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H2020 projects about "extracellular"

The page lists 222 projects related to the topic "extracellular".

# achronym  title  year 
1 COMPUCELL Autonomous Cellular Computers for Diagnosis 2015
2 PentaBrain Structural studies of mammalian Cys-loop receptors 2015
3 ANISOGEL Injectable anisotropic microgel-in-hydrogel matrices for spinal cord repair 2015
4 BacBio Mechanistic and functional studies of Bacillus biofilms assembly on plants, and their impact in sustainable agriculture and food safety 2015
5 Rethyming Rebuilding the human thymus to create a tolerising system for allogeneic tissue and organ transplantation 2015
6 BIOGEL Engineering responsive and biomimetic hydrogels for biomedical therapeutic and diagnostic applications 2015
7 ECMED The Extracellular Matrix in Epileptogenesis 2015
8 MATRIXASSAY Novel Cell Migration Assay Based on Microtissue Technology and Tissue-Specific Matrices 2015
9 GLYCANC Matrix glycans as multifunctional pathogenesis factors and therapeutic targets in cancer 2015
10 VIVOIMAG Multimodal imaging of the in vivo fate of bone transplants 2015
11 BAS-SBBT Bacterial Amyloid Secretion: Structural Biology and Biotechnology. 2015
12 TRYP-QS YAK kinase regulated trypanosome quorum sensing 2015
13 PERFECTION Probing mechanisms of pathogen effector recognition by plant Resistance proteins to elevate defence gene activation 2016
14 IMSTREV Immune modulation by lymph node stromal cell-derived extracellular vesicles 2015
15 TANYFEEDNEURONS Gliotransmission and shuttling of metabolic signals to feeding neuronal circuits by tanycytes 2015
16 HspAdhesion Role of cell membrane associated Hsp70 in cancer cell adhesion and metastasis 2015
17 embryonic rosettes Investigating embryonic development at the time of implantation using embryos and ES cells 2016
18 MYO-DESMOPLASIA Modulating the behaviour of cancer myofibroblasts to control tumour desmoplasia 2015
19 MIP4CELL Molecular Imprinting mediated regulation of cell behavior and related biomedical applications 2016
20 Magnetic HEART Targeting the Human Myocardial Remodeling Process Using Novel Magnetic Force-Based Human Heart Tissue 2016
21 Subpopulations Investigating Fibrotic and Regenerative Fibroblast Populations in Muscular Dystrophy 2016
22 miRNAs in TH2 cells Role of extracellular miRNAs in T cell development, TH2 cell differentiation and TH2 cell-mediated effector function 2015
23 MatrixMacrophages Matrix degrading macrophages in cancer growth and invasion 2015
24 ISPADMEC Integrin specificity in rigidity sensitive proliferation, activation and directional migration of endothelial cells 2015
25 AMIABLE Advanced MIcroscopy of Attine ant BacteriaL Endosymbionts 2015
26 Beta-splicenet ALTERNATIVE SPLICING NETWORKS IN PANCREATIC BETA CELLS 2015
27 REBuILD Exploring the role of TFEB in exosome biology and in novel approaches for treatment of lysosomal diseases 2016
28 AuxinER Mechanisms of Auxin-dependent Signaling in the Endoplasmic Reticulum 2015
29 ELASTISLET Tailored Elastin-like Recombinamers as Advanced Systems for Cell Therapies in Diabetes Mellitus: a Synthetic Biology Approach towards a Bioeffective and Immunoisolated Biosimilar Islet/Cell Niche 2015
30 LONGHEART Exploring selected long non-coding RNAs as diagnostics and therapeutic targets for heart failure 2015
31 PREVENT Prostate cancer extracellular vesicles as biomarkers for nanomedicine treatment 2015
32 BIOCAPAN BIOactive implantable CApsule for PANcreatic islets immunosuppression free therapy 2015
33 JointPrinting 3D Printing of Cell Laden Biomimetic Materials and Biomolecules for Joint Regeneration 2015
34 PLANTSTEMS Decoding the Lateral Expansion of Plant Stems 2015
35 miRNA in Immunity Testing the role of miRNA-mediated non-cell autonomous gene regulation in type-2 immunity 2015
36 Cancer-Recurrence Tumor cell death supports recurrence of cancer 2015
37 SYSMET Systems Biology of Membrane Trafficking 2016
