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MICROBRADAM SIGNED

Advanced MR methods for characterization of microstructural brain damage

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MICROBRADAM" data sheet

The following table provides information about the project.

Coordinator
MUSEO STORICO DELLA FISICA E CENTRO STUDI E RICERCHE ENRICO FERMI 

Organization address
address: VIA PANISPERNA 89/A
city: ROMA
postcode: 184
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://microbradam.marbilab.eu
 Total cost 540˙000 €
 EC max contribution 540˙000 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2015
 Funding Scheme MSCA-RISE
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2019-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MUSEO STORICO DELLA FISICA E CENTRO STUDI E RICERCHE ENRICO FERMI IT (ROMA) coordinator 162˙000.00
2    FAKULTNI NEMOCNICE U SV. ANNY V BRNE CZ (Brno) participant 90˙000.00
3    ITA-SUOMEN YLIOPISTO FI (KUOPIO) participant 90˙000.00
4    Masarykova univerzita CZ (BRNO STRED) participant 90˙000.00
5    CHARLES RIVER DISCOVERY RESEARCH SERVICES FINLAND OY FI (KUOPIO) participant 54˙000.00
6    UNIVERSITA DEGLI STUDI DI SALERNO IT (FISCIANO SA) participant 54˙000.00
7    REGENTS OF UNIVERSITY OF MINNESOTA US (MINNEAPOLIS MN) partner 0.00

Map

 Project objective

NMR (Nuclear Magnetic Resonance)-based approaches have affirmed as extremely valuable for applications in neurosciences. Nonetheless, the exquisite flexibility of tissue contrast in magnetic resonance imaging (MRI) that can be obtained by proper manipulation of nuclear spins still offers room for technological improvements which can be quickly expanded to clinical routine. In particular, there is extreme need of imaging methods that allow a correct assessment of microstructural damage in many brain diseases, including – but not limited to – neurodegenerative diseases. Indeed, current MRI techniques suffer from poor specificity and ultimately lack the ability to identify the microscopic biophysical and biological mechanisms related to the specific features of the pathology. This project aims at expanding the set of MR based techniques available to neuroscientists to characterize microstructural damage, assessing the usefulness of these approaches in some specific pathologies where they offer more promise. Notably, this project aims also at establishing the increased specificity and sensitivity of newly developed and current techniques when merged in a truly multiparametric analysis approach. This project is heavily based on networking activities for exchanging the complimentary knowledge available at the different world-class academic and commercial EU and third country sites. The novel MRI pulse sequences and data analyses approaches tested and validated during the course of the project will be available at each site of the consortium, and will be made available to the scientific community as well.

 Deliverables

List of deliverables.
Press conferences Other 2020-02-07 15:38:57
Scientific workshops Other 2020-02-07 15:39:02
“Doors open” Other 2019-06-06 16:13:50
Human dataset complete, final report Other 2019-06-06 16:13:46
Scientific publications on MRI development/application on humans Documents, reports 2019-05-09 09:30:39
Web site released Websites, patent fillings, videos etc. 2019-05-16 12:44:27
Scientific publications on MRI development/application on animals Documents, reports 2019-05-16 12:44:28

