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MicroWars SIGNED

The Evolution of Bacterial Warfare

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MicroWars project word cloud

Explore the words cloud of the MicroWars project. It provides you a very rough idea of what is the project "MicroWars" about.

perspective    behaviours    extreme    watched    game    spears    electron    bacterial    warfare    asking    why    competitive    tactics    coli    communities    animal    group    assemble    complexity    animals    launch    employ    techniques    weapons    cells    competitors    aeruginosa    levels    risk    genomics    battlegrounds    image    co    attack    commit    predictions    pseudomonas    freestyle    stab    edge    punch    combining    evolve    influence    confocal    simply    poisoned    evolution    extremely    release    fight    microbiome    protein    experimental    species    experiments    weaponry    genetics    germ    cryomicroscopy    meet    escherichia    evolutionary    clear    molecular    aggression    combat    host    mouse    suicide    neighbours    ecology    combination    fluorescence    examine    biology    first    microfluidics    questions    microscopy    bacteria    holes    individual    many    mammalian    proven    cutting    machines    position    possess    model    ecological    literature    theory    generally    competition    reluctant    time    intense    aggressive    free   

Project "MicroWars" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙750˙137 €
 EC max contribution 2˙750˙137 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 2˙750˙137.00

Map

 Project objective

Many bacteria are extremely aggressive. They assemble poisoned molecular spears to stab neighbours, they release protein machines that punch holes in competitors and, moreover, some cells will commit suicide in order to launch their attack. While there is a large literature on the evolution of combat and competition in animals, this has focused on why animals are generally reluctant to fight. The evolution of extreme aggression in bacteria, therefore, challenges our current understanding of competition in biology. I will develop bacterial warfare as a model for competitive behaviour by asking three key questions that each build in complexity: 1) Why do weapons evolve? 2) What tactics do bacteria use during combat and why? 3) How does ecological complexity influence the value and use of weapons? My group will examine these questions theoretically and test our predictions using two model species, Escherichia coli and Pseudomonas aeruginosa, which possess very different levels of weaponry. The project has risk and challenges in that bacterial behaviours cannot simply be watched like animal behaviours. To meet these, we will employ a proven combination of individual-based modelling, game theory, competition experiments, experimental evolution, confocal microscopy, molecular genetics, genomics and germ-free mouse work. We will also co-develop new techniques. Freestyle microfluidics will position bacteria and weaponry for study; electron fluorescence cryomicroscopy will image, for the first time, bacterial battlegrounds at the molecular scale. By combining cutting-edge methods with clear evolutionary questions, I aim to provide a major new perspective on combat, and on bacteria. There is currently an intense interest in how bacteria establish in host-associated communities, including the mammalian microbiome. Understanding this will need a new focus on the evolution, and ecology, of bacterial warfare.

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The information about "MICROWARS" are provided by the European Opendata Portal: CORDIS opendata.

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