PAINSTRAT SIGNED
Novel neurophysiological techniques to quantify pain and stratify patients
Total Cost €
0EC-Contrib. €
0Partnership
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0PAINSTRAT project word cloud
Explore the words cloud of the PAINSTRAT project. It provides you a very rough idea of what is the project "PAINSTRAT" about.
Project "PAINSTRAT" data sheet
The following table provides information about the project.
| Coordinator |
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Total cost | 1˙627˙825 € |
| EC max contribution | 1˙627˙825 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-01-01 to 2020-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA | IT (GENOVA) | coordinator | 795˙132.00 |
| 2 | UNIVERSITY COLLEGE LONDON | UK (LONDON) | participant | 832˙692.00 |
Map
Project objective
In the last 15 years the advances in understanding the molecular mechanisms of pain have been spectacular. However, despite the >200 genes identified and the dramatic insights on transduction and transmission of nociceptive signals, very little has changed in the diagnosis and treatment of pain, at least in terms of analgesic drugs. Therefore, pain remains a major burden for the society (chronic pain alone costs the EU >€250 bns/yr). The reason is that pain is not a pattern of gene expression, but a state of neuronal activity. Therefore, the translation of mechanistic insights into effective treatments will depend critically on a better understanding of the electrophysiological changes that occur. For this reason, the European Federation of Neurological Society has called for a particular effort to identify reliable laboratory measures of pain, and having an objective biomarker for pain quantification and patient stratification would constitute a major breakthrough in medicine. To date, this need has not been satisfied. The project has two main objectives: (1) Developing neurophysiological biomarkers of pain perception: the main aim being quantification of spontaneous pain for patient management and clinical trials. (2) Developing neurophysiological biomarkers of the susceptibility to develop chronic pain: the main aim being patient stratification, development of prevention strategies, and personalised medicine for pain. We will apply novel analysis techniques to the neurophysiological information obtained using a range of techniques from a large number of healthy volunteers and patients with different types of chronic pain. Importantly, we will longitudinally study patients at high risk of developing chronic pain. We are fully confident that these goals - early diagnosis, identification of high risk patients and facilitating the development of new efficacious treatments through useful clinical trials - will positively impact the well-being of chronic pain patients.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
André Mouraux, Gian Domenico Iannetti The search for pain biomarkers in the human brain published pages: 3290-3307, ISSN: 0006-8950, DOI: 10.1093/brain/awy281 |
Brain 141/12 | 2019-05-20 |
| 2018 |
M. Algoet, J. Duque, G.D. Iannetti, A. Mouraux Temporal Profile and Limb-specificity of Phasic Pain-Evoked Changes in Motor Excitability published pages: 240-255, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2018.06.039 |
Neuroscience 386 | 2019-05-20 |
| 2018 |
Flavia Mancini, Alessia Pepe, Alberto Bernacchia, Giulia Di Stefano, André Mouraux, Gian Domenico Iannetti Characterizing the Short-Term Habituation of Event-Related Evoked Potentials published pages: ENEURO.0014-18.2, ISSN: 2373-2822, DOI: 10.1523/ENEURO.0014-18.2018 |
eneuro 5/5 | 2019-05-20 |
| 2016 |
Li Hu, Gian Domenico Iannetti Painful Issues in Pain Prediction published pages: 212-220, ISSN: 0166-2236, DOI: 10.1016/j.tins.2016.01.004 |