38 SYNECT Immunological synapse derived ectosomes in T cell effector function 2015
39 RUBICON Training network for Research on molecUlar and Biomechanical Interactions in CONnective tissue disorders 2016
40 MAIN Molecular Adhesion and Interactions in the Nervous system 2016
41 SVDs-at-target Small vessel diseases in a mechanistic perspective: Targets for Intervention Affected pathways and mechanistic exploitation for prevention of stroke and dementia 2016
42 GLION Investigating glial glycogen utilization for ion homeostasis in the brain and its relevance to epileptogenesis: electrophysiology and pharmacology in awake behaving mice 2016
43 ENHANCE Engineering the 3D Niche to enHANCE functionality of hepatocytes derived from human iPSCs 2016
44 CA3RECURRENTPLASTIC In vivo dynamics and plasticity of networks within CA3 of the hippocampus: effects of optogenetic stimulation and natural learning. 2016
45 CollBioImag Development of a cell-based system for high-throughput screening of antifibrotics 2016
46 Expectancy Unveiling expectancy neuronal coding in the cerebral cortex induced by naturalistic tactile stimuli 2017
47 MCANALSMSCA2015 Receptor signalling in space and time - Gaining high-resolution information of the temporal and spatial control of G protein-coupled receptor signalling. 2018
48 SKINFRET The involvement of epidermal stem cells in spatiotemporal ERK activity propagation 2016
49 ENDYVE ENgineering DYnamic ViscoElasticity to study cell response 2016
50 Exosomes Regulated secretion and role of urinary nanovesicles 2017
51 PepPtNPAntiCan Peptide Coated Platinum Nanoparticles as Antitumor Agents 2016
52 PERICYTEStroma Pericyte-derived tumor stroma – a target for cancer therapy 2016
53 MECHANOCHECK ATR-mediated mechanotransduction and connections with the actin cytoskeleton 2016
54 STrkB The structural biology of TrkB-BDNF signalling 2017
55 CORA Copper Acquisition 2016
56 MuCellWall Seed mucilage envelope as a new structural model in cell wall research 2016
57 THaCH The effects of hypercholesterolemia on tendon health (Tendon Health and CHolesterol) 2016
58 Lumiblast A paradigm shift in cancer therapy – using mitochondria-powered chemiluminescence to non-invasively treat inaccessible tumours 2016
59 SugarBlock Unraveling the protein glycosylation of Plasmodium falciparum is crucial for development of novel therapeutics against malaria 2016
60 PARAGEN Biomaterials with incorporated MSC-secreted PARAcrine molecules for bone reGENeration 2017
61 MicroNICHE Microfluidic-assisted fabrication of artifical microniches for bone marrow stem cells 2016
62 MechBiolRep Mechanobiology of Bovine Reproduction 2016
63 HIRESMEMMANIP Spiking network mechanisms underlying short term memory 2016
64 OPTIMIsE Commercial feasibility of the Novio-PlainGel: a novel synthetic, reversible thermosensitive, biomimetic hydrogel for organoid-based precision medicine 2016
65 C.NAPSE TOWARDS A COMPREHENSIVE ANALYSIS OF EXTRACELLULAR SCAFFOLDING AT THE SYNAPSE 2016
66 MATRICAN Matrix during cancer progression 2016
67 CoCa Collagen in Cancer: from the regulatory fibril forming function of collagen V in development to its implication in tumor progression 2016
68 CholAminCo Synergy and antagonism of cholinergic and dopaminergic systems in associative learning 2017
69 RADoTE Remote-Activated Delivery of Therapeutic Exosomes (RADoTE) via an Injectable PEG Hydrogel Carrier 2016
70 SEMA3C Genetic dissection of the SEMA3C/Neuropilin 1 signalling pathway in Chronic Kidney Disease progression 2016
71 MMA Molecular Mechanical Adhesives 2017
72 SWEETBULLETS Sweet Theranostics in Bitter Infections - Seek and Destroy 2017
73 B-SMART Brain-Specific, Modular and Active RNA Therapeutics 2017
74 EVALVE Biomechanics and signaling in models of congenital heart valve defects 2016
75 CAVEHEART Heart regeneration in the Mexican cavefish: The difference between healing and scarring 2017
76 FORMAT FORMAT: a novel medium FOr Revolutionizing stem cell MAnufacturing Technologies 2017
