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BetaCellTherapy SIGNED
Beta Cell Generation by Stem Cell-Derived Implants in Diabetes
Total Cost €
0EC-Contrib. €
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0BetaCellTherapy project word cloud
Explore the words cloud of the BetaCellTherapy project. It provides you a very rough idea of what is the project "BetaCellTherapy" about.
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Project "BetaCellTherapy" data sheet
The following table provides information about the project.
| Coordinator |
VRIJE UNIVERSITEIT BRUSSEL
Organization address contact info |
| Coordinator Country | Belgium [BE] |
| Project website | http://www.betacelltherapy.org |
| Total cost | 6˙800˙000 € |
| EC max contribution | 6˙200˙000 € (91%) |
| Programme |
1. H2020-EU.3.1.3. (Treating and managing disease) |
| Code Call | H2020-PHC-2015-single-stage_RTD |
| Funding Scheme | RIA |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-12-01 to 2020-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | VRIJE UNIVERSITEIT BRUSSEL | BE (BRUSSEL) | coordinator | 3˙100˙000.00 |
| 2 | OSPEDALE SAN RAFFAELE SRL | IT (MILANO) | participant | 1˙200˙000.00 |
| 3 | ACADEMISCH ZIEKENHUIS LEIDEN | NL (LEIDEN) | participant | 600˙000.00 |
| 4 | CENTER FOR BETA CELL THERAPY IN DIABETES | BE (BRUSSEL) | participant | 600˙000.00 |
| 5 | VIACYTE, INC CORPORATION | US (SAN DIEGO CA) | participant | 600˙000.00 |
| 6 | INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE | FR (PARIS) | participant | 100˙000.00 |
| 7 | NESTEC SA | CH (LAUSANNE) | participant | 0.00 |
| 8 | NESTEC SA | CH (VEVEY) | participant | 0.00 |
Map
Project objective
Despite improved treatment, diabetes remains a chronic disease with major health risks and heavy burden on patients and society. Serious forms are caused by depletion in pancreatic beta cells and associated loss in insulin’s homeostatic control throughout life. Their cure requires restoration of a metabolically adequate beta cell mass. Implants of beta cell grafts prepared from human pancreases have shown proof-of-principle but also the need for developing a large-scale source for therapeutic cells. Our objective is to generate a functional beta cell mass by stem cell-derived implants in diabetes patients. A combined preclinical and clinical project will search recipient and implant conditions for formation and maturation of beta cells in subcutaneous implants of device-encapsulated pancreatic endodermal cells that are derived from human embryonic stem cells (hu-ES) and manufactured for clinical studies. We collected preclinical evidence for the therapeutic potential of this implant from comparison with clinically used human beta cell grafts. State-of-the art methods and markers have been developed to investigate the biology of implants and to monitor host immune and innate reactivity. This approach helps understand the basis for metabolic outcome and identify targets for improvement. Pilot studies examine the influence of the (auto)immune status of the patients. Data will determine transition to clinical efficacy studies, or indicate the need for further laboratory development. Implants in preclinical models will guide modifications in clinical protocols, and explore the biologic properties of grafts derived from human induced pluripotent stem cell (iPSc) as can also be prepared from diabetes patients. Our consortium joins innovating cells, methods, markers and minds in a unique combination of expert clinical, academic and industry activities that need each other to make progress in an ambitious program.
