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CONNECT SIGNED

Connecting neural networks: Nervous-system-on-Chip Technology

Total Cost €

EC-Contrib. €

Partnership

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CONNECT project word cloud

Explore the words cloud of the CONNECT project. It provides you a very rough idea of what is the project "CONNECT" about.

novel paradigm heavy firmly successful pns micro proof organ individual puts function mimic smart cell grasp model microfluidic strategies components society disciplines paving engineering models vitro time cns complete opportunity imaging parkinson disease first engineered scientific linkage elementary disorders nanofabrication neurodegenerative insights connectivity thereby single risk structure human clinical healthcare offers global microfluidics base community develops compartment connect functioning burden acts provides central ooc map forming chip completion cells platform convergence functions tissue culture form gain multitude recapitulate feasibility complexity limitations organs chips stem nervous therapeutic underlying therapeutics peripheral diseases

Project "CONNECT" data sheet

The following table provides information about the project.

Coordinator	TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	6˙807˙867 €
EC max contribution	6˙807˙867 € (100%)
Programme	1. H2020-EU.1.2.2. (FET Proactive)
Code Call	H2020-FETPROACT-2018-01
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITEIT EINDHOVEN TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (EINDHOVEN)	coordinator	1˙675˙000.00
2	UNIVERSITE DU LUXEMBOURG UNIVERSITE DU LUXEMBOURG Organization address address: 2 AVENUE DE L'UNIVERSITE city: ESCH-SUR-ALZETTE postcode: 4365 website: http://wwwen.uni.lu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LU (ESCH-SUR-ALZETTE)	participant	1˙247˙005.00
3	THE UNIVERSITY OF SHEFFIELD THE UNIVERSITY OF SHEFFIELD Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN website: www.shef.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SHEFFIELD)	participant	1˙010˙307.00
4	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	953˙125.00
5	AALTO KORKEAKOULUSAATIO SR AALTO KORKEAKOULUSAATIO SR Organization address address: OTAKAARI 1 city: ESPOO postcode: 2150 website: http://www.aalto.fi/en/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (ESPOO)	participant	903˙680.00
6	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	842˙500.00
7	FFUND BV FFUND BV Organization address address: BARBARA STROZZILAAN 101 city: AMSTERDAM postcode: 1083 HN website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	176˙250.00

Map

Project objective

Novel micro-engineered in vitro models have been developed to mimic key functions of human organs. These so-called organ-on-chips (OoC) recapitulate the structure and function of human organs, and are particularly important for scientific research that is underlying our knowledge base of diseases and for the pre-clinical development of novel therapeutics. However, the application of these models has its limitations as they do not mimic the complexity and functioning of complete organ systems. Connectivity between cells and the linkage between different components of organ systems is essential in studying complex conditions such as neurodegenerative diseases. These diseases form a major challenge for the scientific community and are associated with a heavy burden on society and the global healthcare systems. To effectively grasp the complexity of neurodegenerative disorders, the CONNECT consortium develops the next level in vitro model systems for the nervous system and puts it firmly on the map. The project acts at the convergence of a multitude of disciplines including nanofabrication, microfluidics, stem cell technology, tissue engineering and advanced imaging. The successful completion of this high risk-high gain project will enable for the first time to study a complete organ system and deliver a viable paradigm for future technology to study connectivity in the nervous system. The proposed work in this project offers a unique opportunity to culture individual nervous system components and connect them in a single “smart” microfluidic chip (CONNECT platform), forming an elementary three compartment model from the central nervous system (CNS) to the peripheral nervous system (PNS). As Proof-of-Principle, CONNECT will demonstrate the feasibility of this system model in Parkinson’s Disease. This provides CONNECT with novel insights, thereby paving the way for future development of therapeutic strategies.

Publications

List of publications.
year	authors and title	journal	last update
2019	Bastiaens, Xie, Luttge Nanogroove-Enhanced Hydrogel Scaffolds for 3D Neuronal Cell Culture: An Easy Access Brain-on-Chip Model published pages: 638, ISSN: 2072-666X, DOI: 10.3390/mi10100638	Micromachines 10/10	2020-02-05
2019	Alex Bastiaens, Jean-Philippe Frimat, Teun van Nunen, Regina Luttge Exploiting nanogroove-induced cell culture anisotropy to advance in vitro brain models published pages: 61802, ISSN: 2166-2754, DOI: 10.1116/1.5119687	Journal of Vacuum Science & Technology B 37/6	2020-02-05

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The information about "CONNECT" are provided by the European Opendata Portal: CORDIS opendata.