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MECHANO-CONTROL SIGNED

Mechanical control of biological function

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MECHANO-CONTROL project word cloud

Explore the words cloud of the MECHANO-CONTROL project. It provides you a very rough idea of what is the project "MECHANO-CONTROL" about.

technologies regenerative activation nanometre mechanical uncharted integrate metre principles tissues medicine biomaterials model abrogate microenvironments integrating driving organism oncology cancer adhesive drive force function combine stages data magnetic strategies mouse tumour dynamically therapeutic mechanics cells cellular paradigm applicability impair time tweezers biomaterial trough community matrix molecule scales peptidomimetics organ building molecular realised atomic rules interactions experimental nanometric microscopy bonds cell manipulate disparate hold transmitted techniques enabled interfering space single forces treatment computational photo ligands breast interdisciplinary progression adhesion biological

Project "MECHANO-CONTROL" data sheet

The following table provides information about the project.

Coordinator	FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA Organization address address: CARRER BALDIRI REIXAC PLANTA 2A 10-12 city: BARCELONA postcode: 8028 website: http://www.ibecbarcelona.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://mechanocontrol.eu/
Total cost	7˙134˙928 €
EC max contribution	7˙134˙928 € (100%)
Programme	1. H2020-EU.1.2.2. (FET Proactive)
Code Call	FETPROACT-2016
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA Organization address address: CARRER BALDIRI REIXAC PLANTA 2A 10-12 city: BARCELONA postcode: 8028 website: http://www.ibecbarcelona.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	coordinator	1˙952˙419.00
2	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	2˙337˙450.00
3	NOVIOCELL BV NOVIOCELL BV Organization address address: KLOOSTERSTRAAT 9 RE1131 city: OSS postcode: 5349 AB website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (OSS)	participant	710˙500.00
4	KING'S COLLEGE LONDON KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	706˙715.00
5	LEIBNIZ-INSTITUT FUER NEUE MATERIALIEN GEMEINNUETZIGE GMBH LEIBNIZ-INSTITUT FUER NEUE MATERIALIEN GEMEINNUETZIGE GMBH Organization address address: CAMPUS D2 2 city: SAARBRUECKEN postcode: 66123 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (SAARBRUECKEN)	participant	662˙000.00
6	UNIVERSITAT POLITECNICA DE CATALUNYA UNIVERSITAT POLITECNICA DE CATALUNYA Organization address address: CALLE JORDI GIRONA 31 city: BARCELONA postcode: 8034 website: www.upc.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	638˙000.00
7	MIND THE BYTE SL MIND THE BYTE SL Organization address address: CALLE MANSO 76 PRINCIPAL 1 city: BARCELONA postcode: 8015 website: www.mindthebyte.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	127˙844.00

Map

Project objective

Mechanical forces transmitted through specific molecular bonds drive biological function, and their understanding and control hold an uncharted potential in oncology, regenerative medicine and biomaterial design. However, this potential has not been realised, because it requires developing and integrating disparate technologies to measure and manipulate mechanical and adhesive properties from the nanometre to the metre scale. We propose to address this challenge by building an interdisciplinary research community with the aim of understanding and controlling cellular mechanics from the molecular to the organism scale. At the nanometric molecular level, we will develop cellular microenvironments enabled by peptidomimetics of cell-cell and cell-matrix ligands, with defined mechanical and adhesive properties that we will dynamically control in time and space trough photo-activation. The properties under force of the molecular bonds involved will be characterized using single-molecule atomic force microscopy and magnetic tweezers. At the cell-to-organ scale, we will combine controlled microenvironments and interfering strategies with the development of techniques to measure and control mechanical forces and adhesion in cells and tissues, and to evaluate their biological response. At the organism scale, we will establish how cellular mechanics can be controlled, by targeting specific adhesive interactions, to impair or abrogate breast tumour progression in a mouse model. At all stages and scales of the project, we will integrate experimental data with multi-scale computational modelling to establish the rules driving biological response to mechanics and adhesion. With this approach, we aim to develop specific therapeutic approaches beyond the current paradigm in breast cancer treatment. Beyond breast cancer, the general principles targeted by our technology will have high applicability in oncology, regenerative medicine and biomaterials.

