MMDYNASYS SIGNED
Molecular Motors, powering dynamic functional molecular systems
Total Cost €
0EC-Contrib. €
0Partnership
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Project "MMDYNASYS" data sheet
The following table provides information about the project.
| Coordinator |
RIJKSUNIVERSITEIT GRONINGEN
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Project website | http://benferinga.com |
| Total cost | 2˙499˙524 € |
| EC max contribution | 2˙499˙524 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-AdG |
| Funding Scheme | ERC-ADG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-09-01 to 2021-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | RIJKSUNIVERSITEIT GRONINGEN | NL (GRONINGEN) | coordinator | 2˙499˙524.00 |
Map
Project objective
In this proposal the unique properties of unidirectional light driven molecular rotary motors will be built upon to achieve dynamic control of function and develop responsive systems with a particular focus on systems in water. Light-driven molecular rotary motors are distinct from the majority of molecular switches, as they allow sequential access to multiple functional states in a responsive system through non-invasive stimulation. Importantly, continuous irradiation induces continuous rotary motion which provides a unique opportunity to design dynamic systems and responsive materials that can be driven out-of-equilibrium. The research program is divided in four work-packages: a) chemical and redox driven unidirectional motors; here we will develop processive unidirectional motors that can use (electro)chemical energy in a continuous manner, b) amplification of motion; here rotary motors operate in assemblies to amplify mechanical function over a wide range of length scales. Specifically we will use liquid crystal-water interfaces as a unique platform to control motion and organization. c) dissipative self-assembly: molecular motors offer fantastic opportunities to control self-assembly and drive such systems out-of-equilibrium. We aim at metastable aggregate formation (hydrogels) and the design of amphiphilic motors for responsive self-assembled nanostructures; d)triggering biomolecular function; the goal is to use rotary motors to regulate DNA transcription and ultimately as genuine powering device to control cardiac cell function. In the emerging field of photopharmacology, we take advantage of non-invasive high spatio-temporal control that switching with light provides. The proposed research program is highly challenging but provides the comprehensive effort required to achieve control of complex nanomechanical systems and will opening a bright future for applications ranging from stimuli responsive materials to spatio-temporal control of biomolecular systems
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Michael Wegener, Mickel J. Hansen, Arnold J. M. Driessen, Wiktor Szymanski, Ben L. Feringa Photocontrol of Antibacterial Activity: Shifting from UV to Red Light Activation published pages: 17979-17986, ISSN: 0002-7863, DOI: 10.1021/jacs.7b09281 |
Journal of the American Chemical Society 139/49 | 2020-03-20 |
| 2017 |
Bartosz Krajnik, Jiawen Chen, Matthew A. Watson, Scott L. Cockroft, Ben L. Feringa, Johan Hofkens Defocused Imaging of UV-Driven Surface-Bound Molecular Motors published pages: 7156-7159, ISSN: 0002-7863, DOI: 10.1021/jacs.7b02758 |
Journal of the American Chemical Society 139/21 | 2020-03-20 |
| 2017 |
Thomas van Leeuwen, G. Henrieke Heideman, Depeng Zhao, Sander J. Wezenberg, Ben L. Feringa In situ control of polymer helicity with a non-covalently bound photoresponsive molecular motor dopant published pages: 6393-6396, ISSN: 1359-7345, DOI: 10.1039/c7cc03188b |
Chem. Commun. 53/48 | 2020-03-20 |
| 2017 |
Tao Yan, Ben L. Feringa, Katalin Barta Direct N-alkylation of unprotected amino acids with alcohols published pages: eaao6494, ISSN: 2375-2548, DOI: 10.1126/sciadv.aao6494 |
Science Advances 3/12 | 2020-03-20 |
| 2018 |
Diederik Roke, Sander J. Wezenberg, Ben L. Feringa Molecular rotary motors: Unidirectional motion around double bonds published pages: 9423-9431, ISSN: 0027-8424, DOI: 10.1073/pnas.1712784115 |
