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ARREST BLINDNESS SIGNED

Advanced Regenerative and REStorative Therapies to combat corneal BLINDNESS

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

ARREST BLINDNESS project word cloud

Explore the words cloud of the ARREST BLINDNESS project. It provides you a very rough idea of what is the project "ARREST BLINDNESS" about.

therapy therapies artificial quality translating either evaluation lymphatic engineered cycle epithelial compliant cell stages preclinical scarce hindering over restore productivity tissue arrest translation disorders follow cornea regress situations validation blind technologies implant cells gene treatments life supply blood medicine clinic human fabricated millions globally trauma components million collagen visually gmp unnecessarily clinical stem models bio blinding neural image regenerate spectrum organs blindness standardized society regenerative stromal operative endothelial actively additionally monitor stroma vessels postoperative function thinning therapeutic privilege bioengineered proof treatable validate alleviate worldwide scarring tremendous europeans transplantable replace impaired risk transparency lag preparation dystrophy scaffold lack donor scaffolds immune corneal

Project "ARREST BLINDNESS" data sheet

The following table provides information about the project.

Coordinator	LINKOPINGS UNIVERSITET Organization address address: CAMPUS VALLA city: LINKOPING postcode: 581 83 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Project website	http://www.arrestblindness.eu
Total cost	6˙030˙052 €
EC max contribution	5˙993˙177 € (99%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	LINKOPINGS UNIVERSITET LINKOPINGS UNIVERSITET Organization address address: CAMPUS VALLA city: LINKOPING postcode: 581 83 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LINKOPING)	coordinator	1˙623˙175.00
2	KLINIKUM DER UNIVERSITAET ZU KOELN KLINIKUM DER UNIVERSITAET ZU KOELN Organization address address: Kerpener Strasse 62 city: KOELN postcode: 50937 website: www.uk-koeln.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KOELN)	participant	1˙122˙407.00
3	UNIVERSITAIR ZIEKENHUIS ANTWERPEN UNIVERSITAIR ZIEKENHUIS ANTWERPEN Organization address address: WILRIJKSTRAAT 10 city: EDEGEM postcode: 2650 website: www.uza.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (EDEGEM)	participant	738˙065.00
4	NETHERLANDS INSTITUTE FOR INNOVATIVE OCULAR SURGERY NETHERLANDS INSTITUTE FOR INNOVATIVE OCULAR SURGERY Organization address address: LAAN OP ZUID 88 city: ROTTERDAM postcode: 3071AA website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	622˙582.00
5	UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE Organization address address: AVENIDA DE LA UNIVERSIDAD S-N city: ELCHE postcode: 3202 website: www.umh.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (ELCHE)	participant	397˙656.00
6	LINKOCARE LIFE SCIENCES AB LINKOCARE LIFE SCIENCES AB Organization address address: MJARDEVI SCIENCE PARK, TEKNIKRINGEN 10, PLAN 3 city: LINKOPING postcode: 58330 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LINKOPING)	participant	321˙278.00
7	OPTOMEDICAL TECHNOLOGIES GMBH OPTOMEDICAL TECHNOLOGIES GMBH Organization address address: MARIA GOEPPERT STRASSE 9 city: LUBECK postcode: 23562 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LUBECK)	participant	281˙222.00
8	AEON ASTRON EUROPE B.V. AEON ASTRON EUROPE B.V. Organization address address: J.H. OORTWEG 19 city: LEIDEN postcode: 2333 CH website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	277˙075.00
9	AARHUS UNIVERSITET AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AARHUS C)	participant	237˙165.00
10	NOVALIQ GMBH NOVALIQ GMBH Organization address address: IM NEUENHEIMER FELD 515 city: HEIDELBERG postcode: 69120 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	149˙250.00
11	LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG Organization address address: NUSSDORFER STRASSE 64/6 city: WIEN postcode: 1090 website: http://www.lbitrauma.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	142˙800.00
12	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	80˙500.00
13	GENE SIGNAL INTERNATIONAL SA GENE SIGNAL INTERNATIONAL SA Organization address address: PARC SCIENTIFIQUE EPFL - PSE A city: LAUSANNE postcode: 1015 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	0.00

Map

Project objective

Over 30 million Europeans are blind or visually impaired, leading to reduced quality of life and a tremendous loss of productivity in society. Corneal blindness is the second largest cause of blindness globally and while treatable, millions remain unnecessarily blind due to issues of access to transplantable tissue, lack of standardized treatments, and the lag in translating new regenerative medicine therapies to the clinic. The objective of ARREST BLINDNESS is therefore to develop and validate new regenerative-based therapies addressing a spectrum of blinding disorders of the cornea. These conditions either have no effective current treatments, depend on a scarce supply of donor tissue, or non-standardized methods are hindering validation of promising regenerative treatments. To achieve our objective, we will implant GMP-fabricated collagen-based bioengineered scaffolds to replace or regenerate the corneal stroma in cases of stromal thinning, scarring, dystrophy or trauma; deliver therapeutic epithelial stem and endothelial cells to the cornea to restore its transparency; deliver regenerative factors to promote neural growth and function; and actively maintain corneal immune privilege in high-risk situations by targeted therapeutic approaches to regress blood and lymphatic vessels. We will additionally develop advanced methods to image and monitor therapy throughout the cycle from GMP-compliant cell and scaffold preparation through the pre- and intra-operative stages, to postoperative follow-up and evaluation. After proof-of-concept and preclinical validation of key enabling components, these technologies will be used by one or several partners in preclinical models and in phase I/II human clinical studies. ARREST BLINDNESS directly addresses the translation of regenerative medicine, bio-artificial organs, tissue engineered scaffolds, and advanced cell and gene therapies into clinical use and will help to alleviate the worldwide problem of corneal blindness.

