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ES-Cat SIGNED

Directed Protein Evolution for Synthetic Biology and Biocatalysis

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

ES-Cat project word cloud

Explore the words cloud of the ES-Cat project. It provides you a very rough idea of what is the project "ES-Cat" about.

disciplines chip forces generation industrial sequence creative complementary proteins represented levels ribozyme engineering darwinian perfection integration functions fill kinetic libraries socio machines seeing enzyme microfluidics exploration manipulated skills ready tool throughput train biotechnology display combinatorial instead roles mechanisms made applicable perform liquid systematic optimize es combine enzymes screening biophysical robotic protein biocatalyst evolution network medicine combining silico groups handling rivaling times structural space remarkable benefits evident laboratory tailoring experimental campaigns harnessing reproduce phage molecular generate snap brings nature efficient near economic lab directed subsequent move efforts biology diverse rational economy academic cat screen shorten synthetic bio alternatives smarter harvest

Project "ES-Cat" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://es-cat.online/
Total cost	3˙827˙031 €
EC max contribution	3˙827˙031 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2016
Funding Scheme	MSCA-ITN-ETN
Starting year	2017
Duration (year-month-day)	from 2017-03-01 to 2021-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	273˙287.00
2	MEDIMMUNE LIMITED MEDIMMUNE LIMITED Organization address address: MILSTEIN BUILDING GRANTA PARK city: CAMBRIDGE postcode: CB21 6GH website: http://www.cambridgeantibody.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	546˙575.00
3	RIJKSUNIVERSITEIT GRONINGEN RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	participant	510˙748.00
4	UNIVERSITE CATHOLIQUE DE LOUVAIN UNIVERSITE CATHOLIQUE DE LOUVAIN Organization address address: PLACE DE L UNIVERSITE 1 city: LOUVAIN LA NEUVE postcode: 1348 website: www.uclouvain.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LOUVAIN LA NEUVE)	participant	501˙120.00
5	UNIVERSITAET GREIFSWALD UNIVERSITAET GREIFSWALD Organization address address: DOMSTRASSE 11 city: GREIFSWALD postcode: 17489 website: www.uni-greifswald.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (GREIFSWALD)	participant	498˙432.00
6	WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER Organization address address: SCHLOSSPLATZ 2 city: MUENSTER postcode: 48149 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENSTER)	participant	498˙432.00
7	JOHNSON MATTHEY PLC JOHNSON MATTHEY PLC Organization address address: FARRINGDON STREET 25 5TH FLOOR city: LONDON postcode: EC4A 4AB website: www.matthey.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	273˙287.00
8	BEN-GURION UNIVERSITY OF THE NEGEV BEN-GURION UNIVERSITY OF THE NEGEV Organization address address: . city: BEER SHEVA postcode: 84105 website: www.bgu.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (BEER SHEVA)	participant	260˙300.00
9	ENANTIS SRO ENANTIS SRO Organization address address: KAMENICE 771/34 city: BRNO postcode: 625 00 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (BRNO)	participant	232˙422.00
10	FAKULTNI NEMOCNICE U SV. ANNY V BRNE FAKULTNI NEMOCNICE U SV. ANNY V BRNE Organization address address: Pekarska 53 city: Brno postcode: 656 91 website: www.fnusa.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (Brno)	participant	232˙422.00
11	Alzheimer's Research UK Alzheimer's Research UK Organization address address: 43-44 CRUTCHED FRIARS city: LONDON postcode: EC3N 2AE website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	partner	0.00
12	Brain AG Brain AG Organization address address: Darmstädter Straße 34-36 city: Zwingenberg postcode: 64673 website: www.brain-biotech.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Zwingenberg)	partner	0.00
13	CAMBRIDGE ENTREPRISE LIMITED CAMBRIDGE ENTREPRISE LIMITED Organization address address: CHARLES BABBAGE ROAD HAUSER FORUM 3 city: CAMBRIDGE postcode: CB3 0GT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	partner	0.00
14	DROP-TECH LTD DROP-TECH LTD Organization address address: Canterbury Street, Canterbury Court 91 city: Cambridge postcode: CB4 3QU website: http://www.drop-tech.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Cambridge)	partner	0.00
15	DSM FOOD SPECIALTIES BV DSM FOOD SPECIALTIES BV Organization address address: ALEXANDER FLEMINGLAAN 1 city: DELFT postcode: 2613 AX website: www.dsmfoodspecialties.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DELFT)	partner	0.00
16	Enzymicals Enzymicals Organization address address: WALTHER-RATHENAU-STRASSE 49A city: GREIFSWALD postcode: 17489 website: www.enzymicals.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (GREIFSWALD)	partner	0.00
17	GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. Organization address address: Great West Road 980 city: BRENTFORD postcode: TW89GS website: www.gsk.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRENTFORD)	partner	0.00
18	Kamada Kamada Organization address address: 7 Sapir St., Kiryat Weizmann Science Park, P.O 4081, 7414002 city: Ness-Ziona postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (Ness-Ziona)	partner	0.00
19	NOVOZYMES A/S NOVOZYMES A/S Organization address address: Krogshoejvej 36 city: BAGSVAERD postcode: 2880 website: www.novozymes.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (BAGSVAERD)	partner	0.00

