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SYNC_DEV SIGNED

The importance of transcriptional coordination during development

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SYNC_DEV project word cloud

Explore the words cloud of the SYNC_DEV project. It provides you a very rough idea of what is the project "SYNC_DEV" about.

newly bookmarking fixed regulation connect mother enhancer expression initially insights daughter artificially integrate multicellular living fate disease transcription embryo regions live enhancers sequence examine gene manipulations synchrony mechanisms inheritance fundamental functional nuclear drosophila transcriptional specification cell promoter imaging extend responsible activation explore cardiogenesis ultimate refers precisely timing little model quantitative stages space questions genetic reconstituted spatial dynamics time team priming coordinately regulatory organism technique snapshots understand metazoan tissue temporal preparations inter organisms dynamic cells memory homogeneity stem precision normal later mrna integration

Project "SYNC_DEV" data sheet

The following table provides information about the project.

Coordinator	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	1˙500˙000 €
EC max contribution	1˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-STG
Funding Scheme	ERC-STG
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	1˙500˙000.00

Map

Project objective

Gene expression is precisely controlled in time and space during the development of Metazoan organisms. While numerous studies have established how spatial information is integrated by gene regulatory regions, called enhancers, little is known about the temporal aspects of transcription. Most of our insights into gene regulation stem from the use of fixed preparations where timing is artificially reconstituted from different snapshots. My goal is to integrate the dynamic aspects of transcription to understand how coordination is achieved and whether it is required during development. Transcriptional coordination refers to the inter-nuclear temporal coordination in gene activation (synchrony) and homogeneity in mRNA distribution across a field of coordinately developing cells. Initially we will characterize the mechanisms of transcriptional coordination in the early Drosophila embryo, a model system which allows quantitative imaging and genetic manipulations. However the ultimate goal of the programme is to extend these analyses to later stages of development during complex tissue specification. My team will improve a newly available live imaging technique to address fundamental questions about transcriptional dynamics in a multicellular developing embryo, with three main objectives: 1-examine the effects of promoter sequence and enhancer priming on transcriptional coordination. 2-analyse the inheritance of transcriptional states from mother to daughter cells and identify the bookmarking mechanisms responsible for this memory. 3-explore the functional role of transcriptional coordination for cell fate specification during cardiogenesis. Through the novel integration of the dynamic and quantitative aspects of transcription in a living organism, this study shall connect coordination in transcription to precision in cell specification. Thus, results from this research should have major impact on our understanding of gene regulation during normal development and disease

Publications

List of publications.
year	authors and title	journal	last update
2019	A Trullo, J Dufourt, M Lagha MitoTrack, a user-friendly semi-automatic software for lineage tracking in living embryos published pages: , ISSN: 1367-4803, DOI: 10.1093/bioinformatics/btz717	Bioinformatics	2020-03-05
2018	Xavier Pichon, Mounia Lagha, Florian Mueller, Edouard Bertrand A Growing Toolbox to Image Gene Expression in Single Cells: Sensitive Approaches for Demanding Challenges published pages: 468-480, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2018.07.022	Molecular Cell 71/3	2020-03-05
2018	Maelle Bellec, Ovidiu Radulescu, Mounia Lagha Remembering the past: Mitotic bookmarking in a developing embryo published pages: 41-49, ISSN: 2452-3100, DOI: 10.1016/j.coisb.2018.08.003	Current Opinion in Systems Biology 11	2019-09-04
2019	AndrÃ©s M. Cardozo Gizzi, Diego I. Cattoni, Jean-Bernard Fiche, Sergio M. Espinola, Julian Gurgo, Olivier Messina, Christophe Houbron, Yuki Ogiyama, Giorgio L. Papadopoulos, Giacomo Cavalli, Mounia Lagha, Marcelo Nollmann Microscopy-Based Chromosome Conformation Capture Enables Simultaneous Visualization of Genome Organization and Transcription in Intact Organisms published pages: 212-222.e5, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.01.011	Molecular Cell 74/1	2019-09-04

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