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FocAd SIGNED

Structural Studies on Focal Adhesions

Total Cost €

0

EC-Contrib. €

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Partnership

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 FocAd project word cloud

Explore the words cloud of the FocAd project. It provides you a very rough idea of what is the project "FocAd" about.

employ    integrin    clarified    expertise    implicated    systematic    adhesions    regulation    complexes    defects    leads    hence    governing    light    emerged    focal    ligand    aggressive    techniques    combination    detrimental    migration    machinery    activation    protein    innovative    biophysical    living    behavior    networks    purified    molecular    ultrastructural    outside    recombinant    cancers    assembly    gigantic    fashion    microscopy    tackle    membranes    sensitive    cell    transferred    macromolecular    cryo    cells    edge    regarding    polarization    basis    cytoskeleton    counteracting    triggered    tension    fundamental    contributes    environment    developmental    unclear    platform    initiating    survival    ray    sophisticated    fa    players    sensing    mass    crystallography    mechanisms    transduce    components    function    fas    actin    signaling    biochemical    observe    tested    lessons    hybrid    force    structural    points    spectrometry    core    em    stepwise    reconstitutions    hierarchical    assemblies    cytoskeletons    cutting    biology    questions    super    medically    learned    anchoring   

Project "FocAd" data sheet

The following table provides information about the project.

Coordinator		 MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Total cost 1˙999˙998 €
 EC max contribution 1˙999˙998 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 1˙999˙998.00

Map

 Project objective

Focal adhesions (FA) are gigantic protein complexes whose formation is triggered by integrin ligand activation. FAs represent (1) a sensing platform and anchoring points to the outside environment and, (2) a machinery to transduce this information by initiating signaling pathways for cell growth, survival, migration and polarization. Failure in the regulation of FA leads to developmental defects and contributes to the formation of aggressive cancers. Hence, understanding FA formation is the basis for counteracting these detrimental effects. Recently, mass spectrometry and advanced light microscopy clarified players involved in the FA assembly and implicated sophisticated regulation networks of membranes and actin cytoskeletons in the growth of FAs. However, the molecular mechanisms of FA formation and signaling still remain unclear. We propose to study the molecular mechanisms governing the growth of FA by bottom-up reconstitutions using purified recombinant protein components. We will employ a systematic and hierarchical assembly of the FA machinery on an integrin platform as well as on an actin cytoskeleton in a stepwise fashion. We will use a combination of cutting-edge techniques of hybrid structural biology (cryo-EM and X-ray crystallography), light microscopy and biochemical/biophysical approaches. Our core expertise is cryo-EM, which has emerged as the method of choice to study the molecular mechanisms of (super-)macromolecular assemblies. Furthermore, we will set up a system to observe the behavior of tension-sensitive FA components in the presence of force under cryo-EM. Finally, lessons learned from our biochemical and ultrastructural analysis will be directly transferred and tested in living cells. Using these innovative methods, we will tackle fundamental and medically relevant questions regarding the assembly and function of FAs.

 Publications

year authors and title journal last update
List of publications.
2019 Dirk Dedden, Stephanie Schumacher, Charlotte F. Kelley, Martin Zacharias, Christian Biertümpfel, Reinhard Fässler, Naoko Mizuno
The Architecture of Talin1 Reveals an Autoinhibition Mechanism
published pages: 120-131.e13, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.08.034 		Cell 179/1 2019-12-17

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