77 BONEPHAGY Defining the role of the FGF – autophagy axis in bone physiology 2017
78 EVOLVE Extracellular Vesicle-Internalizing Receptors (EVIRs) for Cancer ImmunoGeneTherapy 2017
79 SynchroSelf Harnessing reversibility of peptide Self-Assembly processes to Synchronise Extracellular Matrix substitutes with cellular driven tissue reconstruction 2016
80 NEOFIBRIN Advanced material for the regeneration of oral mucosa injuries 2017
81 LamelliActin Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells 2017
82 Plat-IL-1 Pathophysiology of platelet-derived Interleukin 1 2017
83 Survive Surviving metabolism: acid handling and signalling 2017
84 MELBA MEMBRANE PROTEINS OF ELECTROACTIVE BACTERIA PROBED AT LIPID LAYERS ONTO MODIFIED ELECTRODES 2017
85 ZINCLAPS Light-addressable potentiometric sensors (LAPS) for zinc imaging with high spatiotemporal resolution for elucidating the role of zinc in age related macular degeneration. 2017
86 PhySense Physarum Sensor: Biosensor for Citizen Scientists 2017
87 Cytokine Signalosome Mapping Cytokine Signalling Networks using Engineered Surrogate Ligands 2017
88 GRADIENTSENSING Cellular navigation along spatial gradients 2017
89 FiTTeR Developing a Fibrosis Targeting and Tissue Reparative (FiTTeR) Therapy for the Infarcted Myocardium via an Injectable Functionalized Extracellular Matrix Hydrogel 2017
90 PROM Pregnancy and Reproduction Organ-on-a-chip Models 2017
91 NanoALS Nanoparticle-based immunization, a novel therapeutic strategy for amyotrophic lateral sclerosis 2018
92 ExItALS RNA-mediated intercellular miscommunication: role of extracellular vesicle cargos in Amyotrophic Lateral Sclerosis 2017
93 WallWatchers Plant cell wall communication and remodelling: the wall watchers. 2017
94 COTETHERS Molecular characterization of vesicle tethering complexes as novel regulators of collagen trafficking 2017
95 AstroModulation Astroglial control of axonal excitability, adaptation and analogue signalling 2017
96 EXO-EYE Stem Cell-Derived Exosomes for the treatment of Traumatic and Degenerative Eye Disease 2017
97 BrainPredictDynamics Temporal predictions in the auditory cortex: neural mechanisms and their specificity across species and stimulus domains 2018
98 VWF and NETs Investigating the interplay between VWF, platelets, and neutrophil extracellular traps in pathologies involving thrombosis of the microvasculature 2017
99 MIDAS Predictive modelling of GPCR druggable allosteric sites 2017
100 EV-LNC Extracellular vesicle-mediated delivery of long non-coding RNA: Implications for vascular repair and regeneration 2017
101 ONCOSYSTEMS Phenotypic characterization of Liver-derived exosomes populations associated with liver metastasis in pancreatic cancers 2017
102 Vis-a-Vis Collective Infectious Units and the Social Evolution of Viruses 2017
103 ECM_INK Cells-self Extracellular Matrices-based Bioinks to create accurate 3D diseased skin tissue models 2017
104 ACTICELL Precision confiner for mechanical cell activation 2017
105 TransfoPneumo Structure and Function of the Bacterial Transformasome 2017
106 HoldCancerBack What Holds Cancer Cells Back? 2017
107 MECHADIAN Mechanobiology of the cellular circadian clock 2018
108 VOLSIGNAL Volume regulation and extracellular signalling by anion channels 2017
109 IBIS Platform for label-free quantitative detection of single proteins and extracellular vesicles 2017
110 FRONTHAL Specificity of cortico-thalamic interactions and its role in frontal cortical functions 2017
111 P-TEV Personalized Tissue-Engineered Veins as the first Cure for Patients with Chronic Venous Insufficiency 2017
112 TRAIN-EV Training in Extracellular Vesicles: for benefit in Health and Disease 2017
113 EVICARE Extracellular Vesicle-Inspired CArdiac Repair 2017
114 ArthroDUR Bifunctional and regeneratively active biomaterial: Towards an ultimate solution for osteoarthritis treatment 2017
115 ImPRESS Imaging Perfusion Restrictions from Extracellular Solid Stress 2018
