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SynBio4Flav SIGNED

Synthetic microbial consortia-based platform for flavonoids production using synthetic biology

Total Cost €

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EC-Contrib. €

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Partnership

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SynBio4Flav project word cloud

Explore the words cloud of the SynBio4Flav project. It provides you a very rough idea of what is the project "SynBio4Flav" about.

output smcs compounds containing 3d flavonoids trl5 flavonoid usability constrained biosynthesis optimal guided biochemical hierarchy abstraction complexity exploring re push dietary synbio4flav analogues despite demand regulated sysbio4flav optimized pipeline recreate scarce pursues synthesis plant complexes catalysis microbial functional genetically single assembly homogeneous durable routes distributed troubleshooting group remarkably corresponding market assembling biosynthetic phytonutrients food synthetic acting portions supplements tools chemicals beverages biotech elusive communities standardization full scenario biology engineered breaking libraries species biocatalyst optimizing nature instead space hundreds thousands smc glycosylated intense synthetized sources abundant biological programmed boundaries cell surrogate natural standardized pharmaceuticals compartments combinatorial cosmetics trafficking platform chemical

Project "SynBio4Flav" data sheet

The following table provides information about the project.

Coordinator	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	7˙371˙051 €
EC max contribution	7˙371˙051 € (100%)
Programme	1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
Code Call	H2020-NMBP-BIO-2018-two-stage
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2023-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	1˙704˙071.00
2	CHALMERS TEKNISKA HOEGSKOLA AB CHALMERS TEKNISKA HOEGSKOLA AB Organization address address: - city: GOETEBORG postcode: 41296 website: www.chalmers.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOETEBORG)	participant	1˙206˙128.00
3	UNIVERSITAET GREIFSWALD UNIVERSITAET GREIFSWALD Organization address address: DOMSTRASSE 11 city: GREIFSWALD postcode: 17489 website: www.uni-greifswald.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (GREIFSWALD)	participant	706˙250.00
4	UNIVERSIDAD DE OVIEDO UNIVERSIDAD DE OVIEDO Organization address address: CALLE SAN FRANCISCO 3 city: OVIEDO postcode: 33003 website: www.uniovi.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (OVIEDO)	participant	628˙985.00
5	BIOPOLIS SL BIOPOLIS SL Organization address address: CALLE CATEDRATICO AGUSTIN ESCARDINO 9 city: PATERNA VALENCIA postcode: 46980 website: www.biopolis.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (PATERNA VALENCIA)	participant	614˙752.00
6	EXPLORA SRL EXPLORA SRL Organization address address: Via Giacomo Peroni 386 city: ROMA postcode: 131 website: www.explora-biotech.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	566˙666.00
7	DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM REHBRUECKE DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM REHBRUECKE Organization address address: Arthur-Scheunert-Allee 114-116 city: NUTHETAL postcode: 14558 website: www.dife.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (NUTHETAL)	participant	552˙987.00
8	UNIWERSYTET PRZYRODNICZY WE WROCLAWIU UNIWERSYTET PRZYRODNICZY WE WROCLAWIU Organization address address: UL. CYPRIANA KAMILA NORWIDA 25 city: WROCLAW postcode: 50-375 website: www.up.wroc.pl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (WROCLAW)	participant	528˙110.00
9	LIQUIFER SYSTEMS GROUP GMBH LIQUIFER SYSTEMS GROUP GMBH Organization address address: OBERE DONAUSTRASSE 97-99 1 62 city: Vienna postcode: 1020 website: www.liquifer.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (Vienna)	participant	324˙378.00
10	EXTRASYNTHESE SAS EXTRASYNTHESE SAS Organization address address: IMPASSE JACQUARD ZI LYON NORD city: GENAY postcode: 69730 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (GENAY)	participant	270˙208.00
11	SYMRISE AG SYMRISE AG Organization address address: MUHLENFELDSTRASSE 1 city: HOLZMINDEN postcode: 37603 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HOLZMINDEN)	participant	268˙512.00

Map

Project objective

This Project pursues the implementation a standardized pipeline for surrogate production of plant flavonoids in synthetic microbial consortia (SMCs) by means of standardization and systems-guided assembly of highly complex biological devices. Flavonoids are the more abundant and consumed group of phytonutrients, used in numerous applications including functional food & beverages, dietary supplements, cosmetics, and pharmaceuticals. Despite its growing demand, flavonoids production remains elusive to chemical synthesis and biotech-based approaches, thus current flavonoid market is constrained to the scarce plant-based sources. These compounds are synthetized in nature through complex pathways involving an intense chemicals trafficking through plant compartments. By facilitating component troubleshooting and re-usability—instead of optimizing a single whole-cell biocatalyst— SynBio4Flav will recreate such non-homogeneous scenario by breaking-down specific portions of the complexes and highly regulated biochemical routes between different microbial species, each of them genetically programmed to deliver an optimal output of the corresponding biosynthetic step(s) i.e. through a distributed catalysis engineered in a defined SMC. Enabling such novel approach, SynBio4Flav will push the existing boundaries of the synthetic biology by acting along the whole Synthetic Biology hierarchy abstraction, and remarkably, in those with high complexity level e.g. cell systems and microbial communities. By creating libraries of optimized cell systems programmed to deliver an optimal output, and novel synthetic biology tools for cell systems assembling into 3D SMCs, SysBio4Flav will reach a TRL5 in production of natural and new-to-nature glycosylated flavonoids. The durable output of SynBio4Flav will be a standardized platform containing hundreds of optimal cell systems for exploring the full combinatorial space of flavonoids biosynthesis, including thousands of new-to-nature analogues.

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The information about "SYNBIO4FLAV" are provided by the European Opendata Portal: CORDIS opendata.

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