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BD2Decide SIGNED

Big Data and models for personalized Head and Neck Cancer Decision support

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BD2Decide project word cloud

Explore the words cloud of the BD2Decide project. It provides you a very rough idea of what is the project "BD2Decide" about.

inadequate fact quality 150 lymph patients therapy tailor virtuous decision die imaging functionalities realizes nodes heterogeneity abuse dss care techniques cancers mortality participation circle maximizes uncover majority worldwide 6th contrast bd2decide detected learning data patient graphical aesthetics few risk links tumors hnc multiscale population stage head intrinsic pathology tools clinical toxicity morbidity biomolecular visualization therapeutic first multicentric diagnosed clinicians epidemiology precise fits deadly hpv neck minimizes hard disclosure validates life models treatment impacts line usual capture 70 severe create treatments size alcohol tumor provides co big metastasis validate prognostic deteriorate tnm patterns prediction behavioral implementing region smoking genomic

Project "BD2Decide" data sheet

The following table provides information about the project.

Coordinator	AZIENDA OSPEDALIERO-UNIVERSITARIA DI PARMA Organization address address: VIA GRAMSCI 14 city: PARMA postcode: 43100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.bd2decide.eu/
Total cost	4˙845˙000 €
EC max contribution	4˙845˙000 € (100%)
Programme	1. H2020-EU.3.1.5. (Methods and data)
Code Call	H2020-PHC-2015-single-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AZIENDA OSPEDALIERO-UNIVERSITARIA DI PARMA AZIENDA OSPEDALIERO-UNIVERSITARIA DI PARMA Organization address address: VIA GRAMSCI 14 city: PARMA postcode: 43100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PARMA)	coordinator	464˙375.00
2	FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI Organization address address: Via Venezian 1 city: Milan postcode: 20133 website: www.istitutotumori.mi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (Milan)	participant	815˙000.00
3	STICHTING VUMC STICHTING VUMC Organization address address: DE BOELELAAN 1117 city: AMSTERDAM postcode: 1081 HV website: www.vumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	760˙937.00
4	ALL-IN-IMAGE LTD ALL-IN-IMAGE LTD Organization address address: MASKIT 32 city: HERTZELIA postcode: 46733 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (HERTZELIA)	participant	495˙750.00
5	UNIVERSIDAD POLITECNICA DE MADRID UNIVERSIDAD POLITECNICA DE MADRID Organization address address: CALLE RAMIRO DE MAEZTU 7 EDIFICIO RECTORADO city: MADRID postcode: 28040 website: www.upm.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	415˙000.00
6	STICHTING MAASTRICHT RADIATION ONCOLOGY MAASTRO CLINIC STICHTING MAASTRICHT RADIATION ONCOLOGY MAASTRO CLINIC Organization address address: Dr. Tanslaan 12 city: MAASTRICHT postcode: 6229 ET website: www.maastro.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	373˙062.00
7	ATHENS TECHNOLOGY CENTER ANONYMI BIOMICHANIKI EMPORIKI KAI TECHNIKI ETAIREIA EFARMOGON YPSILIS TECHNOLOGIAS ATHENS TECHNOLOGY CENTER ANONYMI BIOMICHANIKI EMPORIKI KAI TECHNIKI ETAIREIA EFARMOGON YPSILIS TECHNOLOGIAS Organization address address: RIZAREIOU 10 city: ATHINA postcode: 152 33 website: www.atc.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	participant	342˙000.00
8	HEINRICH-HEINE-UNIVERSITAET DUESSELDORF HEINRICH-HEINE-UNIVERSITAET DUESSELDORF Organization address address: UNIVERSITAETSSTRASSE 1 city: DUSSELDORF postcode: 40225 website: www.uni-duesseldorf.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DUSSELDORF)	participant	338˙750.00
9	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	321˙375.00
10	POLITECNICO DI MILANO POLITECNICO DI MILANO Organization address address: PIAZZA LEONARDO DA VINCI 32 city: MILANO postcode: 20133 website: www.polimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	308˙750.00
11	MULTIMED ENGINEERS SRL MULTIMED ENGINEERS SRL Organization address address: STRADA FELICE CAVALLOTTI 11 city: PARMA postcode: 43121 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PARMA)	participant	150˙000.00
12	UNIVERSITA DEGLI STUDI DI PARMA UNIVERSITA DEGLI STUDI DI PARMA Organization address address: VIA UNIVERSITA 12 city: PARMA postcode: 43100 website: www.unipr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PARMA)	participant	60˙000.00
13	STICHTING VU STICHTING VU Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV website: www.vu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	0.00