116 5D Heart Patch A Functional, Mature In vivo Human Ventricular Muscle Patch for Cardiomyopathy 2017
117 EXOGENESIS Syntenin-phosphatidic acid interaction in exosome biogenesis and cell-cell communication: a structure-function based approach 2018
118 BioMatrix Structural Biology of Exopolysaccharide Secretion in Bacterial Biofilms 2018
119 PyraSig Pyrazine Signalling in Commensal and Pathogenic Bacteria 2018
120 INTERCELLMED SENSING CELL-CELL INTERACTION HETEROGENEITY IN 3D TUMOR MODELS:TOWARDS PRECISION MEDICINE 2018
121 ANCHOR Articular cartilage regeneration through the recruitment of bone marrow derived mesenchymal stem cells into extracelluar matrix derived scaffolds anchored by 3D printed polymeric supports 2018
122 UFLNMR Ultrafast Laplace NMR 2018
123 MetaRegulation Metabolic regulation of metastatic growth 2018
124 ROCKSOFT Rho GTPase cross-talk with syndecan-4 regulates pro-fibrotic mechanotransduction in the heart 2019
125 NEUROGUIDE Study of neuronal sensing and migration/guidance dynamics in neurodevelopmental disorders by nano-engineered chips 2018
126 MaGMa Applying Metabolomics to Unveil follow-up treatment biomarkers and Identify Novel TherapeuticTargets in Glioblastoma 2018
127 FatTryp Exploring the hidden life of African trypanosomes: parasite fat tropism and implications for disease 2018
128 ProLiCell Engineered Protein Nanosheets at Liquid-Liquid Interfaces for Stem Cell Expansion, Sorting and Tissue Engineering 2018
129 VERA VERA: Extracellular VEsicles, miRNAs and particulate Air pollution: developing a new tool to identify subjects with high exposure-associated cardiovascular risk 2018
130 NaKStruc Structural studies of Na,K-ATPase isoforms and mutants 2018
131 ASTRO_ECM Deciphering the role of astrocytes in chronic depression. 2018
132 SUPRAforORGANS Synthetic supramolecular polymers as artificial extracellular matrix for stem cell expansion towards organoids. 2019
133 FA x Force Reconstitution and Structural Analysis of a Minimal Mechanosensitive Focal Adhesion Complex 2019
134 TFs-HSCs The identification of the Combinatorial Transcription Factor network exerting different roles in Hematopoietic Stem Cells. 2019
135 AMNEsIA Interactions of amyloid peptides with the neuronal membrane interface: molecular mechanisms involved in Alzheimer’s disease 2018
136 SOCELL Self-organized biomolecular gradients for controlling cellular behaviour in cell culture 2018
137 COAGULANT CK2-dependent cytoskeletal regulation and molecular signaling of Neutrophil Extracellular Trap (NET) formation 2018
138 OPTOLEADER Optogenetic control of leader cell mechanobiology during collective cell migration 2019
139 MEXOM Development and characterization of extracellular vesicles an innovative cell-free therapeutical product for treatment of stroke 2018
140 MECHANOSITY Mechanical regulation of cellular behaviour in 3D viscoelastic materials 2019
141 nanoTOM Conversion of natural plant nanovesicles into nutraceutical delivery system 2018
142 FUCTURE Fucosylated Clusterin: a novel mechanism of tumor escape from immune response 2018
143 GENOMIA Genomic Modifiers of Inherited Aortapathy 2019
144 BIORECAR Direct cell reprogramming therapy in myocardial regeneration through an engineered multifunctional platform integrating biochemical instructive cues 2018
145 PathEVome Do Pathogen Extracellular Vesicles Deliver Crop Disease? 2018
146 SYNMAT Synthesis of Functional Multi-Component Supramolecular Systems and Materials 2018
147 SENSATIONAL TETHERS Tethers for sensory mechanotransduction: from molecules to perception 2018
148 CERVINO Can human embryo-released extracellular vesicles govern endometrial receptivity and inform on vanguard embryo diagnostics and fertility therapeutics? 2018
149 EDIT Novel precision technological platforms to promote non-invasive early diagnosis, eradication and prevention of cancer relapse: proof of concept in the bladder carcinoma. 2018