Deliverables
| Human beta cell grafts with QC data for start transplants in subgroup of type 1 diabetes recipients of VCTM implant | Demonstrators, pilots, prototypes | 2020-03-11 13:03:37 |
| Human beta cell preparations with QC data for comparative assessment of human iPS-derived implants in preclinical model and their use in screening assay | Demonstrators, pilots, prototypes | 2020-03-11 13:03:57 |
| Production of biodegradable microparticles for local release of VEGF, NGF and exenatide | Demonstrators, pilots, prototypes | 2019-09-13 11:09:19 |
| Time-table for public information on program | Other | 2019-09-13 11:09:19 |
| Communication network operational | Other | 2019-09-13 11:09:19 |
Take a look to the deliverables list in detail: detailed list of BetaCellTherapy deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Else M. Balke, Eric V. Balti, Bart Van der Auwera, Ilse Weets, Olivier Costa, Simke Demeester, Pascale Abrams, Kristina Casteels, Marina Coeckelberghs, Sylvie Tenoutasse, Bart Keymeulen, Daniel G. Pipeleers, Frans K. Gorus Accelerated Progression to Type 1 Diabetes in the Presence of HLA-A*24 and -B*18 Is Restricted to Multiple Islet Autoantibody–Positive Individuals With Distinct HLA-DQ and Autoantibody Risk Profiles published pages: 1076-1083, ISSN: 0149-5992, DOI: 10.2337/dc17-2462 |
Diabetes Care 41/5 | 2019-10-29 |
| 2018 |
Silvia Pellegrini, Lorenzo Piemonti, Valeria Sordi Pluripotent stem cell replacement approaches to treat type 1 diabetes published pages: 20-26, ISSN: 1471-4892, DOI: 10.1016/j.coph.2018.07.007 |
Current Opinion in Pharmacology 43 | 2019-10-09 |
| 2018 |
Sarah Roels, Olivier R Costa, Sarah A Tersey, Geert Stangé, Dieter De Smet, Eric V Balti, Pieter Gillard, Bart Keymeulen, Zhidong Ling, Daniel G Pipeleers, Frans K Gorus, Raghavendra G Mirmira, Geert A Martens Combined Analysis of GAD65, miR-375, and Unmethylated Insulin DNA Following Islet Transplantation in Patients With T1D published pages: 451-460, ISSN: 0021-972X, DOI: 10.1210/jc.2017-02520 |
The Journal of Clinical Endocrinology & Metabolism 104/2 | 2019-10-09 |
| 2019 |
Sarah Akbib, Jordy Stichelmans, Geert Stangé, Zhidong Ling, Zerihun Assefa, Karine H. Hellemans Glucocorticoids and checkpoint tyrosine kinase inhibitors stimulate rat pancreatic beta cell proliferation differentially published pages: e0212210, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0212210 |
PLOS ONE 14/2 | 2019-10-09 |
| 2018 |
Olivier R. Costa, Katrijn Verhaeghen, Sarah Roels, Geert Stangé, Zhidong Ling, Daniel Pipeleers, Frans K. Gorus, Geert A. Martens An analytical comparison of three immunoassay platforms for subpicomolar detection of protein biomarker GAD65 published pages: e0193670, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0193670 |
PLOS ONE 13/3 | 2019-10-09 |
| 2018 |
Else M. Balke, Simke Demeester, DaHae Lee, Pieter Gillard, Robert Hilbrands, Ursule Van de Velde, Bart J. Van der Auwera, Zhidong Ling, Bart O. Roep, Daniël G. Pipeleers, Bart Keymeulen, Frans K. Gorus SLC30A8 polymorphism and BMI complement HLA-A*24 as risk factors for poor graft function in islet allograft recipients published pages: 1623-1632, ISSN: 0012-186X, DOI: 10.1007/s00125-018-4609-z |
