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SupraCarrier

Supramolecular hydrogels as local controlled drug delivery carriers

Total Cost €

EC-Contrib. €

Partnership

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SupraCarrier project word cloud

Explore the words cloud of the SupraCarrier project. It provides you a very rough idea of what is the project "SupraCarrier" about.

carriers temporal unmet ing locations demonstrated profile either proof versatile supramolecular local initial substantial injectability location pyrimidinone designed bioactive medical difficult assembly modification display strategies commercial adjustment minimally sustained structure drugs depending vitro carrier rate thereby adjusted hydrogels burst invasive doses physicochemical limited prioritise supracarrier points limiting chemical vehicles drug clinical validate surgical degradation selling ureido platform release totally composition spatiotemporally injectable body convenient feasibility agents upy macroscale tuned material capacity implantation kinetics hydrogel

Project "SupraCarrier" data sheet

The following table provides information about the project.

Coordinator	TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-PoC
Funding Scheme	ERC-POC
Starting year	2017
Duration (year-month-day)	from 2017-02-01 to 2018-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITEIT EINDHOVEN TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (EINDHOVEN)	coordinator	150˙000.00

Map

Project objective

In recent years, macroscale drug delivery systems have been designed and investigated to spatiotemporally control the release of various bioactive agents and drugs at specific locations in the body. Many of these macroscale drug delivery vehicles are based on hydrogels. Depending on the location of application, and the temporal release kinetics, these hydrogel drug carriers need to be adjusted to the need of the application. Many of the currently available hydrogel systems do not have the capacity to be totally tuned. These systems: a) display a substantial initial burst release of the drug resulting in high drug doses at the initial phase; b) are difficult to apply (surgical implantation is necessary for various systems, thereby limiting their potential of easy/convenient application); c) provide only limited opportunities for chemical adjustment of their composition to improve key material properties such as their release kinetics and/or degradation rate. SupraCarrier aims to address these unmet needs by developing an injectable, supramolecular ureido-pyrimidinone (UPy) based hydrogel (UPy-hydrogel) drug delivery system that allows for local and sustained drug release. The unique selling points of this UPy-hydrogel system are: a) its demonstrated sustained drug release profile in vitro (with no initial burst release); b) its injectability due to its unique physicochemical properties (that allow for the development of clinical strategies using minimally invasive procedures); and c) its chemical structure and supramolecular assembly behaviour which allows for easy modification of either the UPy-hydrogel carrier or the drug (resulting in a versatile drug delivery platform). With SupraCarrier we aim to a) validate the commercial feasibility of a UPy-hydrogel as a novel local drug delivery system for controlled (and sustained) drug release; b) prioritise the medical applications where this system can be used; and c) provide a proof of concept for using a UPy-hydrogel

Publications

List of publications.
year	authors and title	journal	last update
2018	Maarten H. Bakker, Maxime Grillaud, Dan Jing Wu, Peter-Paul K. H. Fransen, Ignace H. de Hingh, Patricia Y. W. Dankers Cholesterol Modification of an Anticancer Drug for Efficient Incorporation into a Supramolecular Hydrogel System published pages: 1800007, ISSN: 1022-1336, DOI: 10.1002/marc.201800007	Macromolecular Rapid Communications 39/17	2019-10-08

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The information about "SUPRACARRIER" are provided by the European Opendata Portal: CORDIS opendata.