Map

Project objective

'Cancers of the Head and Neck Region (HNC) are the 6th more deadly cancers worldwide: in Europe ~150.000 new cases are detected and ~70.000 patients die every year. The main reasons for high mortality are the fact that the majority of cases are diagnosed in advanced Stage and the intrinsic heterogeneity of such tumors. At present the only adopted treatment decision method is based on TNM (Tumor-lymph-Nodes-Metastasis) prognostic system, that considers only a few risk factors such as smoking, alcohol abuse and more recently HPV. The TNM system is therefore inadequate to capture the patient-specific biomolecular characteristics of the tumor. HNC treatments can have hard impact on patient’s aesthetics and functionalities and, due to their toxicity, can cause severe morbidity and greatly deteriorate patient’s quality of life. A more precise prognostic prediction than the current TNM system is needed that allows implementing the first-line treatment that maximizes the therapeutic result and minimizes the impacts of therapy. BD2Decide DSS provides clinicians with the 'means' and all the necessary information to tailor treatment and care delivery pathway to each and any HNC patient during their usual practice, in contrast to current “one-size-fits-all approach”. BD2Decide realizes and validates an Integrated Decision Support System that links population-specific epidemiology and behavioral data, patient-specific genomic, pathology, clinical and imaging data with big data techniques, multiscale prognostic models. Advanced graphical visualization tools are developed for prognostic data disclosure and patient co-participation to the selected treatment. BD2Decide will improve the clinical decision process, uncover new patient-specific patterns that can improve care, and create a virtuous circle of learning. A multicentric clinical study with more than 1.000 patients will be used to validate the system. '

Deliverables

List of deliverables.
Cost-utility analysis tool	Other	2020-02-07 15:51:59
Technology validation report	Documents, reports	2020-02-07 15:51:53
Impacts assessment	Documents, reports	2020-02-07 15:51:59
The IPDA prototype	Other	2019-05-30 14:12:51
The BD2Decide visualization mock-ups concepts	Demonstrators, pilots, prototypes	2019-05-30 14:12:48
Dissemination materials - second release	Demonstrators, pilots, prototypes	2019-05-30 14:12:48
Quality Plan and Risk assessment	Documents, reports	2019-05-30 14:12:44
Dissemination materials - first release	Demonstrators, pilots, prototypes	2019-05-30 14:12:45
Communications plan and strategy - second release	Documents, reports	2019-05-30 14:12:43
User interaction sketches	Demonstrators, pilots, prototypes	2019-05-30 14:12:43
Collected population data	Documents, reports	2019-05-30 14:12:43
Multilayer data acquisition and management services	Other	2019-05-30 14:12:48
Communication plan and strategy	Documents, reports	2019-05-30 14:12:39
Project web site	Websites, patent fillings, videos etc.	2019-05-30 14:12:49
User needs and use cases	Documents, reports	2019-05-30 14:12:46
Tumor & Lymph-nodes segmentation features	Documents, reports	2019-05-30 14:12:42
Ethics report	Documents, reports	2019-05-30 14:12:51
System architecture	Documents, reports	2019-05-30 14:12:50
The Visual Analytics tool	Other	2019-05-09 18:04:11
The Clinical DSS tool suite	Other	2019-05-09 18:04:11
The BD2Decide visualization mock-ups	Demonstrators, pilots, prototypes	2019-05-09 18:04:11
Communication plan and strategy - final edition	Documents, reports	2019-05-09 18:04:11
Knowledge Management System	Other	2019-05-09 18:04:11
Usability Evaluation results	Documents, reports	2019-05-09 18:04:11
Dissemination materials - third release	Demonstrators, pilots, prototypes	2019-05-09 18:04:11
Security and Standards for Clinical data	Documents, reports	2019-05-09 18:04:11

