Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. fatemapb

FatemapB SIGNED

High Resolution Mapping of Fetal and Adult B Cell Fates During Ontogeny

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 FatemapB project word cloud

Explore the words cloud of the FatemapB project. It provides you a very rough idea of what is the project "FatemapB" about.

switch    division    utility    me    replenished    mature    molecular    dissection    host    resolution    lin28b    self    complementary    mediated    et    situ    unattainable    window    recombination    single    cell    leukemogenesis    resolve    assessing    b1a    sustain    contribution    stem    cre    identity    vivo    labor    qualitative    mechanism    post    limited    disputed    functionally    barcoding    herein    emphasis    relationship    protection    2012    normal    emerge    progenitor    regeneration    hematopoiesis    functions    stratify    marrow    transcriptional    b2    mammalian    discovery    lymphopoiesis    developmental    al    provides    types    implications    fatemapb    effector    time    inducing    perspectives    function    cells    inducible    fetal    technologies    ultimately    immune    fates    age    fundamental    clinical    hematopoietic    unclear    generating    surprisingly    tracing    mosaic    afforded    differentiation    quantitative    binding    repertoire    combinatorial    science    yuan    life    cellular    lineage    previously    understand    hspcs    bone    rna    adult    renewal    protein    extend   

Project "FatemapB" data sheet

The following table provides information about the project.

Coordinator		 LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Sweden [SE]
 Total cost 1˙499˙905 €
 EC max contribution 1˙499˙905 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 1˙499˙905.00

Map

 Project objective

FateMapB aims to understand how the unique differentiation potential of fetal hematopoietic stem and progenitor cells (HSPCs) contribute to functionally distinct cell types of the adult immune system. While most immune cells are replenished by HSPCs through life, others emerge during a limited window in fetal life and sustain through self-renewal in situ. The lineage identity of fetal HSPCs, and the extent of their contribution to the adult immune repertoire remain surprisingly unclear. I previously identified the fetal specific RNA binding protein Lin28b as a post-transcriptional molecular switch capable of inducing fetal-like hematopoiesis in adult bone marrow HSPCs (Yuan et al. Science, 2012). This discovery has afforded me with unique perspectives on the formation of the mammalian immune system. The concept that the mature immune system is a mosaic of fetal and adult derived cell types is addressed herein with an emphasis on the B cell lineage. We will use two complementary lineage-tracing technologies to stratify the immune system as a function of developmental time, generating fundamental insight into the division of labor between fetal and adult HSPCs that ultimately provides effective host protection. Aim 1. Determine the qualitative and quantitative contribution of fetal HSPCs to the mature immune repertoire in situ through Cre recombination mediated lineage-tracing. Aim 2. Resolve the disputed lineage relationship between fetal derived B1a cells and adult derived B2 cells by single cell lineage-tracing using cellular barcoding in vivo. Aim 3. Characterize the mechanism and effector functions of Lin28b induced B1a cell development for assessing the clinical utility of inducible fetal-like lymphopoiesis. The implications of FateMapB extend beyond normal development to immune regeneration and age-related features of leukemogenesis. Finally, our combinatorial lineage-tracing approach enables dissection of cell fates with previously unattainable resolution.

 Publications

year authors and title journal last update
List of publications.
2018 Trine A Kristiansen, Stijn Vanhee, Joan Yuan
The influence of developmental timing on B cell diversity
published pages: , ISSN: 0952-7915, DOI: 		Current Opinion in Immunology 2019-06-06
2017 Dan Su, Stijn Vanhee, Rebeca Soria, Elin Jaensson Gyllenbäck, Linda M. Starnes, Martina Kubec Højfeldt, Gabriel K. Pedersen, Joan Yuan, and Jeremy A. Daniel
PTIP chromatin regulator controls development and activation of B cell subsets to license humoral immunity in mice
published pages: , ISSN: 0027-8424, DOI: 		PNAS 2019-06-06

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FATEMAPB" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "FATEMAPB" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

CHIPTRANSFORM (2018)

On-chip optical communication with transformation optics

Read More  

AST (2019)

Automatic System Testing

Read More  

OAlipotherapy (2018)

Long-retention liposomic drug-delivery for intra-articular osteoarthritis therapy

Read More