In neuronal networks of the brain, synapses are the connection points between neurons. The dynamics (or plasticity) of these synapses allow us to think, learn and memorize. A deeper understanding of these phenomena requires investigations of single synapses. Synapses have been intensively studied in vivo but in such studies the physiological complexity limits the investigations at the single synapses level.
Despite tremendous technical and conceptual advances of in vivo studies, we miss (1) a better understanding of the mechanics of synapses formation; (2) observing directly the chemical activity at single synapses; (3) investigating the role of neuronal network topology in synaptic plasticity. These classical limitations can now be overcome by alternative in vitro approaches, using recent technological advances in microfluidics and nano-technologies.
The aim of NANOSYNNETS is to use vertical arrays of NANOwires (aNWs) to study in vitro the formation and plasticity of single SYnapses in Neuronal NETworkS with controlled topologies.
With my expertise in growing controlled neuronal networks in microfluidic chips, I decided to join the one of the leading group in bio-nanotechnologies, lead by Karen Martinez (KM) and based at the NanoScience Center (NSC) of the University of Copenhagen (UCPH), to exploit novel technologies for the investigation of in vitro single synapse formation, activity and plasticity. This novel approach will give a complementary and cutting-edge point of view to classical in vivo studies of synapses and will thereby provide unmatched insights into neurobiology and will shed new lights on unanswered questions in learning mechanisms or neuronal communication.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NANOSYNNETS" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "NANOSYNNETS" are provided by the European Opendata Portal: CORDIS opendata.
More projects from the same programme (H2020-EU.1.3.2.)
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