150 VES4US Extracellular vesicles from a natural source for tailor-made nanomaterials 2018
151 evFOUNDRY The Extracellular Vesicle Foundry 2018
152 ASTHMACRYSTALCLEAR Role of protein crystallization in type 2 immunity and asthma 2018
153 ASSYSt A reliable CXCL4 biomarker assay to improve diagnosis and treatment of Systemic Sclerosis 2018
154 IPUD IPUD – An Implantable Peritoneal Ultrafiltration Device that actively and continuously prevents fluid overload in diuretic resistant heart failure patients. 2018
155 SMR Stroke Management through RGTA®: SMR 2018
156 SECReTE Enhancing biological drug production through protein secretion 2018
157 BIOCARD Deep BIOmodeling of human CARDiogenesis 2018
158 STARNEL supracellular contractility of myofibroblasts in gut homeostasis and cancer invasion 2018
159 ActinSensor Identification and characterization of a novel damage sensor for cytoskeletal proteins in Drosophila 2019
160 INTEGRATA Integrating chemical and biological approaches to target NAD production and signaling in cancer 2018
161 HUMAN TEXTILES Human, Woven, Tissue-Engineered Blood Vessels (TEBV) Exclusively from Cell-Assembled Extracellular Matrix (CAM). 2018
162 BrainNanoFlow Nanoscale dynamics in the extracellular space of the brain in vivo 2018
163 EVERBONE Mechano-activated Extracellular Vesicle Based Repair of Bone 2019
164 CONQR Translation and Commercialization of a QSOX1-inhibitory Antibody Targeting the Tumor Microenvironment in Breast Cancer 2018
165 MNSWLGM An optofluidic platform based on liquid-gradient refractive index microlens for the isolation and quantification of extracellular vesicles 2019
166 EVPRO EVPRO - Development of Extracellular Vesicles loaded hydrogel coatings with immunomodulatory activity for Promoted Regenerative Osseointegration of revision endoprosthesis 2019
167 RESTORE User-centred smart nanobiomaterial-based 3D matrices for chondral repair 2019
168 ESCALON European-Latin American network for the assessment of biomarkers to predict and diagnose hepatobiliary malignancies and characterization of risk factors for cancer development 2019
169 The MATRIX Inflammatory resolution and remodelling of the adipose extracellular matrix: key determinants of a metabolically healthy phenotype? 2019
170 SynECS Combining carbon nanotubes and gold nanorods to investigate the extracellular space around synapses during neuronal communication 2019
171 makingtheretina Principles of retinal neuronal lamination from zebrafish to humans 2019
172 SECRETE-HF SECRETED FACTORS IN CARDIAC REMODELING PROVOKE TUMORIGENESIS AND END ORGAN DAMAGE IN HEART FAILURE 2019
173 PONS Fabrication of Polysaccharides-Protein complex Nano-Hybrid Scaffold as regenerative biomaterial for bone tissue engineering 2019
174 MechanoGenetic Role of mechanical forces in cell-matrix adhesion sites 2019
175 CoVes Communicating Vesicles 2019
176 BrEXo-Apt Non-invasive and accurate diagnosis and treatment of breast cancer. 2019
177 ENGAGE ENGineering extracellular matrix-based de novo proteins with high Affinity to Growth factors for Enhancing bone regeneration 2019
178 MacrophInt Targeting integrin signaling in tumour-associated macrophages to combat cancer progression and resistance 2019
179 EndoPos Endosome positioning in tumour-stroma interactions 2019
180 SNFWD A pH-Responsive Bionanohybrid Nanofibrous Wound Dressing 2019
181 CentrosoTME The role of extra centrosomes on the tumour microenvironment 2019
182 MetaTarGet Targeting metabolic regulation in metastasis formation 2019
183 STRomA Novel Matrix Stiffness-regulated Genes in Lymphangiogenesis and Angiogenesis 2019
184 BiFCCM Bi-directional Force Communication on Cell-Matrix 2019
185 SQSig Oligo-Squaramide Rigid-Rods for Artificial Transmembrane Signaling 2020
186 MINT Multifunctional Immunocompatible NanoTheranostics to modulate tumor microenvironment and improve treatment monitoring: A double blow to pancreatic cancer 2019