Diabetologia 61/7 | 2019-10-09 |
| 2015 |
Zhidong Ling, Pieter De Pauw, Daniel Jacobs-Tulleneers-Thevissen, Rui Mao, Pieter Gillard, Christiane S. Hampe, Geert A. Martens, Peter In\'t Veld, Åke Lernmark, Bart Keymeulen, Frans Gorus, Daniel Pipeleers Plasma GAD65, a Marker for Early β-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients published pages: 2314-2321, ISSN: 0021-972X, DOI: 10.1210/jc.2015-1216 |
The Journal of Clinical Endocrinology & Metabolism 100/6 | 2019-10-09 |
| 2018 |
Ines De Mesmaeker, Thomas Robert, Krista G. Suenens, Geert M. Stangé, Freya Van Hulle, Zhidong Ling, Peter Tomme, Daniel Jacobs-Tulleneers-Thevissen, Bart Keymeulen, Daniel G. Pipeleers Increase Functional β-Cell Mass in Subcutaneous Alginate Capsules With Porcine Prenatal Islet Cells but Loss With Human Adult Islet Cells published pages: 2640-2649, ISSN: 0012-1797, DOI: 10.2337/db18-0709 |
Diabetes 67/12 | 2019-10-09 |
| 2015 |
Silvia Pellegrini, Federica Ungaro, Alessia Mercalli, Raffaella Melzi, Guido Sebastiani, Francesco Dotta, Vania Broccoli, Lorenzo Piemonti, Valeria Sordi Human induced pluripotent stem cells differentiate into insulin-producing cells able to engraft in vivo published pages: 1025-1035, ISSN: 0940-5429, DOI: 10.1007/s00592-015-0726-z |
Acta Diabetologica 52/6 | 2019-09-13 |
| 2016 |
Daniel Pipeleers, Thomas Robert, Ines De Mesmaeker, Zhidong Ling Concise Review: Markers for Assessing Human Stem Cell-Derived Implants as β-Cell Replacement in Type 1 Diabetes published pages: 1338-1344, ISSN: 2157-6564, DOI: 10.5966/sctm.2015-0187 |
STEM CELLS Translational Medicine 5/10 | 2019-09-13 |
| 2016 |
Cornelis R. van der Torren, Annemarie A. Verrijn Stuart, DaHae Lee, Jenny Meerding, Ursule van de Velde, Daniel Pipeleers, Pieter Gillard, Bart Keymeulen, Wilco de Jager, Bart O. Roep Serum Cytokines as Biomarkers in Islet Cell Transplantation for Type 1 Diabetes published pages: e0146649, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0146649 |
PLOS ONE 11/1 | 2019-09-13 |
| 2017 |
Cornelis R. van der Torren, Arnaud Zaldumbide, Gaby Duinkerken, Simone H. Brand-Schaaf, Mark Peakman, Geert Stangé, Laura Martinson, Evert Kroon, Eugene P. Brandon, Daniel Pipeleers, Bart O. Roep Immunogenicity of human embryonic stem cell-derived beta cells published pages: 126-133, ISSN: 0012-186X, DOI: 10.1007/s00125-016-4125-y |
Diabetologia 60/1 | 2019-09-13 |
| 2016 |
Annelien Van Dalem, Simke Demeester, Eric V. Balti, Bart Keymeulen, Pieter Gillard, Bruno Lapauw, Christophe De Block, Pascale Abrams, Eric Weber, Ilse Vermeulen, Pieter De Pauw, Daniël Pipeleers, Ilse Weets, Frans K. Gorus Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio published pages: e0166702, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0166702 |
PLOS ONE 11/12 | 2019-09-13 |
| 2017 |
Guido Sebastiani, Marco Valentini, Giuseppina Emanuela Grieco, Giuliana Ventriglia, Laura Nigi, Francesca Mancarella, Silvia Pellegrini, Gianvito Martino, Valeria Sordi, Lorenzo Piemonti, Francesco Dotta MicroRNA expression profiles of human iPSCs differentiation into insulin-producing cells published pages: 265-281, ISSN: 0940-5429, DOI: 10.1007/s00592-016-0955-9 |
