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BIOCAPAN SIGNED

BIOactive implantable CApsule for PANcreatic islets immunosuppression free therapy

Total Cost €

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EC-Contrib. €

0

Partnership

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Outcomes and
results

BIOCAPAN project word cloud

Explore the words cloud of the BIOCAPAN project. It provides you a very rough idea of what is the project "BIOCAPAN" about.

encapsulated implanting injections accordance microenvironment therapy frequent tremendous tremendously strategies six islet experts protecting encapsulation lifelong transplantation issue reduces gmp modulation quality insulin microencapsulation unprotected provisions administration grafts reconstruction protect benefit maximize patients islets diabetes protocol innovative fibrotic start pericapsular implantation glycaemic microfluidic situ clinical prevention shown validation option full limits complete free biocapan regulation adverse preclinical complications matrix mellitus reductions allogeneic harvested refresher constant reactions overgrowth cells bioactive freshly glycaemia survival reproducible pancreatic treatment extend extracellular therapeutic immune implantations maximum standardized self medicinal microcapsule grade immunosuppressants applicability injection life oxygenation platform trials

Project "BIOCAPAN" data sheet

The following table provides information about the project.

Coordinator	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 website: www.cea.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	http://www.biocapan.eu
Total cost	7˙998˙875 €
EC max contribution	7˙998˙875 € (100%)
Programme	1. H2020-EU.2.1.3.1. (Cross-cutting and enabling materials technologies)
Code Call	H2020-NMP-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-06-01 to 2019-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 website: www.cea.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS 15)	coordinator	1˙988˙570.00
2	UNIVERSITE CATHOLIQUE DE LOUVAIN UNIVERSITE CATHOLIQUE DE LOUVAIN Organization address address: PLACE DE L UNIVERSITE 1 city: LOUVAIN LA NEUVE postcode: 1348 website: www.uclouvain.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LOUVAIN LA NEUVE)	participant	1˙364˙915.00
3	CHARITE - UNIVERSITAETSMEDIZIN BERLIN CHARITE - UNIVERSITAETSMEDIZIN BERLIN Organization address address: Chariteplatz 1 city: BERLIN postcode: 10117 website: www.charite.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	1˙194˙291.00
4	NANOIMMUNOTECH SL NANOIMMUNOTECH SL Organization address address: EDIFICIO CITEXVI C FONTE DAS ABELLE SN CAMPUS UNIVERSITARIO DE VIGO city: VIGO PONTEVEDRA postcode: 36310 website: www.nanoimmunotech.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VIGO PONTEVEDRA)	participant	853˙225.00
5	UNIVERSITE GRENOBLE ALPES UNIVERSITE GRENOBLE ALPES Organization address address: 621 AVENUE CENTRALE city: GRENOBLE postcode: 38058 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (GRENOBLE)	participant	783˙878.00
6	WAKE FOREST UNIVERSITY HEALTH SCIENCES WAKE FOREST UNIVERSITY HEALTH SCIENCES Organization address address: MEDICAL CENTER BOULEVARD city: WINSTON SALEM NC postcode: 27157 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (WINSTON SALEM NC)	participant	764˙918.00
7	ETABLISSEMENT FRANCAIS DU SANG ETABLISSEMENT FRANCAIS DU SANG Organization address address: AVENUE DU STADE DE FRANCE 20 city: LA PLAINE SAINT DENIS postcode: 93210 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LA PLAINE SAINT DENIS)	participant	652˙940.00
8	FMC BIOPOLYMER AS FMC BIOPOLYMER AS Organization address address: INDUSTRIVEIEN 33 city: SANDVIKA postcode: 1337 website: www.fmcbiopolymer.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (SANDVIKA)	participant	236˙861.00
9	EUROPEAN RESEARCH SERVICES GMBH EUROPEAN RESEARCH SERVICES GMBH Organization address address: ROENTGENSTRASSE 19 city: MUENSTER postcode: 48149 website: www.european-research-services.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENSTER)	participant	159˙275.00
10	UNIVERSITE GRENOBLE ALPES UNIVERSITE GRENOBLE ALPES Organization address address: 621, AVENUE CENTRALE city: SAINT MARTIN D'HERES postcode: 38401 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (SAINT MARTIN D'HERES)	participant	0.00
11	UNIVERSITE JOSEPH FOURIER GRENOBLE 1 UNIVERSITE JOSEPH FOURIER GRENOBLE 1 Organization address address: Avenue Centrale, Domaine Universitaire 621 city: GRENOBLE postcode: 38041 website: www.ujf-grenoble.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (GRENOBLE)	participant	0.00

Map

Project objective

The key therapeutic issue in diabetes mellitus type I and II is glycaemic control. Reductions of constant self-control, of insulin injections, and of long-term complications would have tremendous benefit for quality of life. The best therapy option is the transplantation of allogeneic islet cells, but the current state of the art limits the applicability of this approach. Implanting unprotected grafts requires lifelong administration of immunosuppressants, and protecting the cells against adverse immune reactions by current encapsulation strategies reduces their functionality and survival to an extend that makes frequent ‘refresher’ implantations necessary. Currently, a maximum of 2 years glycaemia regulation has been shown for the encapsulated approach.

In BIOCAPAN, bringing experts from different fields all together, we aim at developing an innovative treatment, based on the implantation of allogeneic islet cells that are embedded in a complex microcapsule. We will design a GMP-grade bioactive microcapsule that will maximize the long-term functionality and survival of pancreatic islets by prevention of pericapsular fibrotic overgrowth, in situ oxygenation, innovative extracellular matrix microenvironment reconstruction and immune-system modulation. We will establish a GMP-grade microfluidic microencapsulation platform to protect freshly harvested islets quickly in a standardized and reproducible way.

We aim for full preclinical validation and we will establish a complete protocol in accordance with the provisions of the Advanced Therapy Medicinal Products Regulation, in order to start clinical trials within one year after the end of the project. We aim for 5-years insulin injection free treatment, without immunosuppressants, which would tremendously benefit diabetes mellitus patients who require insulin (all Type I and about one in six Type II Diabetes Mellitus patients).

Deliverables

List of deliverables.
Demonstrator	Demonstrators, pilots, prototypes	2020-04-01 18:38:32
Website and flyer	Websites, patent fillings, videos etc.	2020-04-01 18:38:32

Take a look to the deliverables list in detail: detailed list of BIOCAPAN deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Camille Laporte, Emily Tubbs, Justine Cristante, Anne-Sophie Gauchez, Sandra Pesenti, FrÃ©dÃ©ric Lamarche, CÃ©cile Cottet-Rousselle, Catherine Garrel, Anaick Moisan, Jean-Marc Moulis, Eric Fontaine, Pierre-Yves Benhamou, Sandrine Lablanche Human mesenchymal stem cells improve rat islet functionality under cytokine stress with combined upregulation of heme oxygenase-1 and ferritin published pages: , ISSN: 1757-6512, DOI: 10.1186/s13287-019-1190-4	Stem Cell Research & Therapy 10/1	2020-04-01

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The information about "BIOCAPAN" are provided by the European Opendata Portal: CORDIS opendata.

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