iRELaTE SIGNED
Immune Response and Social Cognition in Schizophrenia
Total Cost €
0EC-Contrib. €
0Partnership
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0iRELaTE project word cloud
Explore the words cloud of the iRELaTE project. It provides you a very rough idea of what is the project "iRELaTE" about.
Project "iRELaTE" data sheet
The following table provides information about the project.
| Coordinator |
NATIONAL UNIVERSITY OF IRELAND GALWAY
Organization address contact info |
| Coordinator Country | Ireland [IE] |
| Total cost | 1˙477˙622 € |
| EC max contribution | 1˙477˙622 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-07-01 to 2021-06-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | NATIONAL UNIVERSITY OF IRELAND GALWAY | IE (Galway) | coordinator | 1˙477˙622.00 |
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Project objective
Schizophrenia, affecting 0.5-1% of the population, is ranked by the World Health Organisation as more disabling than paraplegia or blindness in 18-34 year olds. Current treatments, developed over 50 years ago, are only partly effective in treating this disability, and new treatments are lacking. To address this treatment impasse, this project aims to develop and test a novel immune based model of deficits in social cognition – the set of mental operations that underlie social interactions (e.g. emotion recognition, theory of mind) and strongly predict social disability in schizophrenia. Based on recent discoveries in schizophrenia genetics, this project asks: (1) are genetic causes of deficits in social cognition mediated by effects on immune function during development and (2) does early social environment moderate these effects? To address these questions, the project has two parts. Part A focuses on neuropsychological and neuroimaging studies of social cognition in patients and healthy adults so as to (1) provide an innovative characterisation of the effects of inflammatory markers (e.g. pro-/anti- inflammatory cytokines) on social cognition, (2) establish whether these markers mediate the effects of recently identified genetic risk loci on schizophrenia, and (3) identify to what extent early social environment (e.g. parental relationships, childhood trauma) moderates this relationship. Part B focuses on behavioural and pharmacological studies in mice to (1) establish the causal effects of early immune challenge and early social environment on social cognition, and (2) test the translational benefits of anti-inflammatory treatment to normalize the resulting deficits. By validating an immune based model of schizophrenia, this project has the potential to move beyond current (dopamine based) treatments, and suggest groundbreaking alternatives for understanding and treating social disability in this and other neurodevelopmental disorders.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
G. Donohoe, J. Holland, D. Mothersill, S. McCarthy-Jones, D. Cosgrove, D. Harold, A. Richards, K. Mantripragada, M. J. Owen, M. C. O\'Donovan, M. Gill, A. Corvin, D. W. Morris Genetically predicted complement component 4A expression: effects on memory function and middle temporal lobe activation published pages: 1-10, ISSN: 0033-2917, DOI: 10.1017/S0033291717002987 |
Psychological Medicine | 2019-07-08 |
| 2017 |
S Kelly, N Jahanshad, A Zalesky, P Kochunov, I Agartz, C Alloza, O A Andreassen, C Arango, N Banaj, S Bouix, C A Bousman, R M Brouwer, J Bruggemann, J Bustillo, W Cahn, V Calhoun, D Cannon, V Carr, S Catts, J Chen, J-x Chen, X Chen, C Chiapponi, Kl K Cho, V Ciullo, A S Corvin, B Crespo-Facorro, V Cropley, P De Rossi, C M Diaz-Caneja, E W Dickie, S Ehrlich, F-m Fan, J Faskowitz, H Fatouros-Bergman, Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group published pages: , ISSN: 1359-4184, DOI: 10.1038/mp.2017.170 |
Molecular Psychiatry | 2019-07-08 |
| 2018 |
Karolina I. Rokita, Maria R. Dauvermann, Gary Donohoe Early life experiences and social cognition in major psychiatric disorders: A systematic review published pages: 123-133, ISSN: 0924-9338, DOI: 10.1016/j.eurpsy.2018.06.006 |
European Psychiatry 53 | 2019-05-10 |
| 2019 |
Maria R. Dauvermann, Gary Donohoe The role of childhood trauma in cognitive performance in schizophrenia and bipolar disorder – A systematic review published pages: 1-11, ISSN: 2215-0013, DOI: 10.1016/j.scog.2018.11.001 |
Schizophrenia Research: Cognition 16 | 2019-05-10 |
| 2018 |
David Mothersill, Rachael Dillon, April Hargreaves, Marco Castorina, Emilia Furey, Andrew J. Fagan, James F. Meaney, Brian Fitzmaurice, Brian Hallahan, Colm McDonald, Til Wykes, Aiden Corvin, Ian H. Robertson, Gary Donohoe Computerised working memory-based cognitive remediation therapy does not affect Reading the Mind in The Eyes test performance or neural activity during a Facial Emotion Recognition test in psychosis published pages: 1691-1705, ISSN: 0953-816X, DOI: 10.1111/ejn.13976 |
European Journal of Neuroscience 48/1 | 2019-05-10 |
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