Deliverables

List of deliverables.
First study approvals package for Phase I Biocornea study	Documents, reports	2020-01-29 12:55:43
Classification of LSCD by in vivo confocal microscopy	Documents, reports	2020-01-29 12:55:43
Final report on minipig study results	Documents, reports	2020-01-29 12:55:43
Project website and promotional materials	Websites, patent fillings, videos etc.	2020-01-29 12:55:43
Dissemination and Exploitation Strategy	Websites, patent fillings, videos etc.	2020-01-29 12:55:43
All approvals package for multicenter Phase II study	Documents, reports	2020-01-29 12:55:43

Take a look to the deliverables list in detail: detailed list of ARREST BLINDNESS deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Federico Bech, Omar GonzÃ¡lez-GonzÃ¡lez, Enol Artime, Joana Serrano, Ignacio Alcalde, Juana Gallar, JesÃºs Merayo-Lloves, Carlos Belmonte Functional and Morphologic Alterations in Mechanical, Polymodal, and Cold Sensory Nerve Fibers of the Cornea Following Photorefractive Keratectomy published pages: 2281, ISSN: 1552-5783, DOI: 10.1167/iovs.18-24007	Investigative Opthalmology & Visual Science 59/6	2020-01-29
2018	Viet Nhat Hung Le, Ann-Charlott Schneider, Rebecca Scholz, Felix Bock, Claus Cursiefen Fine Needle-Diathermy Regresses Pathological Corneal (Lymph)Angiogenesis and Promotes High-Risk Corneal Transplant Survival published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-24037-3	Scientific Reports 8/1	2020-01-29
2018	Yanhong Hou, Viet Nhat Hung Le, GÃ¡bor TÃ³th, Sebastian Siebelmann, Jens Horstmann, Tim Gabriel, Felix Bock, Claus Cursiefen UV light crosslinking regresses mature corneal blood and lymphatic vessels and promotes subsequent high-risk corneal transplant survival published pages: 2873-2884, ISSN: 1600-6135, DOI: 10.1111/ajt.14874	American Journal of Transplantation 18/12	2020-01-29
2018	Daniele Spinozzi, Alina Miron, Marieke Bruinsma, Isabel Dapena, Itay Lavy, Perry S. Binder, Mehrdad Rafat, Silke Oellerich, Gerrit R.J. Melles Evaluation of the Suitability of Biocompatible Carriers as Artificial Transplants Using Cultured Porcine Corneal Endothelial Cells published pages: 1-7, ISSN: 0271-3683, DOI: 10.1080/02713683.2018.1536215	Current Eye Research	2020-01-29
2018	Sebastian Siebelmann, Paula Scholz, Simon Sonnenschein, BjÃ¶rn Bachmann, Mario Matthaei, Claus Cursiefen, Ludwig M. Heindl Anterior segment optical coherence tomography for the diagnosis of corneal dystrophies according to the IC3D classification published pages: 365-380, ISSN: 0039-6257, DOI: 10.1016/j.survophthal.2017.08.001	Survey of Ophthalmology 63/3	2020-01-29
2018	Viet Nhat Hung Le, Yanhong Hou, Jens Horstmann, Felix Bock, Claus Cursiefen Novel Method to Detect Corneal Lymphatic Vessels In Vivo by Intrastromal Injection of Fluorescein published pages: 267-271, ISSN: 0277-3740, DOI: 10.1097/ico.0000000000001444	Cornea 37/2	2020-01-29
2017	Jens Horstmann, Hinnerk Schulz-Hildebrandt, Felix Bock, Sebastian Siebelmann, Eva Lankenau, Gereon HÃ¼ttmann, Philipp Steven, Claus Cursiefen Label-Free In Vivo Imaging of Corneal Lymphatic Vessels Using Microscopic Optical Coherence Tomography published pages: 5880, ISSN: 1552-5783, DOI: 10.1167/iovs.17-22286	Investigative Opthalmology & Visual Science 58/13	2020-01-29
2018	M. Notara, S. Behboudifard, M. A. Kluth, C. MaÃŸlo, C. Ganss, M. H. Frank, B. Schumacher, C. Cursiefen UV light-blocking contact lenses protect against short-term UVB-induced limbal stem cell niche damage and inflammation published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-30021-8	Scientific Reports 8/1	2020-01-29

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The information about "ARREST BLINDNESS" are provided by the European Opendata Portal: CORDIS opendata.

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