INVADIS SIGNED
Microbial invasion and dissemination within the host, mechanisms and effects
Total Cost €
0EC-Contrib. €
0Partnership
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0INVADIS project word cloud
Explore the words cloud of the INVADIS project. It provides you a very rough idea of what is the project "INVADIS" about.
Project "INVADIS" data sheet
The following table provides information about the project.
| Coordinator |
INSTITUT PASTEUR
Organization address contact info |
| Coordinator Country | France [FR] |
| Project website | https://research.pasteur.fr/fr/project/erc-2015-cog-invadis/ |
| Total cost | 2˙750˙000 € |
| EC max contribution | 2˙750˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-11-01 to 2021-10-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | INSTITUT PASTEUR | FR (PARIS CEDEX 15) | coordinator | 2˙750˙000.00 |
Map
Project objective
An infection is defined by the deleterious consequences of the interactions between a pathogen and a host. Thus, studying the biology of infection reveals critical properties of hosts and pathogens, and is a way forward to address basic biological questions and improve health. We study listeriosis, a systemic infection caused by Listeria monocytogenes (Lm). Lm is a human foodborne pathogen that crosses the intestinal barrier, disseminates systemically, replicates in liver and spleen and reaches the central nervous system (CNS) and fetoplacental unit. Given the remarkable journey Lm makes in its host, studying listeriosis offers unprecedented opportunities to understand host cell biology, physiology and immune responses, guided by Lm. The mucosal, CNS and fetoplacental tropisms of Lm are shared by other microbes which pathogenesis is far less understood. Lm therefore stands as a unique model microorganism of general biological and medical significance. The major challenge of this project is to go beyond reductionist approaches and embrace the complexity of actual infections. We will use stem cell-derived organoids, live imaging, genetically engineered mouse models, the clinical and biological data from a unique cohort of 900 patients and the corresponding causative Lm strains, to investigate the molecular mechanisms of Lm tissue invasion, dissemination and host responses. Specifically, we will (i) decipher the cell biology of microbial translocation across the intestinal epithelium; (ii) study the impact of microbial portal of entry on microbial fate, dissemination and host responses; (iii) harness Lm biodiversity to identify novel virulence factors and (iv) discover new host factors predisposing to invasive infections. Building on the unique combination of advanced experimental systems and exclusive clinical data, this integrative and innovative project will reveal novel, physiologically relevant mechanisms of infection, with scientific and biomedical implications.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2016 |
Mylène M Maury, Yu-Huan Tsai, Caroline Charlier, Marie Touchon, Viviane Chenal-Francisque, Alexandre Leclercq, Alexis Criscuolo, Charlotte Gaultier, Sophie Roussel, Anne Brisabois, Olivier Disson, Eduardo P C Rocha, Sylvain Brisse, Marc Lecuit Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity published pages: 308-313, ISSN: 1061-4036, DOI: 10.1038/ng.3501 |
Nature Genetics 48/3 | 2019-08-29 |
| 2018 |
Olivier Disson, Camille Blériot, Jean-Marie Jacob, Nicolas Serafini, Sophie Dulauroy, Grégory Jouvion, Cindy Fevre, Grégoire Gessain, Pierre Thouvenot, Gérard Eberl, James P. Di Santo, Lucie Peduto, Marc Lecuit Peyer’s patch myeloid cells infection by Listeria signals through gp38 + stromal cells and locks intestinal villus invasion published pages: 2936-2954, ISSN: 0022-1007, DOI: 10.1084/jem.20181210 |
The Journal of Experimental Medicine 215/11 | 2019-09-04 |
| 2019 |
Mylène M. Maury, Hélène Bracq-Dieye, Lei Huang, Guillaume Vales, Morgane Lavina, Pierre Thouvenot, Olivier Disson, Alexandre Leclercq, Sylvain Brisse, Marc Lecuit Hypervirulent Listeria monocytogenes clones’ adaption to mammalian gut accounts for their association with dairy products published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-10380-0 |
Nature Communications 10/1 | 2019-09-02 |
| 2017 |
Mylène M. Maury, Viviane Chenal-Francisque, Hélène Bracq-Dieye, Lei Han, Alexandre Leclercq, Guillaume Vales, Alexandra Moura, Edith Gouin, Mariela Scortti, Olivier Disson, José A. Vázquez-Boland, Marc Lecuit Spontaneous Loss of Virulence in Natural Populations of Listeria monocytogenes published pages: , ISSN: 0019-9567, DOI: 10.1128/iai.00541-17 |
Infection and Immunity 85/11 | 2019-09-02 |
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