Opendata, web and dolomites

ArtHep SIGNED

Hepatocytes-Like Microreactors for Liver Tissue Engineering

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ArtHep project word cloud

Explore the words cloud of the ArtHep project. It provides you a very rough idea of what is the project "ArtHep" about.

reduce    opportunity    slowing    matching    entities    alcoholic    mimics    purposes    consisting    moving    cues    progress    functions    epidemics    perform    scientific    am    grow    active    live    efforts    mechanical    hepatic    mimic    rats    synthetic    surface    enzyme    foundation    anticipated    dimensions    consolidating    angled    fatty    destined    core    unexplored    assembly    engineering    ground    excellence    obesity    connect    abundancy    conversions    matured    damage    obtain    cell    liver    cells    biocatalytic    regeneration    donor    damaged    connection    coating    game    science    organs    career    structure    encapsulation    lobules    disease    criteria    entirely    pressure    convinced    mimicking    transplanted    breaking    ex    bioprinted    vivo    diabetes    medical    match    global    subunits    demand    arthep    microreactors    biomimicry    camouflaging    changing    causing    transplant    counteract    insufficient    biological    transplants    micro    carriers    shortage    environment    tissue   

Project "ArtHep" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙992˙289 €
 EC max contribution 1˙992˙289 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2024-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 1˙992˙289.00

Map

 Project objective

The global epidemics of obesity and diabetes type 2 lead to higher abundancy of medical conditions like non-alcoholic fatty liver disease causing an increase in liver failure and demand for liver transplants. The shortage of donor organs and the insufficient success in tissue engineering to ex vivo grow complex organs like the liver is a global medical challenge.

ArtHep targets the assembly of hepatic-like tissue, consisting of biological and synthetic entities, mimicking the core structure elements and key functions of the liver. ArtHep comprises an entirely new concept in liver regeneration with multi-angled core impact: i) cell mimics are expected to reduce the pressure to obtain donor cells, ii) the integrated biocatalytic subunits are destined to take over tasks of the damaged liver slowing down the progress of liver damage, and iii) the matching micro-environment in the bioprinted tissue is anticipated to facilitate the connection between the transplant and the liver.

Success criteria of ArtHep include engineering enzyme-mimics, which can perform core biocatalytic conversions similar to the liver, the assembly of biocatalytic active subunits and their encapsulation in cell-like carriers (microreactors), which have mechanical properties that match the liver tissue and that have a camouflaging coating to mimic the surface cues of liver tissue-relevant cells. Finally, matured bioprinted liver-lobules consisting of microreactors and live cells need to connect to liver tissue when transplanted into rats.

I am convinced that the ground-breaking research in ArtHep will contribute to the excellence of science in Europe while providing the game-changing foundation to counteract the ever increasing donor liver shortage. Further, consolidating my scientific efforts and moving them forward into unexplored dimensions in biomimicry for medical purposes, is a unique opportunity to advance my career.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ARTHEP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ARTHEP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

Aware (2019)

Aiding Antibiotic Development with Deep Analysis of Resistance Evolution

Read More  

MUSMICRO (2020)

Causes and consequences of variation in the mammalian microbiota

Read More