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Achilles SIGNED

Overcoming specific weaknesses in tendon biology to design advanced regenerative therapies

Total Cost €

EC-Contrib. €

Partnership

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Achilles project word cloud

Explore the words cloud of the Achilles project. It provides you a very rough idea of what is the project "Achilles" about.

shows modular biophysics medicine organization regensburg minho developmental competitiveness treatment trauma therapies center treat establishing genetics profile tine complemented science outstanding sustainability disorders kur network cell achilles continue intellectual laboratory translation engineering create links molecular therapy uminho sharing galway strategies ireland human sustained compete scientific gene twinning 3b property translate visibility unleash regenerative group significantly diseases medical excellence nuig staff clinic constant generating centre services tendon sustainably rehabilitation reinforce gaps national networking excellent consulting strengthen injuries positioning tissue surgery biology global capacity mayo university internationally capability quality therapeutic international

Project "Achilles" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDADE DO MINHO Organization address address: LARGO DO PACO city: BRAGA postcode: 4704 553 website: www.uminho.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Total cost	999˙626 €
EC max contribution	999˙626 € (100%)
Programme	1. H2020-EU.4.b. (Twinning of research institutions)
Code Call	H2020-WIDESPREAD-05-2017-Twinning
Funding Scheme	CSA
Starting year	2018
Duration (year-month-day)	from 2018-10-01 to 2021-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDADE DO MINHO UNIVERSIDADE DO MINHO Organization address address: LARGO DO PACO city: BRAGA postcode: 4704 553 website: www.uminho.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (BRAGA)	coordinator	500˙601.00
2	KLINIKUM DER UNIVERSITAET REGENSBURG KLINIKUM DER UNIVERSITAET REGENSBURG Organization address address: FRANS JOSEF STRAUSS ALLEE 11 city: REGENSBURG postcode: 93053 website: www-cgi.uni-regensburg.de/Klinik/Klinikum/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (REGENSBURG)	participant	249˙512.00
3	NATIONAL UNIVERSITY OF IRELAND GALWAY NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Galway)	participant	249˙512.00

Map

Project objective

The main goal of Achilles is to significantly strengthen the science and technology capacity of UMinho in biophysics, cell/molecular biology and genetics/gene therapy in order to achieve global scientific excellence and competitiveness for the translation of advanced therapies/ tendon tissue engineering strategies to treat tendon injuries/diseases; At the same tine, Achilles also aims at positioning the research profile of UMinho and its staff in an outstanding international research level. This will be achieved by establishing a twinning process through knowledge sharing and collaboration between 3B’s Research Group of University of Minho (UMinho) and 3 internationally leading institutions: Department of Trauma Surgery of the University Regensburg Medical Centre (KUR), the Regenerative, Modular & Developmental Engineering Laboratory of the National University of Ireland Galway (NUIG) and the Rehabilitation Medicine Research Center of Mayo Clinic (MAYO). Achilles will focus in defined areas in which UMinho shows a less scientific knowledge and are well-complemented by KUR/NUIG/MAYO.â€¨The project objectives are: - To significantly increase the scientific excellence in tendon tissue engineering and reinforce human resources profile of UMinho; - To significantly increase the international visibility of UMinho and unleash its networking gaps with international outstanding R&D organisations; - To create strong links between UMinho-KUR-NUIG-Mayo allowing a constant and sustained knowledge sharing and research collaboration network which will continue sustainably in the long-term; - To significantly increase the capacity of UMinho to translate excellent scientific production into new therapeutic approaches for the treatment of tendon disorders and in providing high-quality services and consulting, improved capability to compete for funding as well as generating useful intellectual property that can help to support in the long-term the sustainability of the organization.