Take a look to the deliverables list in detail: detailed list of BD2Decide deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Marco Bologna, Valentina Corino, Luca Mainardi Technical Note: Virtual phantom analyses for preprocessing evaluation and detection of a robust feature set for MRIâ€radiomics of the brain published pages: , ISSN: 0094-2405, DOI: 10.1002/mp.13834	Medical Physics	2019-10-15
2017	Giuseppe Fico Big Data for Head & Neck Cancer (Workshop on BIG DATA TO IMPROVE OUTCOMES, PROCESS AND SERVICES IN HEALTH) published pages: , ISSN: , DOI:	39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society	2019-06-17
2017	Kathrin Scheckenbach, Lena Colter, Martin Wagenmann Radiomics in Head and Neck Cancer: Extracting Valuable Information from Data beyond Recognition published pages: 65-71, ISSN: 0301-1569, DOI: 10.1159/000455704	ORL 79/1-2	2019-06-17
2017	Luca Tonella, Marco Giannoccaro, Salvatore Alfieri, Silvana Canevari, Loris De Cecco Gene Expression Signatures for Head and Neck Cancer Patient Stratification: Are Results Ready for Clinical Application? published pages: , ISSN: 1527-2729, DOI: 10.1007/s11864-017-0472-2	Current Treatment Options in Oncology 18/5	2019-06-17
2017	Valentina D.A. Corino, Eros Montin, Antonella Messina, Paolo G. Casali, Alessandro Gronchi, Alfonso MarchianÃ², Luca T. Mainardi Radiomic analysis of soft tissues sarcomas can distinguish intermediate from high-grade lesions published pages: , ISSN: 1053-1807, DOI: 10.1002/jmri.25791	Journal of Magnetic Resonance Imaging	2019-06-17
2017	Janna E. van Timmeren, Ralph T. H. Leijenaar, Wouter van Elmpt, Bart Reymen, Philippe Lambin Feature selection methodology for longitudinal cone-beam CT radiomics published pages: 1537-1543, ISSN: 0284-186X, DOI: 10.1080/0284186x.2017.1350285	Acta Oncologica 56/11	2019-06-17
2017	Dan Ou, Pierre Blanchard, Silvia Rosellini, Antonin Levy, France Nguyen, Ralph T.H. Leijenaar, Ingrid Garberis, Philippe Gorphe, FranÃ§ois Bidault, Charles FertÃ©, Charlotte Robert, Odile Casiraghi, Jean-Yves Scoazec, Philippe Lambin, Stephane Temam, Eric Deutsch, Yungan Tao Predictive and prognostic value of CT based radiomics signature in locally advanced head and neck cancers patients treated with concurrent chemoradiotherapy or bioradiotherapy and its added value to Human Papillomavirus status published pages: 150-155, ISSN: 1368-8375, DOI: 10.1016/j.oraloncology.2017.06.015	Oral Oncology 71	2019-06-17
2017	Paolo Bossi, Marco Siano, Cristiana Bergamini, Maria Cossu Rocca, Andrea P. Sponghini, Marco Giannoccaro, Luca Tonella, Alessandro Paoli, Edoardo Marchesi, Federica Perrone, Silvana Pilotti, Laura D. Locati, Silvana Canevari, Lisa Licitra, Loris De Cecco Are Fusion Transcripts in Relapsed/Metastatic Head and Neck Cancer Patients Predictive of Response to Anti-EGFR Therapies? published pages: 1-9, ISSN: 0278-0240, DOI: 10.1155/2017/6870614	Disease Markers 2017	2019-06-17
2017	Aniek J.G. Even, Olga Hamming-Vrieze, Wouter van Elmpt, VÃ©ronique J.L. Winnepenninckx, Jolien Heukelom, Margot E.T. Tesselaar, Wouter V. Vogel, Ann Hoeben, Catharina M.L. Zegers, DaniÃ«lle J. Vugts, Guus A.M.S. van Dongen, Harry Bartelink, Felix M. Mottaghy, Frank Hoebers, Philippe Lambin Quantitative assessment of Zirconium-89 labeled cetuximab using PET/CT imaging in patients with advanced head and neck cancer: a theragnostic approach published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.13910	Oncotarget	2019-06-17
2017	Laura Lopez Perez, Liss Hernandez, Giuseppe Fico, and Maria Teresa Arredondo Definition of a Decision Support System to Support Research on Head and Neck Cancer published pages: , ISSN: , DOI:	39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Korea, July 2017	2019-06-17
2018	Marco Bologna, Valentina D. A. Corino, Eros Montin, Antonella Messina, Giuseppina Calareso, Francesca G. Greco, Silvana Sdao, Luca T. Mainardi Assessment of Stability and Discrimination Capacity of Radiomic Features on Apparent Diffusion Coefficient Images published pages: 879-894, ISSN: 0897-1889, DOI: 10.1007/s10278-018-0092-9	Journal of Digital Imaging 31/6	2019-05-09
2018	Sebastian Sanduleanu, Henry C. Woodruff, Evelyn E.C. de Jong, Janna E. van Timmeren, Arthur Jochems, Ludwig Dubois, Philippe Lambin Tracking tumor biology with radiomics: A systematic review utilizing a radiomics quality score published pages: 349-360, ISSN: 0167-8140, DOI: 10.1016/j.radonc.2018.03.033	Radiotherapy and Oncology 127/3	2019-05-09