Take a look to the deliverables list in detail:  detailed list of MICROBRADAM deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Pavel Filip, Pavla Linhartová, Pavlína Hlavatá, Rastislav Šumec, Marek Baláž, Martin Bareš, Tomáš Kašpárek
Disruption of Multiple Distinctive Neural Networks Associated With Impulse Control Disorder in Parkinson\'s Disease
published pages: , ISSN: 1662-5161, DOI: 10.3389/fnhum.2018.00462
Frontiers in Human Neuroscience 12 2020-02-27
2020 Pavlína Hlavatá, Pavla Linhartová, Rastislav Šumec, Pavel Filip, Miroslav Světlák, Marek Baláž, Tomáš Kašpárek, Martin Bareš
Behavioral and Neuroanatomical Account of Impulsivity in Parkinson\'s Disease
published pages: , ISSN: 1664-2295, DOI: 10.3389/fneur.2019.01338
Frontiers in Neurology 10 2020-02-27
2020 Michela Fratini, Ali Abdollahzadeh, Mauro DiNuzzo, Raimo A. Salo, Laura Maugeri, Alessia Cedola, Federico Giove, Olli Gröhn, Jussi Tohka, Alejandra Sierra
Multiscale Imaging Approach for Studying the Central Nervous System: Methodology and Perspective
published pages: 72, ISSN: 1662-453X, DOI: 10.3389/fnins.2020.00072
Frontiers in Neuroscience 14 2020-02-13
2018 Timo Liimatainen, Hanne Laakso, Djaudat Idiyatullin, Silvia Mangia, Shalom Michaeli
Capturing exchange using periodic radiofrequency irradiation
published pages: 79-84, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2018.09.001
Journal of Magnetic Resonance 296 2019-11-11
2018 E. Stefanutti, A. Sierra, P. Miocchi, L. Massimi, F. Brun, L. Maugeri, I. Bukreeva, A. Nurmi, G. Begani Provinciali, G. Tromba, O. Gröhn, F. Giove, A. Cedola, M. Fratini
Assessment of the effects of different sample perfusion procedures on phase-contrast tomographic images of mouse spinal cord
published pages: C03027-C03027, ISSN: 1748-0221, DOI: 10.1088/1748-0221/13/03/C03027
Journal of Instrumentation 13/03 2019-05-09
2018 Silvia Tommasin, Daniele Mascali, Marta Moraschi, Tommaso Gili, Ibrahim Eid Hassan, Michela Fratini, Mauro DiNuzzo, Richard G. Wise, Silvia Mangia, Emiliano Macaluso, Federico Giove
Scale-invariant rearrangement of resting state networks in the human brain under sustained stimulation
published pages: 570-581, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2018.06.006
NeuroImage 179 2019-05-09
2018 Silvia Mangia, Alena Svatkova, Daniele Mascali, Mikko J. Nissi, Philip C. Burton, Petr Bednarik, Edward J. Auerbach, Federico Giove, Lynn E. Eberly, Michael J. Howell, Igor Nestrasil, Paul J. Tuite, Shalom Michaeli
Corrigendum: Multi-modal Brain MRI in Subjects with PD and iRBD
published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2018.00446
Frontiers in Neuroscience 12 2019-05-09
2017 Lauri J. Lehto, Djaudat Idiyatullin, Jinjin Zhang, Lynn Utecht, Gregor Adriany, Michael Garwood, Olli Gröhn, Shalom Michaeli, Silvia Mangia
MB-SWIFT functional MRI during deep brain stimulation in rats
published pages: 443-448, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.08.012
NeuroImage 159 2019-06-17
2017 Silvia Mangia, Alena Svatkova, Daniele Mascali, Mikko J. Nissi, Philip C. Burton, Petr Bednarik, Edward J. Auerbach, Federico Giove, Lynn E. Eberly, Michael J. Howell, Igor Nestrasil, Paul J. Tuite, Shalom Michaeli
Multi-modal Brain MRI in Subjects with PD and iRBD
published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2017.00709
Frontiers in Neuroscience 11 2019-06-17
2018 Daniele Mascali, Mauro DiNuzzo, Laura Serra, Silvia Mangia, Bruno Maraviglia, Marco Bozzali, Federico Giove
Disruption of Semantic Network in Mild Alzheimer’s Disease Revealed by Resting-State fMRI
published pages: 38-48, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2017.11.030
Neuroscience 371 2019-06-17
2017 Lauri J Lehto, Julia P Slopsema, Matthew D Johnson, Artem Shatillo, Benjamin A Teplitzky, Lynn Utecht, Gregor Adriany, Silvia Mangia, Alejandra Sierra, Walter C Low, Olli Gröhn, Shalom Michaeli
Orientation selective deep brain stimulation
published pages: 16016, ISSN: 1741-2560, DOI: 10.1088/1741-2552/aa5238
Journal of Neural Engineering 14/1 2019-06-17
2017 Silvia Tommasin, Daniele Mascali, Tommaso Gili, Ibrahim Eid Assan, Marta Moraschi, Michela Fratini, Richard G. Wise, Emiliano Macaluso, Silvia Mangia, Federico Giove
Task-Related Modulations of BOLD Low-Frequency Fluctuations within the Default Mode Network
published pages: , ISSN: 2296-424X, DOI: 10.3389/fphy.2017.00031
Frontiers in Physics 5 2019-06-17
2017 Mauro DiNuzzo, Daniele Mascali, Marta Moraschi, Giorgia Bussu, Bruno Maraviglia, Silvia Mangia, Federico Giove
Temporal Information Entropy of the Blood-Oxygenation Level-Dependent Signals Increases in the Activated Human Primary Visual Cortex
published pages: , ISSN: 2296-424X, DOI: 10.3389/fphy.2017.00007
Frontiers in Physics 5 2019-06-17
2018 Ivan Rektor, Alena Svátková, Lubomir Vojtíšek, Iva Zikmundová, Jirí Vaníček, András Király, Nikoletta Szabó
White matter alterations in Parkinson’s disease with normal cognition precede grey matter atrophy
published pages: e0187939, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0187939
PLOS ONE 13/1 2019-06-17
2017 Lauri J. Lehto, Aloma A. Albors, Alejandra Sierra, Laura Tolppanen, Lynn E. Eberly, Silvia Mangia, Antti Nurmi, Shalom Michaeli, Olli Gröhn
Lysophosphatidyl Choline Induced Demyelination in Rat Probed by Relaxation along a Fictitious Field in High Rank Rotating Frame
published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2017.00433
Frontiers in Neuroscience 11 2019-06-17

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