Proceedings of the National Academy of Sciences 115/38 | 2020-03-20 |
| 2017 |
Jiřà Kaleta, Jiawen Chen, Guillaume Bastien, Martin DraÄÃnský, Milan Mašát, Charles T. Rogers, Ben L. Feringa, Josef Michl Surface Inclusion of Unidirectional Molecular Motors in Hexagonal Tris( o -phenylene)cyclotriphosphazene published pages: 10486-10498, ISSN: 0002-7863, DOI: 10.1021/jacs.7b05404 |
Journal of the American Chemical Society 139/30 | 2020-03-20 |
| 2018 |
Jiawen Chen, Jérôme Vachon, Ben L. Feringa Design, Synthesis, and Isomerization Studies of Light-Driven Molecular Motors for Single Molecular Imaging published pages: 6025-6034, ISSN: 0022-3263, DOI: 10.1021/acs.joc.8b00654 |
The Journal of Organic Chemistry 83/11 | 2020-03-20 |
| 2017 |
Thomas van Leeuwen, Anouk S. Lubbe, Peter Å tacko, Sander J. Wezenberg, Ben L. Feringa Dynamic control of function by light-driven molecular motors published pages: 96, ISSN: 2397-3358, DOI: 10.1038/s41570-017-0096 |
Nature Reviews Chemistry 1/12 | 2020-03-20 |
| 2017 |
Jos C. M. Kistemaker, Peter Å tacko, Diederik Roke, Alexander T. Wolters, G. Henrieke Heideman, Mu-Chieh Chang, Pieter van der Meulen, Johan Visser, Edwin Otten, Ben L. Feringa Third-Generation Light-Driven Symmetric Molecular Motors published pages: 9650-9661, ISSN: 0002-7863, DOI: 10.1021/jacs.7b04412 |
Journal of the American Chemical Society 139/28 | 2020-03-20 |
| 2018 |
Thomas van Leeuwen, Wojciech Danowski, Stefano F. Pizzolato, Peter Štacko, Sander J. Wezenberg, Ben L. Feringa Braking of a Light-Driven Molecular Rotary Motor by Chemical Stimuli published pages: 81-84, ISSN: 0947-6539, DOI: 10.1002/chem.201704747 |
Chemistry - A European Journal 24/1 | 2020-03-20 |
| 2017 |
Anouk S. Lubbe, Sander J. Wezenberg, Ben L. Feringa Artificial microtubules burst with energy published pages: 11804-11805, ISSN: 0027-8424, DOI: 10.1073/pnas.1716868114 |
Proceedings of the National Academy of Sciences 114/45 | 2020-03-20 |
| 2018 |
Anouk S. Lubbe, Qing Liu, Sanne J. Smith, Jan Willem de Vries, Jos C. M. Kistemaker, Alex H. de Vries, Ignacio Faustino, Zhuojun Meng, Wiktor Szymanski, Andreas Herrmann, Ben L. Feringa Photoswitching of DNA Hybridization Using a Molecular Motor published pages: 5069-5076, ISSN: 0002-7863, DOI: 10.1021/jacs.7b09476 |
Journal of the American Chemical Society 140/15 | 2020-03-20 |
| 2017 |
Thomas van Leeuwen, Wojciech Danowski, Edwin Otten, Sander J. Wezenberg, Ben L. Feringa Asymmetric Synthesis of Second-Generation Light-Driven Molecular Motors published pages: 5027-5033, ISSN: 0022-3263, DOI: 10.1021/acs.joc.7b00852 |
The Journal of Organic Chemistry 82/10 | 2020-03-20 |
| 2017 |
Peter Å tacko, Jos C. M. Kistemaker, Thomas van Leeuwen, Mu-Chieh Chang, Edwin Otten, Ben L. Feringa Locked synchronous rotor motion in a molecular motor published pages: 964-968, ISSN: 0036-8075, DOI: 10.1126/science.aam8808 |
Science 356/6341 | 2020-03-20 |
| 2018 |
Christopher R. Hall, Wesley R. Browne, Ben L. Feringa, Stephen R. Meech Mapping the Excited-State Potential Energy Surface of a Photomolecular Motor published pages: 6203-6207, ISSN: 1433-7851, DOI: 10.1002/anie.201802126 |
Angewandte Chemie International Edition 57/21 | 2020-03-20 |
| 2018 |
Sander J. Wezenberg, Ben L. Feringa Supramolecularly directed rotary motion in a photoresponsive receptor published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04249-x |
Nature Communications 9/1 | 2020-03-20 |
| 2017 |
Thomas van Leeuwen, Jasper Pol, Diederik Roke, Sander J. Wezenberg, Ben L. Feringa Visible-Light Excitation of a Molecular Motor with an Extended Aromatic Core published pages: 1402-1405, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b00317 |
Organic Letters 19/6 | 2020-03-20 |
| 2017 |
Salma Kassem, Thomas van Leeuwen, Anouk S. Lubbe, Miriam R. Wilson, Ben L. Feringa, David A. Leigh Artificial molecular motors published pages: 2592-2621, ISSN: 0306-0012, DOI: 10.1039/c7cs00245a |
Chemical Society Reviews 46/9 | 2020-03-20 |
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