187 LactaDiff Assessing cellular compartmentation of brain lactate using diffusion MR spectroscopy in vivo 2019
188 nanoCellSense A nanotechnology-based approach for label-free single-cell analysis of cytoplasmic proteome 2019
189 MIMIC Mapping and modulating integrin mediated interactions 2020
190 signalling dynamics Bridging biophysics and cell biology: The role of G protein-coupled receptor conformations in signalling 2020
191 Recruit Origin and Function of Tumor-Associated Macrophages and Mesenchymal Stromal Cells in GBM Subtypes 2019
192 3DBrainStrom Brain metastases: Deciphering tumor-stroma interactions in three dimensions for the rational design of nanomedicines 2019
193 UNPACK PD-L1 Molecular mechanism and inhibition of extracellular vesicle-mediated PD-L1 release in melanoma cells 2020
194 NanoPSYCH Neuropsychiatric disorders are a heterogeneous group of mental pathologies that demand prolonged and treatments that are frequently ineffective. Elucidating the cellular and molecular mechanisms under 2019
195 PoInt Principles of Integrin Mechanics and Adhesion 2019
196 Nano_Brain Improving drug delivery to the brain and glioblastoma treatment using temperature. 2019
197 TRYPTISSUE Characterising Trypanosoma tissue tropism: new perspectives for variant surface glycoproteins 2019
198 CONNECT-2-CLINIC Pannexin1 nanobodies for the clinical treatment of liver disease 2020
199 IPUD An Implantable Peritoneal Ultrafiltration Device that actively and continuously prevents fluid overload in congestive heart failure patients 2019
200 proEVLifeCycle The life cycle of extracellular vesicles in prostate cancer: from biogenesis and homing, to functional relevance 2019
201 NeutroCure Development of “smart” amplifiers of reactive oxygen species specific to aberrant polymorphonuclear neutrophils for treatment of inflammatory and autoimmune diseases, cancer and myeloablation. 2020
202 TEXAD TEXAD – Tailoring EXosomes for Autoimmune Diseases 2019
203 IN-FET Ionic Neuromodulation For Epilepsy Treatment 2020
204 NOVACHIP Novel vascular-like BBB-on-a-chip 2020
205 CoEvolve Deconstructing and rebuilding the evolution of cell and tissue mechanoadaptation 2020
206 ABODYFORCE High Throughput Microfluidic Cell and Nanoparticle Handling by Molecular and Thermal Gradient Acoustic Focusing 2019
207 EvoMotion Moving around without a brain: Evolution of basal cognition in single-celled organisms 2020
208 AXONENDO Endosomal control of local protein synthesis in axons 2020
209 SYNBIO.ECM SYNBIO.ECM: Designer extracellular matrices to program healthy and diseased cardiac morphogenesis 2020
210 MEPHOS Shaping the Mechano-Pharmacological properties of Microparticles and Extracellular Vesicles for the Treatment of Osteoarthritis 2020
211 AutoCRAT Automated Cellular Robot-Assisted Technologies for translation of discovery-led research in Osteoarthritis 2020
212 ExocyTher Extracellular vesicle production and engineering by turbulence for fistula therapy in thermoreversible hydrogels 2020
213 EVEREST Extracellular Vesicles for Bone Regeneration – alternatives to Stem-cell Therapy 2020
214 VANGUARD New Generation Cell Therapy: Bioartificial Pancreas to Cure Type 1 Diabetes 2020
215 OBSERVE Overcoming cellular barriers to therapeutic RNA delivery using extracellular vesicles 2020
216 NanoBioMade Bioinorganic intracellular synthesis of photo-responsive bio-camouflaged nanomedicines 2021
217 HESSP Hippocampus Extracellular Space Simulator Project (HESSP) 2020
218 MiNeMI Micronnedle-assisted nanovector skin patch for immunomodulation of the inflammatory response upon occurrence of myocardial infarction injury (MiNeMi) 2020
219 ICaRMuSs Intragranullar calcium regulation of mucin secretion and sorting. 2020
220 MRTFSen MRTF/SRF signalling in regulation of cell senescence and melanoma progression 2020
221 CellMechSensE Cell mechanosensing in the extracellular matrix 2020
222 BioPrint4All A 3D-bioprinting platform with exchangeable tailor-made print heads to engineer tissue surrogates 2020