Deliverables

List of deliverables.
Summer school	Websites, patent fillings, videos etc.	2020-02-19 16:51:09
Updated Plan for the Exploitation and Dissemination of Results M30	Documents, reports	2020-02-19 16:51:09
Set-up of the continuum model coupling adhesion, cortex, membrane and matrix	Other	2020-02-19 16:51:09
Characterization of mechanical and adhesive factors driving sub-cellular behaviour	Documents, reports	2020-02-19 16:51:09
Set-up of the discrete stochastic models for bond clusters	Other	2020-02-19 16:51:07
Updated Plan for the Exploitation and Dissemination of Results M12	Documents, reports	2020-02-19 16:51:07
Logo and Public website of the project	Websites, patent fillings, videos etc.	2020-02-19 16:51:07
Plan for the Exploitation and Dissemination of Results	Documents, reports	2020-02-19 16:51:07

Take a look to the deliverables list in detail: detailed list of MECHANO-CONTROL deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Roshna V. Nair, Aleeza Farrukh, ArÃ¡nzazu delâ€…Campo A Photoactivatable Î± 5 Î² 1 -Specific Integrin Ligand published pages: 1280-1287, ISSN: 1439-4227, DOI: 10.1002/cbic.201800180	ChemBioChem 19/12	2020-02-19
2018	Heather C. Bruner, Patrick W.B. Derksen Loss of E-Cadherin-Dependent Cellâ€“Cell Adhesion and the Development and Progression of Cancer published pages: a029330, ISSN: 1943-0264, DOI: 10.1101/cshperspect.a029330	Cold Spring Harbor Perspectives in Biology 10/3	2020-02-19
2018	Jorge Escribano, Raimon Sunyer, MarÃa Teresa SÃ¡nchez, Xavier Trepat, Pere Roca-Cusachs, JosÃ© Manuel GarcÃa-Aznar A hybrid computational model for collective cell durotaxis published pages: 1037-1052, ISSN: 1617-7959, DOI: 10.1007/s10237-018-1010-2	Biomechanics and Modeling in Mechanobiology 17/4	2020-02-19
2019	Aleeza Farrukh, Julieta I. Paez, ArÃ¡nzazu del Campo 4D Biomaterials for Lightâ€Guided Angiogenesis published pages: 1807734, ISSN: 1616-301X, DOI: 10.1002/adfm.201807734	Advanced Functional Materials 29/6	2020-02-19
2018	Aleeza Farrukh, Wenqiang Fan, Shifang Zhao, Marcelo Salierno, Julieta I. Paez, ArÃ¡nzazu delâ€…Campo Photoactivatable Adhesive Ligands for Light-Guided Neuronal Growth published pages: 1271-1279, ISSN: 1439-4227, DOI: 10.1002/cbic.201800118	ChemBioChem 19/12	2020-02-19
2018	Ernest Latorre, Sohan Kale, Laura Casares, Manuel GÃ³mez-GonzÃ¡lez, Marina Uroz, LÃ©o Valon, Roshna V. Nair, Elena Garreta, Nuria Montserrat, ArÃ¡nzazu del Campo, Benoit Ladoux, Marino Arroyo, Xavier Trepat Active superelasticity in three-dimensional epithelia of controlled shape published pages: 203-208, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0671-4	Nature 563/7730	2020-02-19
2018	Xavier Trepat, Erik Sahai Mesoscale physical principles of collective cell organization published pages: 671-682, ISSN: 1745-2473, DOI: 10.1038/s41567-018-0194-9	Nature Physics 14/7	2020-02-19
2018	Joseph Jose Thottacherry, Anita Joanna Kosmalska, Amit Kumar, Amit Singh Vishen, Alberto Elosegui-Artola, Susav Pradhan, Sumit Sharma, Parvinder P. Singh, Marta C. Guadamillas, Natasha Chaudhary, Ram Vishwakarma, Xavier Trepat, Miguel A. del Pozo, Robert G. Parton, Madan Rao, Pramod Pullarkat, Pere Roca-Cusachs, Satyajit Mayor Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06738-5	Nature Communications 9/1	2020-02-19
