rnas disease organisms union concomitantly mechanisms experiments h19 stroke vivo lncrna yield cellular disorders cells infarction acute models expectancy myocardial gain vascular life prevalence understand endothelial hypertension underlying dysfunction function hallmark regulated overlooked highlight aging play vasculature regulators therapeutic hypothesize extensively young endothelium preliminary

Project "NOVA" data sheet

The following table provides information about the project.

Coordinator	JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN Organization address address: THEODOR W ADORNO PLATZ 1 city: FRANKFURT AM MAIN postcode: 60323 website: www.uni-frankfurt.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.boonlab.eu
Total cost	1˙499˙693 €
EC max contribution	1˙499˙693 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2015
Duration (year-month-day)	from 2015-04-01 to 2021-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN Organization address address: THEODOR W ADORNO PLATZ 1 city: FRANKFURT AM MAIN postcode: 60323 website: www.uni-frankfurt.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	coordinator	1˙499˙693.00

Map

Project objective

Life expectancy in the European Union is rising and the prevalence of age-induced cardiovascular disease increases concomitantly. Endothelial dysfunction is a hallmark of aging in the vasculature and is the underlying cause of many cardiovascular disorders, like hypertension, acute myocardial infarction and stroke. This proposal aims to better understand the molecular mechanisms behind aging that lead to endothelial dysfunction. Non-coding RNAs are emerging as novel key regulators of cellular functions and we hypothesize that non-coding RNAs contribute to vascular aging. Preliminary experiments show that several long non-coding RNAs (lncRNAs) are regulated during aging of the cardiovascular system, including the lncRNA H19. We propose to extensively characterize the role of H19 in endothelial aging and to identify other lncRNAs that are involved in vascular aging. We will use state-of-the-art in vitro and in vivo models to assess endothelial aging and function upon gain-of-function and loss-of-function of lncRNAs. Understanding the role that H19 and other lncRNAs play in aging endothelium will highlight novel potential therapeutic targets to attenuate age-induced endothelial dysfunction. The focus on aging will also yield insight in molecular mechanisms that may have been overlooked when studying endothelial function in young cells or organisms.

Publications

List of publications.
year	authors and title	journal	last update
2018	Philipp Neumann, Nicolas JaÃ©, Andrea Knau, Simone F. Glaser, Youssef Fouani, Oliver Rossbach, Marcus KrÃ¼ger, David John, Albrecht Bindereif, Phillip Grote, Reinier A. Boon, Stefanie Dimmeler The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2 published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02431-1	Nature Communications 9/1	2020-01-30
2016	Reinier A. Boon, Patrick Hofmann, Katharina M. Michalik, Noelia Lozano-Vidal, Denise BerghÃ¤user, Ariane Fischer, Andrea Knau, Nicolas JaÃ©, Christoph SchÃ¼rmann, Stefanie Dimmeler Long Noncoding RNA Meg3 Controls Endothelial Cell Aging and Function published pages: 2589-2591, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2016.09.949	Journal of the American College of Cardiology 68/23	2019-12-09
2016	Reinier A. Boon, Nicolas JaÃ©, Lesca Holdt, Stefanie Dimmeler Long Noncoding RNAs published pages: 1214-1226, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2015.12.051	Journal of the American College of Cardiology 67/10	2019-12-09
2018	Kosta Theodorou, Reinier A. Boon Endothelial Cell Metabolism in Atherosclerosis published pages: , ISSN: 2296-634X, DOI: 10.3389/fcell.2018.00082	Frontiers in Cell and Developmental Biology 6	2019-12-09
2018	Patrick Hofmann, Janina Sommer, Kosta Theodorou, Luisa Kirchhof, Ariane Fischer, Yuhuang Li, Ljubica Perisic, Ulf Hedin, Lars Maegdefessel, Stefanie Dimmeler, Reinier A Boon Long non-coding RNA H19 regulates endothelial cell aging via inhibition of STAT3 signalling published pages: 230-242, ISSN: 0008-6363, DOI: 10.1093/cvr/cvy206	Cardiovascular Research 115/1	2019-12-09

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The information about "NOVA" are provided by the European Opendata Portal: CORDIS opendata.