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TRIBAL SIGNED

A TRranslational approach to Identify Biomarkers for Asthma and Lung function impairment

Total Cost €

EC-Contrib. €

Partnership

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TRIBAL project word cloud

Explore the words cloud of the TRIBAL project. It provides you a very rough idea of what is the project "TRIBAL" about.

globally origin impairment biomarkers phenotyping persistence people cohort progression lung deep million 2017 089 wheezing treatment efforts exposure adulthood adults airways starting pulmonary nitrogen disease preventive immune 20s capitalize samples bamse 24 repeated tests longitudinal childhood innate obstructive 300 explored asthma time birth curative washout breathlessness describing monitor function predict data young characterization point children life accurately bio swedish inflammatory sampling risk relation setup drugs diseases cells symptoms tribal patients cell respiratory adult initiated population mechanisms ultimate stage persistent copd gene chronic world bronchodilator molecular follow protein

Project "TRIBAL" data sheet

The following table provides information about the project.

Coordinator	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Total cost	1˙500˙000 €
EC max contribution	1˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-STG
Funding Scheme	ERC-STG
Starting year	2017
Duration (year-month-day)	from 2017-12-01 to 2022-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	coordinator	1˙500˙000.00

Map

Project objective

Asthma is a chronic inflammatory disease of the airways that cause symptoms like wheezing and breathlessness. In children, asthma is the most common chronic disease and according to the WHO, more than 300 million people are affected globally. There is no curative treatment available. Persistence of childhood asthma into adult life is associated with lung function impairment and increased risk of chronic obstructive pulmonary disease, COPD. Evidence is now emerging that adult diseases, like COPD, may have their origin early in life. However, there are no established biomarkers that can accurately monitor asthma progression or predict development of COPD in adults. In this TRIBAL project, I will capitalize on rich longitudinal data and repeated bio-sampling from the Swedish BAMSE study, a world-leading population-based birth cohort of 4,089 participants with a new 24-year follow-up starting in 2017. A key aim with the new follow-up is to identify young adults in their 20s with persistent asthma and pre-stage COPD by advanced lung function assessment that includes bronchodilator and nitrogen washout tests. In TRIBAL, the unique setup is deep phenotyping of these patients describing different aspects of the respiratory system, as well as molecular characteristics of relevant bio-samples and cells. Disease-related biomarkers and involved mechanisms, from gene to protein, will be identified from early childhood to adulthood. Both the innate and the adapted immune system with detailed cell characterization will be explored in relation to exposure and disease development. Specifically, with this novel approach I will address the time point during childhood when disease processes related to persistent asthma and pre-stage COPD were initiated. The ultimate goal in TRIBAL is to provide new knowledge for targeted preventive efforts in children at risk of adult chronic lung disease, and to identify potential targets for new asthma and COPD drugs.

Publications

List of publications.
year	authors and title	journal	last update
2020	Simon Kebede Merid, Alexei Novoloaca, Gemma C. Sharp, Leanne K. KÃ¼pers, Alvin T. Kho, Ritu Roy, Lu Gao, Isabella Annesi-Maesano, Pooja Jain, Michelle Plusquin, Manolis Kogevinas, Catherine Allard, Florianne O. Vehmeijer, Nabila Kazmi, Lucas A. Salas, Faisal I. Rezwan, Hongmei Zhang, Sylvain Sebert, Darina Czamara, Sheryl L. Rifas-Shiman, Phillip E. Melton, Debbie A. Lawlor, GÃ¶ran Pershagen, Carr Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age published pages: , ISSN: 1756-994X, DOI: 10.1186/s13073-020-0716-9	Genome Medicine 12/1	2020-03-23
2020	Korneliusz Golebski, Michael Kabesch, Erik MelÃ©n, UroÅ¡ PotoÄnik, Cornelis M. van Drunen, Susanne Reinarts, Anke H. Maitland-van der Zee, Susanne J.H. Vijverberg Childhood asthma in the new omics era published pages: 155-161, ISSN: 1528-4050, DOI: 10.1097/aci.0000000000000626	Current Opinion in Allergy and Clinical Immunology 20/2	2020-03-23
2020	Emmanouela Sdona, Jenny Hallberg, Niklas Andersson, Sandra EkstrÃ¶m, Susanne Rautiainen, Niclas HÃ¥kansson, Alicja Wolk, Inger Kull, Erik MelÃ©n, Anna BergstrÃ¶m Dietary antioxidant intake in school age and lung function development up to adolescence published pages: 1900990, ISSN: 0903-1936, DOI: 10.1183/13993003.00990-2019	European Respiratory Journal 55/2	2020-03-23
2018	Erik MelÃ©n, Robert Barouki, Maeve Barry, H. Marike Boezen, Barbara Hoffmann, Susanne Krauss-Etschmann, GerardÂ H. Koppelman, Bertil Forsberg Promoting respiratory public health through epigenetics research: an ERS Environment Health Committee workshop report published pages: 1702410, ISSN: 0903-1936, DOI: 10.1183/13993003.02410-2017	European Respiratory Journal 51/4	2019-06-11
2018	Cheng-Jian Xu, Cilla SÃ¶derhÃ¤ll, Mariona Bustamante, Nour BaÃ¯z, Olena Gruzieva, Ulrike Gehring, Dan Mason, Leda Chatzi, Mikel Basterrechea, Sabrina Llop, Maties Torrent, Francesco Forastiere, Maria Pia Fantini, Karin C LÃ¸drup Carlsen, Tari Haahtela, AndrÃ©anne Morin, Marjan Kerkhof, Simon Kebede Merid, Bianca van Rijkom, Soesma A Jankipersadsing, Marc Jan Bonder, Stephane Ballereau, Cornelis J Vermeulen, Raul Aguirre-Gamboa, Johan C de Jongste, Henriette A Smit, Ashish Kumar, GÃ¶ran Pershagen, Stefano Guerra, Judith Garcia-Aymerich, Dario Greco, Lovisa Reinius, Rosemary R C McEachan, Raf Azad, Vegard Hovland, Petter Mowinckel, Harri Alenius, Nanna Fyhrquist, NathanaÃ«l Lemonnier, Johann Pellet, Charles Auffray, Pieter van der Vlies, Cleo C van Diemen, Yang Li, Cisca Wijmenga, Mihai G Netea, Miriam F Moffatt, William O C M Cookson, Josep M Anto, Jean Bousquet, Tiina Laatikainen, Catherine Laprise, Kai-HÃ¥kon Carlsen, Davide Gori, Daniela Porta, Carmen IÃ±iguez, Jose Ramon Bilbao, Manolis Kogevinas, John Wright, Bert Brunekreef, Juha Kere, Martijn C Nawijn, Isabella Annesi-Maesano, Jordi Sunyer, Erik MelÃ©n, Gerard H Koppelman DNA methylation in childhood asthma: an epigenome-wide meta-analysis published pages: , ISSN: 2213-2600, DOI: 10.1016/S2213-2600(18)30052-3	The Lancet Respiratory Medicine	2019-06-11

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The information about "TRIBAL" are provided by the European Opendata Portal: CORDIS opendata.