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BigData Heart SIGNED

Big Data 4 Better Hearts - Sofia ref.: 116074

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

BigData Heart project word cloud

Explore the words cloud of the BigData Heart project. It provides you a very rough idea of what is the project "BigData Heart" about.

syndrome unparalleled progress expenditures renders poor variations unmet medication prognoses scalable proven post markers regard hence hf hospitalisations pipelines ultimate treatments driving outcomes translational endpoint resolution healthcare underlying category global groups approval eventual acs platform expensive acknowledging small world life coronary diseases mechanisms cvd complicated drug scientific endpoints trials aetiology slow validation limited death heterogeneous lowest oncology chance bigdata clinical phenotypes adherence damage remarkable guide functional morbidities earlier candidate 7 tolerability cardiovascular af marketing clinically mortality form burden unpredictable fibrillation era risk guidelines segmentation capacity big conventional individual insights patients therapy phenotypic shared molecular data acute treatment definition optimal components comorbidities constraints inter disease co qol quality undetectable heart organ reflect despite patient atrial unselected variation productivity

Project "BigData Heart" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	https://www.bigdata-heart.eu/
Total cost	19˙398˙970 €
EC max contribution	9˙664˙970 € (50%)
Programme	1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
Code Call	H2020-JTI-IMI2-2015-07-two-stage
Funding Scheme	IMI2-RIA
Starting year	2017
Duration (year-month-day)	from 2017-03-01 to 2022-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	coordinator	4˙047˙075.00
2	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	1˙136˙250.00
3	CHARITE - UNIVERSITAETSMEDIZIN BERLIN CHARITE - UNIVERSITAETSMEDIZIN BERLIN Organization address address: Chariteplatz 1 city: BERLIN postcode: 10117 website: www.charite.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	929˙375.00
4	SOCIETE EUROPEENNE DE CARDIOLOGIE SOCIETE EUROPEENNE DE CARDIOLOGIE Organization address address: ROUTE DES COLLES 2035 city: BIOT SOPHIA ANTIPOLIS postcode: 6903 website: www.escardio.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (BIOT SOPHIA ANTIPOLIS)	participant	874˙688.00
5	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	391˙845.00
6	FUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNITAT VALENCIANA, FUNDACION INCLIVA FUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNITAT VALENCIANA, FUNDACION INCLIVA Organization address address: AV MENENDEZ PELAYO 4 city: VALENCIA postcode: 46010 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VALENCIA)	participant	386˙250.00
7	UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF Organization address address: Martinistrasse 52 city: HAMBURG postcode: 20251 website: www.uke.uni-hamburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HAMBURG)	participant	386˙250.00
8	THE HYVE BV THE HYVE BV Organization address address: ARTHUR VAN SCHENDELSTRAAT 650 city: UTRECHT postcode: 3511 MJ website: www.thehyve.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	326˙250.00
9	INTERNATIONAL CONSORTIUM FOR HEALTHOUTCOMES MEASUREMENT INC. INTERNATIONAL CONSORTIUM FOR HEALTHOUTCOMES MEASUREMENT INC. Organization address address: 14 ARROW STREET SUITE 11 city: CAMBRIDGE MA postcode: 2215 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (CAMBRIDGE MA)	participant	319˙375.00
10	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	200˙000.00
11	THE UNIVERSITY OF BIRMINGHAM THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	participant	200˙000.00
12	UPPSALA UNIVERSITET UPPSALA UNIVERSITET Organization address address: VON KRAEMERS ALLE 4 city: UPPSALA postcode: 751 05 website: www.uu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UPPSALA)	participant	200˙000.00
13	EUROPEAN HEART NETWORK AISBL EUROPEAN HEART NETWORK AISBL Organization address address: RUE MONTOYER 31 city: BRUXELLES postcode: 1000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	150˙800.00
14	STICHTING MLC FOUNDATION STICHTING MLC FOUNDATION Organization address address: DAGELIJSKE GROENMARKT 2 city: DEN HAAG postcode: 2513 AL website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DEN HAAG)	participant	116˙812.00
15	BAYER AKTIENGESELLSCHAFT BAYER AKTIENGESELLSCHAFT Organization address address: KAISER-WILHEM-ALLEE 1 city: Leverkusen postcode: 51373 website: http://pharma.bayer.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Leverkusen)	participant	0.00
16	INSTITUT DE RECHERCHES INTERNATIONALES SERVIER INSTITUT DE RECHERCHES INTERNATIONALES SERVIER Organization address address: RUE CARNOT 50 city: SURESNES postcode: 92284 website: www.servier.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (SURESNES)	participant	0.00
17	NOVARTIS PHARMA AG NOVARTIS PHARMA AG Organization address address: LICHTSTRASSE 35 city: BASEL postcode: 4056 website: www.novartis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	0.00
18	SOMALOGIC INC SOMALOGIC INC Organization address address: WILDERNESS PLACE 2945 city: BOULDER COLORADO postcode: 80301 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (BOULDER COLORADO)	participant	0.00
19	VIFOR (INTERNATIONAL) AG VIFOR (INTERNATIONAL) AG Organization address address: RECHENSTRASSE 37 city: ST GALLEN postcode: 9014 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ST GALLEN)	participant	0.00