2018	Alberto Vazquez, Liss Hernandez, Laura Lopez-Perez, Ana Ugena, Sergio Guillen, Maria T. Arredondo and Giuseppe Fico, Member Integration of Radiomics Information in a Computerized Decision Support System for Research on Head and Neck Cancer. In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. published pages: , ISSN: , DOI:	40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Annually	2019-05-09
2018	Hernandez, L., Lopez-Perez, L., Fico, G., FernÃ¡ndez, A., Ugena, A., GuillÃ©n, S., Cabrera, M. F., Arredondo, M. T. A computerized decision support system for head and neck cancer. In IEEE Conference on Biomedical and Health Informatics. published pages: , ISSN: , DOI:	IEEE Conference on Biomedical and Health Informatics Annually	2019-05-09
2018	Kathrin Scheckenbach Radiomics: Big Data statt Biopsie in der Zukunft? published pages: S114-S141, ISSN: 0935-8943, DOI: 10.1055/s-0043-121964	Laryngo-Rhino-Otologie 97/S 01	2019-05-09
2017	Bogowicz M, Leijenaar RTH, Tanadini-Lang S, Riesterer O, Pruschy M, Studer G, Unkelbach J, Guckenberger M, Konukoglu E, Lambin P. Post-radiochemotherapy PET radiomics in head and neck cancer - The influence of radiomics implementation on the reproducibility of local control tumor models published pages: 385-391, ISSN: 0167-8140, DOI:	Radiother Oncol.	2019-05-09
2018	Timo M. Deist, Frank J. W. M. Dankers, Gilmer Valdes, Robin Wijsman, I-Chow Hsu, Cary Oberije, Tim Lustberg, Johan van Soest, Frank Hoebers, Arthur Jochems, Issam El Naqa, Leonard Wee, Olivier Morin, David R. Raleigh, Wouter Bots, Johannes H. Kaanders, JosÃ© Belderbos, Margriet Kwint, Timothy Solberg, RenÃ© Monshouwer, Johan Bussink, Andre Dekker, Philippe Lambin Machine learning algorithms for outcome prediction in (chemo)radiotherapy: An empirical comparison of classifiers published pages: 3449-3459, ISSN: 0094-2405, DOI: 10.1002/mp.12967	Medical Physics 45/7	2019-05-09
2018	Ruben T. H. M. Larue, Remy Klaassen, Arthur Jochems, Ralph T. H. Leijenaar, Maarten C. C. M. Hulshof, Mark I. van Berge Henegouwen, Wendy M. J. Schreurs, Meindert N. Sosef, Wouter van Elmpt, Hanneke W. M. van Laarhoven, Philippe Lambin Pre-treatment CT radiomics to predict 3-year overall survival following chemoradiotherapy of esophageal cancer published pages: 1475-1481, ISSN: 0284-186X, DOI: 10.1080/0284186X.2018.1486039	Acta Oncologica 57/11	2019-05-09
2018	Ralph TH Leijenaar, Marta Bogowicz, Arthur Jochems, Frank JP Hoebers, Frederik WR Wesseling, Sophie H Huang, Biu Chan, John N Waldron, Brian O\'Sullivan, Derek Rietveld, C Rene Leemans, Ruud H Brakenhoff, Oliver Riesterer, Stephanie Tanadini-Lang, Matthias Guckenberger, Kristian Ikenberg, Philippe Lambin Development and validation of a radiomic signature to predict HPV (p16) status from standard CT imaging: a multicenter study published pages: 20170498, ISSN: 0007-1285, DOI: 10.1259/bjr.20170498	The British Journal of Radiology 2018 Jun;91(1086)	2019-05-09
2017	Dennis E. te Beest, Steven W. Mes, Saskia M. Wilting, Ruud H. Brakenhoff, Mark A. van de Wiel Improved high-dimensional prediction with Random Forests by the use of co-data published pages: , ISSN: 1471-2105, DOI: 10.1186/s12859-017-1993-1	BMC Bioinformatics 18/1	2019-05-09
2018	E E W Cohen, K J Harrington, D S Hong, R Mesia, I Brana, P Perez Segura, T Wise-Draper, M L Scott, P D Mitchell, G M Mugundu, P McCoon, C E Cook, M Mehta, U Keilholz 1044OA phase Ib/II study (SCORES) of durvalumab (D) plus danvatirsen (DAN; AZD9150) or AZD5069 (CX2i) in advanced solid malignancies and recurrent/metastatic head and neck squamous cell carcinoma (RM-HNSCC): Updated results published pages: viii372-viii399, ISSN: 0923-7534, DOI: 10.1093/annonc/mdy287	Annals of Oncology 29/suppl_8	2019-05-09
2018	I H Nauta, M M Rietbergen, A A J D van Bokhoven, E Bloemena, B I Lissenberg-Witte, D A M Heideman, R J Baatenburg de Jong, R H Brakenhoff, C R Leemans Evaluation of the eighth TNM classification on p16-positive oropharyngeal squamous cell carcinomas in the Netherlands and the importance of additional HPV DNA testing published pages: 1273-1279, ISSN: 0923-7534, DOI: 10.1093/annonc/mdy060	Annals of Oncology 29/5	2019-05-09

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