Publications

List of publications.
year	authors and title	journal	last update
2020	Prof. Dr. Denitsa Docheva (Guest Editor) Special issue â€œAchilles Curse and Remedy: Tendon Diseases from Pathophysiology to Novel Therapeutic Approachesâ€ published pages: , ISSN: 1422-0067, DOI:	International Journal of Molecular Sciences	2020-04-15
2018	S. Ribeiro, V. Novacek, E.M. Fernandes, M.E. Gomes, R.L. Reis, Y. Bayon, D.I. Zeugolis DESIGN AND CHARACTERIZATION OF SYNTHETIC BIODEGRADABLE FILMS FOR MUSCULOSKELETAL TISSUE ENGINEERING published pages: , ISSN: 2049-4416, DOI:	The Bone & Joint Journal/Orthopaedic Proceedings	2020-04-15
2019	Mari Carmen Echave, Rui M. A. Domingues, Manuel GÃ³mez-Florit, JosÃ© Luis Pedraz, Rui L. Reis, Gorka Orive, Manuela E. Gomes Biphasic Hydrogels Integrating Mineralized and Anisotropic Features for Interfacial Tissue Engineering published pages: 47771-47784, ISSN: 1944-8244, DOI: 10.1021/acsami.9b17826	ACS Applied Materials & Interfaces 11/51	2020-03-05
2019	Ana I. GonÃ§alves, Dominika Berdecka, MÃ¡rcia T. Rodrigues, Aysegul Dede Eren, Jan Boer, Rui L. Reis, Manuela E. Gomes Evaluation of tenogenic differentiation potential of selected subpopulations of human adiposeâ€derived stem cells published pages: 2204-2217, ISSN: 1932-6254, DOI: 10.1002/term.2967	Journal of Tissue Engineering and Regenerative Medicine 13/12	2020-03-05
2019	Raquel Costa-Almeida, Isabel Calejo, Manuela E. Gomes Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies published pages: 3002, ISSN: 1422-0067, DOI: 10.3390/ijms20123002	International Journal of Molecular Sciences 20/12	2020-03-05
2020	Ana M. Matos, Ana I. GonÃ§alves, Alicia J. El Haj, Manuela E. Gomes Magnetic biomaterials and nano-instructive tools as mediators of tendon mechanotransduction published pages: 140-148, ISSN: 2516-0230, DOI: 10.1039/c9na00615j	Nanoscale Advances 2/1	2020-03-05
2018	A.I. GonÃ§alves, P.M. Gershovich, M.T. Rodrigues, R.L. Reis, M.E. Gomes Human adipose tissue-derived tenomodulin positive subpopulation of stem cells: A promising source of tendon progenitor cells published pages: 762-774, ISSN: 1932-6254, DOI: 10.1002/term.2495	Journal of Tissue Engineering and Regenerative Medicine 12/3	2019-10-08
2017	Mariana Laranjeira, Rui M. A. Domingues, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes 3D Mimicry of Native-Tissue-Fiber Architecture Guides Tendon-Derived Cells and Adipose Stem Cells into Artificial Tendon Constructs published pages: 1700689, ISSN: 1613-6810, DOI: 10.1002/smll.201700689	Small 13/31	2019-10-08
2017	Ana I. GonÃ§alves, MÃ¡rcia T. Rodrigues, Manuela E. Gomes Tissue-engineered magnetic cell sheet patches for advanced strategies in tendon regeneration published pages: 110-122, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.09.014	Acta Biomaterialia 63	2019-10-08
2016	Ana I. GonÃ§alves, MÃ¡rcia T. Rodrigues, Pedro P. Carvalho, Manuel BaÃ±obre-LÃ³pez, Elvira Paz, Paulo Freitas, Manuela E. Gomes Exploring the Potential of Starch/Polycaprolactone Aligned Magnetic Responsive Scaffolds for Tendon Regeneration published pages: 213-222, ISSN: 2192-2640, DOI: 10.1002/adhm.201500623	Advanced Healthcare Materials 5/2	2019-10-08
2018	Raquel Costa-Almeida, Rui M.A. Domingues, Afsoon Fallahi, Huseyin Avci, Iman K. Yazdi, Mohsen Akbari, Rui L. Reis, Ali Tamayol, Manuela E. Gomes, Ali Khademhosseini Cell-laden composite suture threads for repairing damaged tendons published pages: 1039-1048, ISSN: 1932-6254, DOI: 10.1002/term.2605	Journal of Tissue Engineering and Regenerative Medicine 12/4	2019-10-08
2018	Elsa D. Silva, Pedro S. Babo, Raquel Costa-Almeida, Rui M.A. Domingues, BÃ¡rbara B. Mendes, Elvira Paz, Paulo Freitas, MÃ¡rcia T. Rodrigues, Pedro L. Granja, Manuela E. Gomes Multifunctional magnetic-responsive hydrogels to engineer tendon-to-bone interface published pages: 2375-2385, ISSN: 1549-9634, DOI: 10.1016/j.nano.2017.06.002	Nanomedicine: Nanotechnology, Biology and Medicine 14/7	2019-10-08
2018	A.I. GonÃ§alves, M. Rotherham, H. Markides, M.T. Rodrigues, R.L. Reis, M.E. Gomes, A.J. El Haj Triggering the activation of Activin A type II receptor in human adipose stem cells towards tenogenic commitment using mechanomagnetic stimulation published pages: 1149-1159, ISSN: 1549-9634, DOI: 10.1016/j.nano.2018.02.008	Nanomedicine: Nanotechnology, Biology and Medicine 14/4	2019-10-08
2016	LÃvia Santos, Marta Silva, Ana I. GonÃ§alves, Tamagno Pesqueira, MÃ¡rcia T. Rodrigues, Manuela E. Gomes In vitro and in vivo assessment of magnetically actuated biomaterials and prospects in tendon healing published pages: 1107-1122, ISSN: 1743-5889, DOI: 10.2217/nnm-2015-0014	Nanomedicine 11/9	2019-10-08
2018	Raquel Costa-Almeida, Albina R. Franco, Tamagno Pesqueira, Mariana B. Oliveira, Pedro S. Babo, Isabel B. Leonor, JoÃ£o F. Mano, Rui L. Reis, Manuela E. Gomes The effects of platelet lysate patches on the activity of tendon-derived cells published pages: 29-40, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.01.006	Acta Biomaterialia 68	2019-10-08
2016	Rui M. A. Domingues, Silvia Chiera, Pavel Gershovich, Antonella Motta, Rui L. Reis, Manuela E. Gomes Enhancing the Biomechanical Performance of Anisotropic Nanofibrous Scaffolds in Tendon Tissue Engineering: Reinforcement with Cellulose Nanocrystals published pages: 1364-1375, ISSN: 2192-2640, DOI: 10.1002/adhm.201501048	Advanced Healthcare Materials 5/11	2019-10-08

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