Map

Project objective

Despite remarkable progress in the management of cardiovascular disease (CVD), major unmet needs remain with regard to mortality, hospitalisations, quality of life (QoL), healthcare expenditures and productivity. Acute coronary syndrome (ACS), atrial fibrillation (AF) and heart failure (HF) are major and growing components of the global CVD burden. Optimal management of these conditions is complicated by their complex aetiology and heterogeneous prognoses. Poor definition at the molecular level and co/multi-morbidities form major challenges for the development and delivery of targeted treatments. This renders response to therapy unpredictable, with large inter-individual variation and, importantly, small or undetectable treatment effects in large trials of unselected patients.

Today’s treatment guidelines still reflect the scientific constraints of an earlier era where clinical markers to guide therapy are limited to conventional risk factors and end-organ damage, and where the main endpoint in clinical trials is patient death. Hence, drug development pipelines from early target validation through to late post-marketing work have proven to be slow, expensive and high-risk: the chance of eventual approval for a CVD drug candidate in Phase I trials is 7%, the lowest of any disease category (shared with oncology) 2. Moreover, tolerability of medication and adherence to treatment show wide variations. There is thus a need for better definition of these diseases, their markers and endpoints (including better segmentation of current heterogeneous patient groups acknowledging underlying mechanisms and comorbidities) and of their outcomes/prognoses (including functional capacity and quality of life [QoL]).

BigData@Heart’s ultimate goal is to develop a Big Data--driven translational research platform of unparalleled scale and phenotypic resolution in order to deliver clinically relevant disease phenotypes, scalable insights from real-world evidence and insights driving

Deliverables

List of deliverables.
Report on basic model for datasharing and â€“access, data mapping, curating and analysis within the consortium	Documents, reports	2020-04-09 01:08:50
Data management plan	Documents, reports	2020-04-09 01:08:49
Minutes of annual meetings	Documents, reports	2020-04-09 01:08:50
Open access catalogue detailing the available datasets and associated variables in the consortium	Documents, reports	2020-04-09 01:08:49
Periodic reports on advice on legal, ethical and governance issues by the Governance Committee	Documents, reports	2020-04-09 01:08:49
First version of the remote monitoring platform, based on RADAR-CNS platform and deployed on Android and iOS, for capturing data for running studies in the consortium	Websites, patent fillings, videos etc.	2020-04-09 01:08:49
Annual reports, including an Ethic Report of the external Ethics Advisor	Documents, reports	2020-04-09 01:08:49
Detailed project plan, plus tracking tools, to be maintained throughout the life of the project	Documents, reports	2020-04-09 01:08:49
Public website	Websites, patent fillings, videos etc.	2020-04-09 01:08:49
Minutes of kick-off	Documents, reports	2020-04-09 01:08:49
Document detailing distinct project image, including logo and templates for presentations	Documents, reports	2020-04-09 01:08:49
Exploitation plan and periodic updates	Documents, reports	2020-04-09 01:08:49
Project management plans	Documents, reports	2020-04-09 01:08:49
Communication and dissemination plan and periodic updates	Documents, reports	2020-04-09 01:08:49
Report of evaluation of enrichment strategies with recommendations	Documents, reports	2020-04-09 01:08:49
Collaborative website (intranet)	Websites, patent fillings, videos etc.	2020-04-09 01:08:49
Contact database (stakeholders and key project contacts)	Documents, reports	2020-04-09 01:08:49