Acta Diabetologica 54/3 | 2019-09-13 |
| 2017 |
Maria J L Kracht, Menno van Lummel, Tatjana Nikolic, Antoinette M Joosten, Sandra Laban, Arno R van der Slik, Peter A van Veelen, Françoise Carlotti, Eelco J P de Koning, Rob C Hoeben, Arnaud Zaldumbide, Bart O Roep Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes published pages: 501-507, ISSN: 1078-8956, DOI: 10.1038/nm.4289 |
Nature Medicine 23/4 | 2019-09-13 |
| 2015 |
Gregory L. Szot, Mahesh Yadav, Jiena Lang, Evert Kroon, Justin Kerr, Kuniko Kadoya, Eugene P. Brandon, Emmanuel E. Baetge, Hélène Bour-Jordan, Jeffrey A. Bluestone Tolerance Induction and Reversal of Diabetes in Mice Transplanted with Human Embryonic Stem Cell-Derived Pancreatic Endoderm published pages: 148-157, ISSN: 1934-5909, DOI: 10.1016/j.stem.2014.12.001 |
Cell Stem Cell 16/2 | 2019-09-13 |
| 2015 |
Olivier R. Costa, Geert Stangé, Katrijn Verhaeghen, Benedicte Brackeva, Ellen Nonneman, Christiane S. Hampe, Zhidong Ling, Daniel Pipeleers, Frans K. Gorus, Geert A. Martens Development of an Enhanced Sensitivity Bead-Based Immunoassay for Real-Time In Vivo Detection of Pancreatic β-Cell Death published pages: 4755-4760, ISSN: 0013-7227, DOI: 10.1210/en.2015-1636 |
Endocrinology 156/12 | 2019-09-13 |
| 2017 |
Frans K. Gorus, Eric V. Balti, Anissa Messaaoui, Simke Demeester, Annelien Van Dalem, Olivier Costa, Harry Dorchy, Chantal Mathieu, Luc Van Gaal, Bart Keymeulen, Daniël G. Pipeleers, Ilse Weets Twenty-Year Progression Rate to Clinical Onset According to Autoantibody Profile, Age, and HLA-DQ Genotype in a Registry-Based Group of Children and Adults With a First-Degree Relative With Type 1 Diabetes published pages: 1065-1072, ISSN: 0149-5992, DOI: 10.2337/dc16-2228 |
Diabetes Care 40/8 | 2019-09-13 |
| 2016 |
Zerihun Assefa, Sarah Akbib, Astrid Lavens, Geert Stangé, Zhidong Ling, Karine H. Hellemans, Daniel Pipeleers Direct effect of glucocorticoids on glucose-activated adult rat β-cells increases their cell number and their functional mass for transplantation published pages: E698-E705, ISSN: 0193-1849, DOI: 10.1152/ajpendo.00070.2016 |
American Journal of Physiology - Endocrinology And Metabolism 311/4 | 2019-09-13 |
| 2018 |
Thomas Robert, Ines De Mesmaeker, Geert M. Stangé, Krista G. Suenens, Zhidong Ling, Evert J. Kroon, Daniel G. Pipeleers Functional Beta Cell Mass from Device-Encapsulated hESC-Derived Pancreatic Endoderm Achieving Metabolic Control published pages: 739-750, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.01.040 |
Stem Cell Reports 10/3 | 2019-09-13 |
| 2016 |
Simke Demeester, Else M. Balke, Bart J. Van der Auwera, Pieter Gillard, Robert Hilbrands, DaHae Lee, Ursule Van de Velde, Zhidong Ling, Bart O. Roep, Daniel G. Pipeleers, Frans K. Gorus, Bart Keymeulen HLA-A*24 Carrier Status and Autoantibody Surges Posttransplantation Associate With Poor Functional Outcome in Recipients of an Islet Allograft published pages: 1060-1064, ISSN: 0149-5992, DOI: 10.2337/dc15-2768 |
Diabetes Care 39/6 | 2019-09-13 |
| 2017 |
