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ArtHep SIGNED

Hepatocytes-Like Microreactors for Liver Tissue Engineering

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ArtHep project word cloud

Explore the words cloud of the ArtHep project. It provides you a very rough idea of what is the project "ArtHep" about.

angled    pressure    lobules    assembly    breaking    biomimicry    mimicking    match    epidemics    biological    opportunity    enzyme    structure    counteract    slowing    mimic    synthetic    camouflaging    connect    convinced    obtain    mimics    cell    criteria    destined    micro    matured    engineering    functions    damage    global    transplanted    game    regeneration    microreactors    environment    active    dimensions    insufficient    carriers    entities    core    arthep    transplant    perform    cues    transplants    ex    vivo    changing    encapsulation    coating    causing    diabetes    scientific    connection    cells    damaged    biocatalytic    shortage    mechanical    medical    live    moving    purposes    entirely    rats    abundancy    career    ground    matching    bioprinted    consisting    donor    liver    reduce    unexplored    surface    excellence    hepatic    fatty    foundation    obesity    science    anticipated    efforts    conversions    subunits    tissue    demand    organs    progress    am    grow    consolidating    disease    alcoholic   

Project "ArtHep" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙992˙289 €
 EC max contribution 1˙992˙289 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2024-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 1˙992˙289.00

Map

 Project objective

The global epidemics of obesity and diabetes type 2 lead to higher abundancy of medical conditions like non-alcoholic fatty liver disease causing an increase in liver failure and demand for liver transplants. The shortage of donor organs and the insufficient success in tissue engineering to ex vivo grow complex organs like the liver is a global medical challenge.

ArtHep targets the assembly of hepatic-like tissue, consisting of biological and synthetic entities, mimicking the core structure elements and key functions of the liver. ArtHep comprises an entirely new concept in liver regeneration with multi-angled core impact: i) cell mimics are expected to reduce the pressure to obtain donor cells, ii) the integrated biocatalytic subunits are destined to take over tasks of the damaged liver slowing down the progress of liver damage, and iii) the matching micro-environment in the bioprinted tissue is anticipated to facilitate the connection between the transplant and the liver.

Success criteria of ArtHep include engineering enzyme-mimics, which can perform core biocatalytic conversions similar to the liver, the assembly of biocatalytic active subunits and their encapsulation in cell-like carriers (microreactors), which have mechanical properties that match the liver tissue and that have a camouflaging coating to mimic the surface cues of liver tissue-relevant cells. Finally, matured bioprinted liver-lobules consisting of microreactors and live cells need to connect to liver tissue when transplanted into rats.

I am convinced that the ground-breaking research in ArtHep will contribute to the excellence of science in Europe while providing the game-changing foundation to counteract the ever increasing donor liver shortage. Further, consolidating my scientific efforts and moving them forward into unexplored dimensions in biomimicry for medical purposes, is a unique opportunity to advance my career.

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The information about "ARTHEP" are provided by the European Opendata Portal: CORDIS opendata.

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