Trends in Neurosciences 39/4 | 2019-05-20 |
| 2017 |
R. J. Bufacchi, C. F. Sambo, G. Di Stefano, G. Cruccu, G. D. Iannetti Pain outside the body: defensive peripersonal space deformation in trigeminal neuralgia published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-12466-5 |
Scientific Reports 7/1 | 2019-05-20 |
| 2018 |
Giacomo Novembre, Vijay M. Pawar, Rory J. Bufacchi, Marina Kilintari, Mandayam Srinivasan, John C. Rothwell, Patrick Haggard, Gian Domenico Iannetti Saliency Detection as a Reactive Process: Unexpected Sensory Events Evoke Corticomuscular Coupling published pages: 2385-2397, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.2474-17.2017 |
The Journal of Neuroscience 38/9 | 2019-05-20 |
| 2018 |
E. R. Ferrè, G. D. Iannetti, J. A. van Dijk, P. Haggard Ineffectiveness of tactile gating shows cortical basis of nociceptive signaling in the Thermal Grill Illusion published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-24635-1 |
Scientific Reports 8/1 | 2019-05-20 |
| 2018 |
Weiwei Peng, Xiaolei Xia, Ming Yi, Gan Huang, Zhiguo Zhang, Giandomenico Iannetti, Li Hu Brain oscillations reflecting pain-related behavior in freely moving rats published pages: 106-118, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000001069 |
PAIN 159/1 | 2019-05-20 |
| 2018 |
Q.Q. Jin, G.Q. Wu, W.W. Peng, X.L. Xia, L. Hu, G.D. Iannetti Somatotopic Representation of Second Pain in the Primary Somatosensory Cortex of Humans and Rodents published pages: 5538-5550, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.3654-17.2018 |
The Journal of Neuroscience 38/24 | 2019-05-20 |
| 2017 |
Karen D. Davis, Herta Flor, Henry T. Greely, Gian Domenico Iannetti, Sean Mackey, Markus Ploner, Amanda Pustilnik, Irene Tracey, Rolf-Detlef Treede, Tor D. Wager Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations published pages: 624-638, ISSN: 1759-4758, DOI: 10.1038/nrneurol.2017.122 |
Nature Reviews Neurology 13/10 | 2019-05-20 |
| 2016 |
Rory John Bufacchi, Gian Domenico Iannetti Gravitational cues modulate the shape of defensive peripersonal space published pages: R1133-R1134, ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.09.025 |
Current Biology 26/21 | 2019-06-07 |
| 2016 |
Flavia Mancini, Karina Dolgevica, James Steckelmacher, Patrick Haggard, Karl Friston, Giandomenico D. Iannetti Perceptual learning to discriminate the intensity and spatial location of nociceptive stimuli published pages: , ISSN: 2045-2322, DOI: 10.1038/srep39104 |
Scientific Reports 6/1 | 2019-06-07 |
| 2016 |
Tim V. Salomons, Gian Domenico Iannetti, Meng Liang, John N. Wood The “Pain Matrix†in Pain-Free Individuals published pages: 755, ISSN: 2168-6149, DOI: 10.1001/jamaneurol.2016.0653 |
JAMA Neurology 73/6 | 2019-06-07 |
| 2016 |
M. Liang, M. C. Lee, J. O\'Neill, A. H. Dickenson, G. D. Iannetti Brain potentials evoked by intraepidermal electrical stimuli reflect the central sensitization of nociceptive pathways published pages: 286-295, ISSN: 0022-3077, DOI: 10.1152/jn.00013.2016 |
Journal of Neurophysiology 116/2 | 2019-06-07 |
| 2016 |
M. Moayedi, G. Di Stefano, M. T. Stubbs, B. Djeugam, M. Liang, G. D. Iannetti Nociceptive-Evoked Potentials Are Sensitive to Behaviorally Relevant Stimulus Displacements in Egocentric Coordinates published pages: , ISSN: 2373-2822, DOI: 10.1523/ENEURO.0151-15.2016 |
eNeuro 3/3 | 2019-06-07 |
| 2016 |
Tor D. Wager, Lauren Y. Atlas, Matthew M. Botvinick, Luke J. Chang, Robert C. Coghill, Karen Deborah Davis, Gian Domenico Iannetti, Russell A. Poldrack, Alexander J. Shackman, Tal Yarkoni Pain in the ACC? published pages: E2474-E2475, ISSN: 0027-8424, DOI: 10.1073/pnas.1600282113 |
Proceedings of the National Academy of Sciences 113/18 | 2019-06-07 |
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