Annelien Van Dalem, Simke Demeester, Eric V. Balti, Bart Keymeulen, Pieter Gillard, Bruno Lapauw, Christophe De Block, Pascale Abrams, Eric Weber, Ilse Vermeulen, Pieter De Pauw, Daniël Pipeleers, Ilse Weets, Frans K. Gorus Correction: Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio published pages: e0179108, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0179108 |
PLOS ONE 12/6 | 2019-09-13 |
| 2017 |
Elisa Cantarelli, Antonio Citro, Silvia Pellegrini, Alessia Mercalli, Raffaella Melzi, Erica Dugnani, Tatiana Jofra, Georgia Fousteri, Anna Mondino, Lorenzo Piemonti Transplant Site Influences the Immune Response After Islet Transplantation published pages: 1046-1055, ISSN: 0041-1337, DOI: 10.1097/TP.0000000000001462 |
Transplantation 101/5 | 2019-09-13 |
| 2018 |
Silvia Pellegrini, Fabio Manenti, Raniero Chimienti, Rita Nano, Linda Ottoboni, Francesca Ruffini, Gianvito Martino, Philippe Ravassard, Lorenzo Piemonti, Valeria Sordi Differentiation of Sendai Virus-Reprogrammed iPSC into β Cells, Compared with Human Pancreatic Islets and Immortalized β Cell Line published pages: 1548-1560, ISSN: 0963-6897, DOI: 10.1177/0963689718798564 |
Cell Transplantation 27/10 | 2019-09-13 |
| 2017 |
A. Citro, E. Cantarelli, S. Pellegrini, E. Dugnani, L. Piemonti Antiinflammatory strategies in intrahepatic islet transplantation published pages: 1, ISSN: 0041-1337, DOI: 10.1097/TP.0000000000001925 |
Transplantation | 2019-09-13 |
| 2017 |
Daniel Pipeleers, Ines De Mesmaeker, Thomas Robert, Freya Van Hulle Heterogeneity in the Beta-Cell Population: a Guided Search Into Its Significance in Pancreas and in Implants published pages: , ISSN: 1534-4827, DOI: 10.1007/s11892-017-0925-9 |
Current Diabetes Reports 17/10 | 2019-09-13 |
| 2017 |
Valeria Sordi, Silvia Pellegrini, Lorenzo Piemonti Immunological Issues After Stem Cell-Based β Cell Replacement published pages: , ISSN: 1534-4827, DOI: 10.1007/s11892-017-0901-4 |
Current Diabetes Reports 17/9 | 2019-09-13 |
| 2017 |
V. Sordi, S. Pellegrini, M. Krampera, P. Marchetti, A. Pessina, G. Ciardelli, G. Fadini, C. Pintus, G. Pantè, L. Piemonti Stem cells to restore insulin production and cure diabetes published pages: 583-600, ISSN: 0939-4753, DOI: 10.1016/j.numecd.2017.02.004 |
Nutrition, Metabolism and Cardiovascular Diseases 27/7 | 2019-09-13 |
| 2018 |
Monia Cito, Silvia Pellegrini, Lorenzo Piemonti, Valeria Sordi The potential and challenges of alternative sources of β cells for the cure of type 1 diabetes published pages: R114-R125, ISSN: 2049-3614, DOI: 10.1530/EC-18-0012 |
Endocrine Connections 7/3 | 2019-09-13 |
| 2017 |
Dae Hae Lee, Bart Keymeulen, Robert Hilbrands, Zhidong Ling, Ursule Van de Velde, Daniel Jacobs-Tulleneers-Thevissen, Geert Maleux, Bruno Lapauw, Laurent Crenier, Christophe De Block, Chantal Mathieu, Daniel Pipeleers, Pieter Gillard Age and Early Graft Function Relate With Risk-Benefit Ratio of Allogenic Islet Transplantation Under Antithymocyte Globulin-Mycophenolate Mofetil-Tacrolimus Immune Suppression published pages: 2218-2227, ISSN: 0041-1337, DOI: 10.1097/TP.0000000000001543 |
Transplantation 101/9 | 2019-09-13 |
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