Take a look to the deliverables list in detail: detailed list of BigData Heart deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Shona Kalkman, Menno Mostert, Christoph Gerlinger, Johannes J. M. van Delden, Ghislaine J. M. W. van Thiel Responsible data sharing in international health research: a systematic review of principles and norms published pages: , ISSN: 1472-6939, DOI: 10.1186/s12910-019-0359-9	BMC Medical Ethics 20/1	2020-04-09
2019	Alicia Uijl, Stefan Koudstaal, Kenan Direk, Spiros Denaxas, Rolf H. H. Groenwold, Amitava Banerjee, Arno W. Hoes, Harry Hemingway, Folkert W. Asselbergs Risk factors for incident heart failure in age- and sex-specific strata: a population-based cohort using linked electronic health records published pages: , ISSN: 1388-9842, DOI: 10.1002/ejhf.1350	European Journal of Heart Failure	2020-04-09
2018	Sander W van der Laan, Eric L Harshfield, Daiane Hemerich, David Stacey, Angela M Wood, Folkert W Asselbergs From lipid locus to drug target through human genomics published pages: , ISSN: 0008-6363, DOI: 10.1093/cvr/cvy120	Cardiovascular Research	2020-04-09
2017	Harry Hemingway, Folkert W Asselbergs, John Danesh, Richard Dobson, Nikolaos Maniadakis, Aldo Maggioni, Ghislaine JM van Thiel, Maureen Cronin, Gunnar Brobert, Panos Vardas, Stefan D Anker, Diederick E Grobbee, Spiros Denaxas, Diederick E Grobbee, Folkert Asselbergs, Arno Hoes, Ghislaine van Thiel, Hans van Delden, RenÃ© Eijkemans, Rolf Groenwold, Pieter Stolk, Olaf Klungel, Stefan D Anker, Gerd P Hasenfuss, Stephan von Haehling, Panos Vardas, Aldo Maggioni, Gerhard Hindricks, Nikolaos Maniadakis, John Camm, Isabel Bardinet, Christina Dimopoulou, Susanne LÃ¸gstrup, Harry Hemingway, Richard Dobson, Aroon Hingorani, Spiros Denaxas, Folkert Asselbergs, JP Casas, Amitava Banerjee, Bernard de Bono, Tom Lumbers, Dan Swerdlow, Riyaz Patel, Claudia Langenberg, John Danesh, Adam Butterworth, Angela Wood, Jason Arora, Josep Redon, FJ Chorro, Juan Carlos PÃ©rez CortÃ©s, J Sanchis, J NuÃ±ez, V Bodi, F Martinez, Daniel Saez-Domingo, Jose L Trillo, Lina Badimon, Tomas Jernberg, Henrik Olsson, Jonas FaxÃ©n, Tonje Thorvaldsen, Lars H Lund, Gianluigi Savarese, Stefan James, Bodil Svennblead, Stefan Blankenberg, Tanja Zeller, Renate Schnabel, Evert Ben van Veen, Paulus Kirchhof, Dipak Kotecha, Bodil Svennblead, Stefan James, Jonas Oldgren, Andrea Bayer, Gunnar Brobert, Tomasz Dyszynski, Christoph Gerlinger, Daniel Freitag, John Edward Butler-Ransohoff, Alex Asiimwe, Alexander Michel, Kiliana Suzart-Woischnik, Sebastian Kloss, Frederico Calado, Anders Gabrielsen, Vanessa Blanc, Nicolas Boisseau, Fabrice Couvelard, Willy Gosgnach, Olivier Gryson, Julien Hervouet, Weiwei Li-Bertheau, BenoÃ®t Tyl, Jessica Williams, Jessica Ash, Steve Williams, Rachel Ostroff, Alan Williams, Maureen Cronin, Vincent Fabian, Ong Siew Hwa, Avi Leaf, Kees van Bochove, Marinel Cavelaars, Maxim Moinat, Stefan Payralbe Big data from electronic health records for early and late translational cardiovascular research: challenges and potential published pages: , ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehx487	European Heart Journal	2020-04-09
2017	Stefan Anker, Folkert Wouter Asselbergs, Gunnar Brobert, Panos Vardas, Diederick E Grobbee, Maureen Cronin Big Data in Cardiovascular Disease published pages: 1863-1865, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehx283	European Heart Journal 38/24	2020-04-09

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BIGDATA HEART" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "BIGDATA HEART" are provided by the European Opendata Portal: CORDIS opendata.

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