EVOIMMECH SIGNED
The evolutionary ecology of bacterial immune mechanisms
Total Cost €
0EC-Contrib. €
0Partnership
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Project "EVOIMMECH" data sheet
The following table provides information about the project.
| Coordinator |
THE UNIVERSITY OF EXETER
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 1˙498˙337 € |
| EC max contribution | 1˙498˙337 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-01-01 to 2021-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE UNIVERSITY OF EXETER | UK (EXETER) | coordinator | 1˙435˙837.00 |
| 2 | UNIVERSITY OF OTAGO | NZ (DUNEDIN) | participant | 62˙500.00 |
Map
Project objective
Bacteria have a range of immune mechanisms, but it is unclear why this diverse armamentarium evolved. The most important immune mechanisms are (1) Surface Modification (SM) (2) Abortive infection (Abi) (3) Restriction Modification (R-M) (4) CRISPR-Cas and (5) prokaryotic Argonaute (pAgo), all of which can occur as stand-alone mechanisms or in combination. The individual mechanisms differ in key aspects, such as their fitness costs (constitutive versus inducible), specificity (indiscriminate versus specific), the recipient of the benefits (individual versus group), the speed of de novo resistance evolution (rapid versus slow), and heritability of immunity. Here I will take a combined in vitro and in vivo approach to tease apart the variables that drive the evolution of these diverse stand-alone and integrated bacterial immune strategies in nature, and examine their associated co-evolutionary dynamics. I focus on three ecological variables that are consistently important in host-symbiont co-evolution: (1) force of infection (2) spatial structure (3) presence of mutualists (plasmids). First, I will perform in vitro manipulations using Pseudomonas aeruginosa PA14 variants that carry either single or multiple immune mechanisms. Next, I will sequence metagenomes, transcriptomes and viromes of microbial communities from environments that differ in ecological variables that are important in vitro, to examine their importance in vivo. Key ecological mechanisms identified in the first two parts of the project will be used to guide mesocosm experiments to experimentally confirm that these mechanisms are the drivers of the observed patterns of resistance and co-evolution in nature. Finally, I will share my data with mathematical biologists to generate theoretical models to predict and manipulate the evolution of bacterial immune mechanisms, which will facilitate tailored species protection in agriculture and industry.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Hélène Chabas, Antoine Nicot, Sean Meaden, Edze R. Westra, Denise M. Tremblay, Léa Pradier, Sébastien Lion, Sylvain Moineau, Sylvain Gandon Variability in the durability of CRISPR-Cas immunity published pages: 20180097, ISSN: 0962-8436, DOI: 10.1098/rstb.2018.0097 |
Philosophical Transactions of the Royal Society B: Biological Sciences 374/1772 | 2019-08-29 |
| 2019 |
Jack Common, Daniel Morley, Edze R. Westra, Stineke van Houte CRISPR-Cas immunity leads to a coevolutionary arms race between Streptococcus thermophilus and lytic phage published pages: 20180098, ISSN: 0962-8436, DOI: 10.1098/rstb.2018.0098 |
Philosophical Transactions of the Royal Society B: Biological Sciences 374/1772 | 2019-08-29 |
| 2018 |
Hélène Chabas, Sébastien Lion, Antoine Nicot, Sean Meaden, Stineke van Houte, Sylvain Moineau, Lindi M. Wahl, Edze R. Westra, Sylvain Gandon Evolutionary emergence of infectious diseases in heterogeneous host populations published pages: e2006738, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.2006738 |
PLOS Biology 16/9 | 2019-08-29 |
| 2018 |
Mariann Landsberger, Sylvain Gandon, Sean Meaden, Clare Rollie, Anne Chevallereau, Hélène Chabas, Angus Buckling, Edze R. Westra, Stineke van Houte Anti-CRISPR Phages Cooperate to Overcome CRISPR-Cas Immunity published pages: 908-916.e12, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.05.058 |
Cell 174/4 | 2019-08-29 |
| 2018 |
Jack Common, Edze R. Westra CRISPR evolution and bacteriophage persistence in the context of population bottlenecks published pages: 588-594, ISSN: 1547-6286, DOI: 10.1080/15476286.2019.1578608 |
RNA Biology 16/4 | 2019-08-29 |
| 2019 |
Anne Chevallereau, Sean Meaden, Stineke van Houte, Edze R. Westra, Clare Rollie The effect of bacterial mutation rate on the evolution of CRISPR-Cas adaptive immunity published pages: 20180094, ISSN: 0962-8436, DOI: 10.1098/rstb.2018.0094 |
Philosophical Transactions of the Royal Society B: Biological Sciences 374/1772 | 2019-08-29 |
| 2018 |
Elizabeth Pursey, David Sünderhauf, William H. Gaze, Edze R. Westra, Stineke van Houte CRISPR-Cas antimicrobials: Challenges and future prospects published pages: e1006990, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1006990 |
PLOS Pathogens 14/6 | 2019-08-29 |
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