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BIO-CAPTURE

Biomechanical Characterization of Carotid Plaque Rupture

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BIO-CAPTURE project word cloud

Explore the words cloud of the BIO-CAPTURE project. It provides you a very rough idea of what is the project "BIO-CAPTURE" about.

technique inverse predictive distributions finite histology morbidity surgery besides carotid plaques stress mortality material compute events skill atherosclerotic removal models worldwide enhancement aid fingerprints human triggered exists return first prevent fundamental cutting edge decisions ultrasound surgical missing plaque strain vivo data physiological pathomorphology stroke treatment made tools arteries experimental inflation descriptors valuable risk computational biomechanical collected training biomechanics accurate experimentation combining examination artery modeling fe heterogeneous fellowship clinical environment tests assessing ex expertise rupture 3d back tissue imaging frequency

Project "BIO-CAPTURE" data sheet

The following table provides information about the project.

Coordinator	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.aliakyildiz.net
Total cost	165˙598 €
EC max contribution	165˙598 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-RI
Starting year	2017
Duration (year-month-day)	from 2017-07-01 to 2019-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	coordinator	165˙598.00

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Project objective

Stroke is the second leading cause of mortality worldwide. Most stroke events are triggered by an atherosclerotic plaque rupture in a carotid artery. Current clinical decisions for the carotid plaque removal surgery are made without assessing the plaque rupture risk as no reliable means exists today. Biomechanics can help to develop such risk assessment tools; yet, the fundamental knowledge on biomechanical descriptors of plaque rupture is missing. This project aims to provide biomechanical characteristics of atherosclerotic plaque rupture. This will be done by combining experimental work, high-end plaque imaging and computational modeling. First, non-existing biomechanical plaque rupture data will be collected from a novel experimental approach of physiological, ex-vivo inflation/rupture tests with atherosclerotic human carotid arteries. The pre-rupture and rupture strain distributions in plaques during the tests will be assessed in 3D via a cutting-edge high frequency ultrasound technique. With a novel inverse finite element (FE) technique, heterogeneous material properties of the plaques will be identified. This unique material information will be used in plaque-specific FE models to compute 3D pre-rupture and rupture stress distributions in the plaques. The assessed plaque strain and stress fingerprints will be evaluated for their predictive value of plaque rupture. The essential knowledge on biomechanical characteristics of plaque rupture will aid making more accurate surgical treatment decisions to prevent stroke-related mortality and morbidity. Besides the high-impact research, this fellowship will also result in enhancement of the applicant’s skill set through the valuable training on ultrasound imaging, histology and pathomorphology examination. Furthermore, the fellowship will allow him to return to the EU research environment, and bring back his expertise in tissue experimentation and modeling, and advanced FE analysis.

Publications

List of publications.
year	authors and title	journal	last update
2017	Ali C. Akyildiz, Lambert Speelman, Bas van Velzen, Raoul R. F. Stevens, Antonius F. W. van der Steen, Wouter Huberts, Frank J. H. Gijsen Intima heterogeneity in stress assessment of atherosclerotic plaques published pages: 20170008, ISSN: 2042-8898, DOI: 10.1098/rsfs.2017.0008	Interface Focus 8/1	2019-10-10
2017	Ali C. Akyildiz, Chen-Ket Chai, Cees W.J. Oomens, Aad van der Lugt, Frank P.T. Baaijens, Gustav J. Strijkers, Frank J.H. Gijsen 3D Fiber Orientation in Atherosclerotic Carotid Plaques published pages: 28-35, ISSN: 1047-8477, DOI: 10.1016/j.jsb.2017.08.003	Journal of Structural Biology 200/1	2019-10-10
2019	Hilary E. Barrett, Kim Van der Heiden, Eric Farrell, Frank J.H. Gijsen, Ali C. Akyildiz Calcifications in atherosclerotic plaques and impact on plaque biomechanics published pages: 1-12, ISSN: 0021-9290, DOI: 10.1016/j.jbiomech.2019.03.005	Journal of Biomechanics 87	2019-10-10

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The information about "BIO-CAPTURE" are provided by the European Opendata Portal: CORDIS opendata.