2018	Clara R. L. Oudenaarden, Robert A. H. van de Ven, Patrick W. B. Derksen Re-inforcing the cell death army in the fight against breast cancer published pages: jcs212563, ISSN: 0021-9533, DOI: 10.1242/jcs.212563	Journal of Cell Science 131/16	2020-02-19
2018	Arthur J. Kuipers, Jeroen Middelbeek, Kirsten Vrenken, Carlos PÃ©rez-GonzÃ¡lez, Geert Poelmans, Jeffrey Klarenbeek, Kees Jalink, Xavier Trepat, Frank N. van Leeuwen TRPM7 controls mesenchymal features of breast cancer cells by tensional regulation of SOX4 published pages: 2409-2419, ISSN: 0925-4439, DOI: 10.1016/j.bbadis.2018.04.017	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864/7	2020-02-19
2018	Amy E. M. Beedle, Marc Mora, Colin T. Davis, Ambrosius P. Snijders, Guillaume Stirnemann, Sergi Garcia-Manyes Forcing the reversibility of a mechanochemical reaction published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05115-6	Nature Communications 9/1	2020-02-19
2018	Aleeza Farrukh, Shifang Zhao, Julieta I. Paez, Atria Kavyanifar, Marcelo Salierno, Adolfo CavaliÃ©, ArÃ¡nzazu del Campo In Situ, Light-Guided Axon Growth on Biomaterials via Photoactivatable Laminin Peptidomimetic IK(HANBP)VAV published pages: 41129-41137, ISSN: 1944-8244, DOI: 10.1021/acsami.8b15517	ACS Applied Materials & Interfaces 10/48	2020-02-19
2018	Adam Shellard, AndrÃ¡s SzabÃ³, Xavier Trepat, Roberto Mayor Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis published pages: 339-343, ISSN: 0036-8075, DOI: 10.1126/science.aau3301	Science 362/6412	2020-02-19
2018	Marina Uroz, Sabrina Wistorf, Xavier Serra-Picamal, Vito Conte, Marta Sales-Pardo, Pere Roca-Cusachs, Roger GuimerÃ , Xavier Trepat Regulation of cell cycle progression by cellâ€“cell and cellâ€“matrix forces published pages: 646-654, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0107-2	Nature Cell Biology 20/6	2020-02-19
2018	Yong Jian Wang, Palma Rico-Lastres, Ainhoa Lezamiz, Marc Mora, Carles Solsona, Guillaume Stirnemann, Sergi Garcia-Manyes DNA Binding Induces a Nanomechanical Switch in the RRM1 Domain of TDP-43 published pages: 3800-3807, ISSN: 1948-7185, DOI: 10.1021/acs.jpclett.8b01494	The Journal of Physical Chemistry Letters 9/14	2020-02-19
2018	Alberto Elosegui-Artola, Xavier Trepat, Pere Roca-Cusachs Control of Mechanotransduction by Molecular Clutch Dynamics published pages: 356-367, ISSN: 0962-8924, DOI: 10.1016/j.tcb.2018.01.008	Trends in Cell Biology 28/5	2020-02-19
2018	Nils C Gauthier, Pere Roca-Cusachs Mechanosensing at integrin-mediated cellâ€“matrix adhesions: from molecular to integrated mechanisms published pages: 20-26, ISSN: 0955-0674, DOI: 10.1016/j.ceb.2017.12.014	Current Opinion in Cell Biology 50	2020-02-19
2018	Anna Labernadie, Xavier Trepat Sticking, steering, squeezing and shearing: cell movements driven by heterotypic mechanical forces published pages: 57-65, ISSN: 0955-0674, DOI: 10.1016/j.ceb.2018.04.008	Current Opinion in Cell Biology 54	2020-02-19
2017	Pere Roca-Cusachs, Vito Conte, Xavier Trepat Quantifying forces in cell biology published pages: 742-751, ISSN: 1465-7392, DOI: 10.1038/ncb3564	Nature Cell Biology 19/7	2020-02-19
