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NeuroN SIGNED

Neurophysiological Biomarkers of Cortical Plasticity Induced by Neuromodulation

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

NeuroN project word cloud

Explore the words cloud of the NeuroN project. It provides you a very rough idea of what is the project "NeuroN" about.

dealing cortical impairment functions influence clinical motor recordings reactivates impaired functional systematic lower patients lack muscle electromyographic generation behavior ankle bci volley neurorehabilitation rehabilitation scales neuron limbs drop interfaces corticospinal survivors therapy spinal therapies hd recovery tests responsible platform moved density techniques induces limb one first effectiveness give device dorsiflexion intriguing drive combination afferent surface motoneurons semg attempt hemiparetic loop tract decomposition restoring brain stroke biomarkers clinicians signals researcher shaping closed plasticity correlates filling command chronic stimulation robot computer coming foot cord function integrating intervention gap nothing excitability neurophysiological deep

Project "NeuroN" data sheet

The following table provides information about the project.

Coordinator	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://sites.google.com/view/h2020-msca-neuron/home
Total cost	159˙461 €
EC max contribution	159˙460 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-10-01 to 2017-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	79˙730.00
2	UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS Organization address address: Robert-Koch-Strasse 40 city: GOETTINGEN postcode: 37075 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (GOETTINGEN)	participant	79˙730.00

Map

Project objective

One of the major issues when dealing with therapies for the rehabilitation of the lower limbs in stroke survivors is the in-deep assessment of their effectiveness and the lack of biomarkers for motor recovery. The motor functionality after therapy is evaluated only through clinical tests and scales which do not give information on the effective muscle state and the changes at the corticospinal level. The aim of restoring the motor functions has moved much of the attention of clinicians and researcher towards the use of the combination of brain stimulation techniques for the assessment of cortical excitability and Brain-Computer Interfaces (BCI) for the control of rehabilitation devices. This intervention induces cortical plasticity and reactivates the closed-loop pathway between the impaired cortical tract and the limb by using the cortical command to drive the device for the generation of the afferent volley. However, nothing is known about the changes of the neurophysiological correlates and how these influence the effective recovery of motor functions. NeuroN represents the first systematic attempt to investigate the neurophysiological correlates of changes in the excitability of the cortical areas responsible for ankle dorsiflexion in chronic hemiparetic stroke survivors with drop foot impairment and to identify novel biomarkers of motor recovery. NeuroN aims at filling the gap of knowledge on the functional effects of increased plasticity in chronic stroke survivors by integrating a BCI robot-based platform with the high-density surface electromyographic (HD-sEMG) recordings. The information coming from the decomposition of HD-sEMG signals give insight into the behavior of the motoneurons in the spinal cord and on the effective control command. NeuroN is expected to address one of the most intriguing issues in the neurorehabilitation field: the novel biomarkers developed will help in shaping new therapies for the recovery of motor function of stroke patients.

Publications

List of publications.
year	authors and title	journal	last update
2016	Francesco Negro, Silvia Muceli, Anna Margherita Castronovo, Ales Holobar, Dario Farina Multi-channel intramuscular and surface EMG decomposition by convolutive blind source separation published pages: 26027, ISSN: 1741-2560, DOI: 10.1088/1741-2560/13/2/026027	Journal of Neural Engineering 13/2	2019-06-18
2017	Dario Farina, Anna Margherita Castronovo, Ivan Vujaklija, Agnes Sturma, Stefan Salminger, Christian Hofer, Oskar Aszmann Common Synaptic Input to Motor Neurons and Neural Drive to Targeted Reinnervated Muscles published pages: 11285-11292, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.1179-17.2017	The Journal of Neuroscience 37/46	2019-06-18
2017	Margherita Castronovo; N. Mrachacz-Kersting; F. Landi; HR. JÃ¸rgensen; K. Severinsen; D. Farina Motor Unit Coherence at Low Frequencies Increases Together with Cortical Excitability Following a Brain-Computer Interface Intervention in Acute Stroke Patients published pages: , ISSN: , DOI: 10.1007/978-3-319-46669-9_162	Converging Clinical and Engineering Research on Neurorehabilitation II/ Biosystems & Biorobotics Vol 15	2019-06-18

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The information about "NEURON" are provided by the European Opendata Portal: CORDIS opendata.