Map

Project objective

ES-Cat will use directed evolution as a tool to reproduce Nature's remarkable ability to generate molecular machines - in particular enzymes – that perform at levels near perfection. Instead of seeing rational and combinatorial approaches as alternatives, we combine them in this network to achieve a ‘smarter’ and more efficient exploration of protein sequence space. By harnessing the forces of Darwinian evolution and design in the laboratory we want to (i) screen large and diverse libraries for proteins with improved and useful functions, (ii) optimize existing proteins for applications in medicine or biotechnology and (iii) provide a better understanding of how existing enzymes evolved and how enzyme mechanisms can be manipulated. This Network brings together leading academic and industrial groups with diverse and complementary skills. The range of methodologies represented in ES-Cat allows an integrated approach combining in silico structural and sequence analysis with experimental high-throughput screening selection methods (phage-, ribozyme and SNAP display, robotic liquid handling, lab-on-a-chip/microfluidics) with subsequent systematic kinetic and biophysical analysis. This integration of methods and disciplines will improve the likelihood of success of directed evolution campaigns, shorten biocatalyst development times, and make protein engineering applicable to a wider range of industrial targets. It will also train the next generation of creative researchers ready to fill roles in tailoring enzymes and other proteins for industrial application in synthetic biology efforts to move towards a bio-based economy, rivaling advances that are being made in the US and allowing the EU economy to harvest its evident socio-economic benefits.

Deliverables

List of deliverables.
Open Day	Other	2020-03-23 11:31:14
Social media presence (Facebook)	Websites, patent fillings, videos etc.	2020-03-23 11:31:13
Website, ESR webpages and CamTools operational	Websites, patent fillings, videos etc.	2020-03-23 11:31:13

Take a look to the deliverables list in detail: detailed list of ES-Cat deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Stanislav Mazurenko, Jan Stourac, Antonin Kunka, Sava NedeljkoviÄ‡, David Bednar, Zbynek Prokop, Jiri Damborsky CalFitter: a web server for analysis of protein thermal denaturation data published pages: W344-W349, ISSN: 0305-1048, DOI: 10.1093/nar/gky358	Nucleic Acids Research 46/W1	2020-03-23
2018	Lenka Sumbalova, Jan Stourac, Tomas Martinek, David Bednar, Jiri Damborsky HotSpot Wizard 3.0: web server for automated design of mutations and smart libraries based on sequence input information published pages: W356-W362, ISSN: 0305-1048, DOI: 10.1093/nar/gky417	Nucleic Acids Research 46/W1	2020-03-23
2018	Danielle Dahan, Ioannis Tsirkas, Daniel Dovrat, Melanie A Sparks, Saurabh P Singh, Roberto Galletto, Amir Aharoni Pif1 is essential for efficient replisome progression through lagging strand G-quadruplex DNA secondary structures published pages: 11847-11857, ISSN: 0305-1048, DOI: 10.1093/nar/gky1065	Nucleic Acids Research 46/22	2020-03-23
2018	Daniel Dovrat, Danielle Dahan, Shachar Sherman, Ioannis Tsirkas, Natalie Elia, Amir Aharoni A Live-Cell Imaging Approach for Measuring DNA Replication Rates published pages: 252-258, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.06.018	Cell Reports 24/1	2020-03-23
2018	Koen Beerens, Stanislav Mazurenko, Antonin Kunka, Sergio M. Marques, Niels Hansen, Milos Musil, Radka Chaloupkova, Jitka Waterman, Jan Brezovsky, David Bednar, Zbynek Prokop, Jiri Damborsky Evolutionary Analysis As a Powerful Complement to Energy Calculations for Protein Stabilization published pages: 9420-9428, ISSN: 2155-5435, DOI: 10.1021/acscatal.8b01677	ACS Catalysis 8/10	2020-03-23
2018	Pavel Vanacek, Eva Sebestova, Petra Babkova, Sarka Bidmanova, Lukas Daniel, Pavel Dvorak, Veronika Stepankova, Radka Chaloupkova, Jan Brezovsky, Zbynek Prokop, Jiri Damborsky Exploration of Enzyme Diversity by Integrating Bioinformatics with Expression Analysis and Biochemical Characterization published pages: 2402-2412, ISSN: 2155-5435, DOI: 10.1021/acscatal.7b03523	ACS Catalysis 8/3	2020-03-23
2018	Or Gertman, Dotan Omer, Adi Hendler, Daniel Stein, Lior Onn, Yana Khukhin, Miguel Portillo, Raz Zarivach, Haim Y. Cohen, Debra Toiber, Amir Aharoni Directed evolution of SIRT6 for improved deacylation and glucose homeostasis maintenance published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-21887-9	Scientific Reports 8/1	2020-03-23
2018	Dana Koslawsky, Marianna Zaretsky, Ron Alcalay, Ohad Mazor, Amir Aharoni, Niv Papo A bi-specific inhibitor targeting IL-17A and MMP-9 reduces invasion and motility in MDA-MB-231 cells published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.25526	Oncotarget 9/47	2020-03-23

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