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MicroWars SIGNED

The Evolution of Bacterial Warfare

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MicroWars project word cloud

Explore the words cloud of the MicroWars project. It provides you a very rough idea of what is the project "MicroWars" about.

combining    aggressive    extreme    model    image    risk    germ    competition    genomics    generally    perspective    combination    evolve    co    animals    reluctant    evolution    behaviours    machines    complexity    fight    microbiome    communities    theory    attack    first    clear    biology    evolutionary    extremely    warfare    aeruginosa    watched    mouse    fluorescence    ecology    release    experimental    proven    possess    weapons    animal    cells    commit    holes    competitors    many    asking    ecological    microscopy    tactics    edge    punch    stab    why    suicide    pseudomonas    confocal    weaponry    neighbours    protein    individual    examine    intense    predictions    experiments    techniques    molecular    poisoned    coli    species    game    combat    questions    employ    bacteria    time    free    bacterial    microfluidics    electron    launch    host    levels    aggression    influence    assemble    escherichia    cutting    freestyle    cryomicroscopy    group    competitive    simply    meet    battlegrounds    position    spears    genetics    mammalian    literature   

Project "MicroWars" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙750˙137 €
 EC max contribution 2˙750˙137 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 2˙750˙137.00

Map

 Project objective

Many bacteria are extremely aggressive. They assemble poisoned molecular spears to stab neighbours, they release protein machines that punch holes in competitors and, moreover, some cells will commit suicide in order to launch their attack. While there is a large literature on the evolution of combat and competition in animals, this has focused on why animals are generally reluctant to fight. The evolution of extreme aggression in bacteria, therefore, challenges our current understanding of competition in biology. I will develop bacterial warfare as a model for competitive behaviour by asking three key questions that each build in complexity: 1) Why do weapons evolve? 2) What tactics do bacteria use during combat and why? 3) How does ecological complexity influence the value and use of weapons? My group will examine these questions theoretically and test our predictions using two model species, Escherichia coli and Pseudomonas aeruginosa, which possess very different levels of weaponry. The project has risk and challenges in that bacterial behaviours cannot simply be watched like animal behaviours. To meet these, we will employ a proven combination of individual-based modelling, game theory, competition experiments, experimental evolution, confocal microscopy, molecular genetics, genomics and germ-free mouse work. We will also co-develop new techniques. Freestyle microfluidics will position bacteria and weaponry for study; electron fluorescence cryomicroscopy will image, for the first time, bacterial battlegrounds at the molecular scale. By combining cutting-edge methods with clear evolutionary questions, I aim to provide a major new perspective on combat, and on bacteria. There is currently an intense interest in how bacteria establish in host-associated communities, including the mammalian microbiome. Understanding this will need a new focus on the evolution, and ecology, of bacterial warfare.

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The information about "MICROWARS" are provided by the European Opendata Portal: CORDIS opendata.

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