2017	Anna Labernadie, Takuya Kato, AgustÃ BruguÃ©s, Xavier Serra-Picamal, Stefanie Derzsi, Esther Arwert, Anne Weston, Victor GonzÃ¡lez-TarragÃ³, Alberto Elosegui-Artola, Lorenzo Albertazzi, Jordi Alcaraz, Pere Roca-Cusachs, Erik Sahai, Xavier Trepat A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts toÂ drive cancer cell invasion published pages: 224-237, ISSN: 1465-7392, DOI: 10.1038/ncb3478	Nature Cell Biology 19/3	2020-02-19
2017	Alberto Elosegui-Artola, Pere Roca-Cusachs Amoebae as Mechanosensitive Tanks published pages: 2457-2458, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2017.05.020	Biophysical Journal 112/12	2020-02-19
2017	Leire Neri, Marta Lasa, Alberto Elosegui-Artola, Delia D\'Avola, Beatriz Carte, Cristina Gazquez, Sara Alve, Pere Roca-Cusachs, Mercedes IÃ±arrairaegui, Jose Herrero, JesÃºs Prieto, Bruno Sangro, Rafael Aldabe \"NatB-mediated protein N-α-terminal acetylation is a potential therapeutic target in hepatocellular carcinoma\" published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.17332	Oncotarget 8/25	2020-02-19
2018	Mark Bennett, Marco Cantini, Julien Reboud, Jonathan M. Cooper, Pere Roca-Cusachs, Manuel Salmeron-Sanchez Molecular clutch drives cell response to surface viscosity published pages: 1192-1197, ISSN: 0027-8424, DOI: 10.1073/pnas.1710653115	Proceedings of the National Academy of Sciences 115/6	2020-02-19
2017	Roger Oria, Tina Wiegand, Jorge Escribano, Alberto Elosegui-Artola, Juan Jose Uriarte, Cristian Moreno-Pulido, Ilia Platzman, Pietro Delcanale, Lorenzo Albertazzi, Daniel Navajas, Xavier Trepat, JosÃ© Manuel GarcÃa-Aznar, Elisabetta Ada Cavalcanti-Adam, Pere Roca-Cusachs Force loading explains spatial sensing of ligands by cells published pages: , ISSN: 0028-0836, DOI: 10.1038/nature24662	Nature	2020-02-19
2017	Pilar RodrÃguez-Franco, AgustÃ BruguÃ©s, Ariadna MarÃn-LlauradÃ³, Vito Conte, Guiomar Solanas, Eduard Batlle, Jeffrey J. Fredberg, Pere Roca-Cusachs, Raimon Sunyer, Xavier Trepat Long-lived force patterns and deformation waves at repulsive epithelial boundaries published pages: 1029-1037, ISSN: 1476-1122, DOI: 10.1038/NMAT4972	Nature Materials 16/10	2020-02-19
2017	VÃctor GonzÃ¡lez-TarragÃ³, Alberto Elosegui-Artola, Elsa BazelliÃ¨res, Roger Oria, Carlos PÃ©rez-GonzÃ¡lez, Pere Roca-Cusachs Binding of ZO-1 to Î±5Î²1 integrins regulates the mechanical properties of Î±5Î²1â€“fibronectin links published pages: 1847-1852, ISSN: 1059-1524, DOI: 10.1091/mbc.E17-01-0006	Molecular Biology of the Cell 28/14	2020-02-19
2017	Bruno Pontes, Pascale Monzo, Laurent Gole, Anabel-Lise Le Roux, Anita Joanna Kosmalska, Zhi Yang Tam, Weiwei Luo, Sophie Kan, Virgile Viasnoff, Pere Roca-Cusachs, Lisa Tucker-Kellogg, Nils C. Gauthier Membrane tension controls adhesion positioning at the leading edge of cells published pages: jcb.201611117, ISSN: 0021-9525, DOI: 10.1083/jcb.201611117	The Journal of Cell Biology	2020-02-19
2017	Alberto Elosegui-Artola, Ion Andreu, Amy E.M. Beedle, Ainhoa Lezamiz, Marina Uroz, Anita J. Kosmalska, Roger Oria, Jenny Z. Kechagia, Palma Rico-Lastres, Anabel-Lise Le Roux, Catherine M. Shanahan, Xavier Trepat, Daniel Navajas, Sergi Garcia-Manyes, Pere Roca-Cusachs Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores published pages: 1397-1410.e14, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.10.008	Cell 171/6	2020-02-19
2018	Judit Perales-Calvo, David Giganti, Guillaume Stirnemann, Sergi Garcia-Manyes The force-dependent mechanism of DnaK-mediated mechanical folding published pages: eaaq0243, ISSN: 2375-2548, DOI: 10.1126/sciadv.aaq0243	Science Advances 4/2	2020-02-19
2019	Seyedeh Atefeh Mobasseri, Sebastiaan Zijl, Vasiliki Salameti, Gernot Walko, Andrew Stannard, Sergi Garcia-Manyes, Fiona M. Watt Patterning of human epidermal stem cells on undulating elastomer substrates reflects differences in cell stiffness published pages: 256-264, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.01.063	Acta Biomaterialia 87	2020-02-19
2019	Anabel-Lise Le Roux, Xarxa Quiroga, Nikhil Walani, Marino Arroyo, Pere Roca-Cusachs The plasma membrane as a mechanochemical transducer published pages: 20180221, ISSN: 0962-8436, DOI: 10.1098/rstb.2018.0221	Philosophical Transactions of the Royal Society B: Biological Sciences 374/1779	2020-02-19
2019	Jenny Z. Kechagia, Johanna Ivaska, Pere Roca-Cusachs Integrins as biomechanical sensors ofÂ the microenvironment published pages: 457-473, ISSN: 1471-0072, DOI: 10.1038/s41580-019-0134-2	Nature Reviews Molecular Cell Biology 20/8	2020-02-19
2019	Antoine A. Khalil, Johan de Rooij Cadherin mechanotransduction in leader-follower cell specification during collective migration published pages: 86-91, ISSN: 0014-4827, DOI: 10.1016/j.yexcr.2019.01.006	Experimental Cell Research 376/1	2020-02-19
2019	Elvira Infante, Andrew Stannard, Stephanie J. Board, Palma Rico-Lastres, Elena Rostkova, Amy E. M. Beedle, Ainhoa Lezamiz, Yong Jian Wang, Samuel Gulaidi Breen, Fani Panagaki, Vinoth Sundar Rajan, Catherine Shanahan, Pere Roca-Cusachs, Sergi Garcia-Manyes The mechanical stability of proteins regulates their translocation rate into the cell nucleus published pages: , ISSN: 1745-2473, DOI: 10.1038/s41567-019-0551-3	Nature Physics	2020-02-19
2019	Marina Uroz, Anna Garcia-Puig, Isil Tekeli, Alberto Elosegui-Artola, Juan F. Abenza, Ariadna MarÃn-LlauradÃ³, Silvia Pujals, Vito Conte, Lorenzo Albertazzi, Pere Roca-Cusachs, Ãngel Raya, Xavier Trepat Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium published pages: , ISSN: 1476-1122, DOI: 10.1038/s41563-019-0381-9	Nature Materials	2020-02-19
2019	Elena Garreta, Patricia Prado, Carolina Tarantino, Roger Oria, Lucia Fanlo, Elisa MartÃ, Dobryna Zalvidea, Xavier Trepat, Pere Roca-Cusachs, Aleix GavaldÃ -Navarro, Luca Cozzuto, Josep M. Campistol, Juan Carlos IzpisÃºa Belmonte, Carmen Hurtado del Pozo, Nuria Montserrat Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells published pages: 397-405, ISSN: 1476-1122, DOI: 10.1038/s41563-019-0287-6	Nature Materials 18/4	2020-02-19
2019	Essak S. Khan, Shrikrishnan Sankaran, Julieta I. Paez, Christina Muth, Mitchell K. L. Han, ArÃ¡nzazu del Campo Photoactivatable Hsp47: A Tool to Regulate Collagen Secretion and Assembly published pages: 1801982, ISSN: 2198-3844, DOI: 10.1002/advs.201801982	Advanced Science 6/9	2020-02-19

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